| Identification |
|---|
| HMDB Protein ID
| CDBP03730 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ran-binding protein 3 |
| Description
| Not Available |
| Synonyms
|
- RanBP3
|
| Gene Name
| RANBP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular transport |
| Specific Function
| Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner |
| GO Classification
|
| Process |
| establishment of localization |
| transport |
| intracellular transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.3 |
| SNPs
| RANBP3 |
| Gene Sequence
|
>1704 bp
ATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAG
AAGGATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAG
CCTCGGGGGGAGGCTGAGGCCCCCCACCATGGCACGGGTCACCCCGAGTCAGCTGGCGAG
CATGCCCTAGAACCTCCTGCCCCTGCTGGCGCCTCAGCCAGCACTCCTCCGCCTCCCGCT
CCTGAAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGAGGTCAGCTGGCGGCTCC
AGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAG
CGAGAAAGAACATCCTCTTTAACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGT
GGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGTCTGCCA
AGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCG
CAGCCAAAGGCGCTGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCA
GCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGAAGTCCT
TCCGAAGCTGCCGATGAGGTGTGTGCACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCC
AGCAATGCCTCTGAAGAGGAAGCCTGTGAGAAAAAAGACCCCGCCACACAGCAAGCCTTT
GTATTTGGGCAGAACTTGAGGGACAGAGTTAAGCTGATAAATGAGAGCGTGGACGAAGCC
GACATGGAGAATGCTGGACACCCCAGCGCAGACACGCCAACCGCAACGAACTATTTCCTC
CAGTATATCAGTTCCAGTTTAGAGAACTCAACCAATAGTGCCGACGCCTCCAGCAACAAA
TTTGTATTTGGCCAGAACATGAGCGAGCGAGTTTTGAGCCCCCCAAAATTAAACGAGGTC
AGTTCAGATGCCAACAGGGAAAATGCAGCTGCCGAGTCAGGGTCTGAGTCCTCGTCCCAG
GAGGCCACCCCTGAGAAAGAGTCCCTGGCTGAGTCGGCAGCCGCCTACACCAAGGCAACA
GCGCGGAAGTGTTTGTTGGAAAAAGTGGAAGTCATCACCGGGGAGGAGGCGGAGAGCAAT
GTGTTACAGATGCAGTGCAAGCTGTTTGTCTTTGACAAGACCTCACAGTCCTGGGTGGAG
AGAGGCCGGGGGCTGCTCAGACTCAATGACATGGCGTCCACCGATGACGGCACACTACAG
TCCCGACTAGTGATGCGGACCCAGGGGAGCCTGCGACTGATCCTCAACACCAAGCTGTGG
GCCCAGATGCAGATCGACAAGGCCAGCGAGAAGAGCATTCGCATCACAGCCATGGACACC
GAGGACCAGGGCGTGAAGGTCTTCCTGATCTCGGCCAGCTCCAAGGACACAGGTCAGTTG
TATGCAGCCCTGCACCACCGCATCCTGGCCCTGCGCAGCCGCGTGGAGCAGGAGCAGGAG
GCCAAGATGCCCGCGCCTGAGCCTGGGGCAGCCCCATCCAACGAGGAGGACGACAGCGAC
GATGACGATGTCCTGGCTCCTTCAGGGGCCACCGCAGCTGGTGCTGGTGACGAAGGGGAC
GGGCAGACGACCGGGAGCACATAG
|
| Protein Properties |
|---|
| Number of Residues
| 567 |
| Molecular Weight
| 60209.3 |
| Theoretical pI
| 4.42 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ran-binding protein 3
MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGE
HALEPPAPAGASASTPPPPAPEAQLPPFPRELAGRSAGGSSPEGGEDSDREDGNYCPPVK
RERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAP
QPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNES
SNASEEEACEKKDPATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFL
QYISSSLENSTNSADASSNKFVFGQNMSERVLSPPKLNEVSSDANRENAAAESGSESSSQ
EATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQMQCKLFVFDKTSQSWVE
RGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDT
EDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEAKMPAPEPGAAPSNEEDDSD
DDDVLAPSGATAAGAGDEGDGQTTGST
|
| External Links |
|---|
| GenBank ID Protein
| 6466466 |
| UniProtKB/Swiss-Prot ID
| Q9H6Z4 |
| UniProtKB/Swiss-Prot Entry Name
| RANB3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_007322.2 |
| GeneCard ID
| RANBP3 |
| GenAtlas ID
| RANBP3 |
| HGNC ID
| HGNC:9850 |
| References |
|---|
| General References
| Not Available |