| Identification |
|---|
| HMDB Protein ID
| CDBP03728 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras-related C3 botulinum toxin substrate 3 |
| Description
| Not Available |
| Synonyms
|
- p21-Rac3
|
| Gene Name
| RAC3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cytoplasm
- Endomembrane system
- Cell projection
- lamellipodium
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q25.3 |
| SNPs
| RAC3 |
| Gene Sequence
|
>579 bp
ATGCAGGCCATCAAGTGCGTGGTGGTCGGCGACGGCGCCGTGGGGAAGACATGCTTGCTG
ATCAGCTACACGACCAACGCCTTCCCCGGAGAGTACATCCCCACCGTTTTTGACAACTAC
TCTGCCAACGTGATGGTGGACGGGAAACCAGTCAACTTGGGGCTGTGGGACACAGCGGGT
CAGGAGGACTACGATCGGCTGCGGCCACTCTCCTACCCCCAAACTGACGTCTTTCTGATC
TGCTTCTCTCTGGTGAGCCCGGCCTCCTTCGAGAATGTTCGTGCCAAGTGGTACCCGGAG
GTGCGGCACCACTGCCCCCACACGCCCATCCTCCTGGTGGGCACCAAGCTGGACCTCCGC
GACGACAAGGACACCATTGAGCGGCTGCGGGACAAGAAGCTGGCACCCATCACCTACCCA
CAGGGCCTGGCCATGGCCCGGGAGATTGGCTCTGTGAAATACCTGGAGTGCTCAGCCCTG
ACCCAGCGGGGCCTGAAGACAGTGTTTGACGAGGCGATCCGCGCGGTGCTCTGCCCGCCC
CCAGTGAAGAAGCCGGGGAAGAAGTGCACCGTCTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 192 |
| Molecular Weight
| 21378.7 |
| Theoretical pI
| 8.27 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras-related C3 botulinum toxin substrate 3
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG
QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR
DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP
PVKKPGKKCTVF
|
| External Links |
|---|
| GenBank ID Protein
| 2326206 |
| UniProtKB/Swiss-Prot ID
| P60763 |
| UniProtKB/Swiss-Prot Entry Name
| RAC3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF008591 |
| GeneCard ID
| RAC3 |
| GenAtlas ID
| RAC3 |
| HGNC ID
| HGNC:9803 |
| References |
|---|
| General References
| Not Available |