| Identification |
|---|
| HMDB Protein ID
| CDBP03727 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rab5 GDP/GTP exchange factor |
| Description
| Not Available |
| Synonyms
|
- RAP1
- Rabaptin-5-associated exchange factor for Rab5
- Rabex-5
|
| Gene Name
| RABGEF1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase |
| GO Classification
|
| Function |
| dna binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| nucleic acid binding |
|
| Cellular Location
|
- Cytoplasm
- Early endosome
- Recycling endosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q11.21 |
| SNPs
| RABGEF1 |
| Gene Sequence
|
>2127 bp
ATGGTGGTAGTCACGGGGCGGGAGCCAGACAGCCGTCGTCAGGACGGTGCCATGTCCAGC
TCTGACGCCGAAGACGACTTTCTGGAGCCGGCCACGCCGACGGCCACGCAGGCGGGGCAC
GCGCTGCCCCTGCTGCCACAGGAGAGATGTGCTGAATTTCCTGCGCTCAGGGGACCTCCC
ACCCAGGGAGCGTGTTCGAGCTGTGTACAAAGAGGCCCAGTACTATGCCATCGGGCCCCT
CCTGGAGCAGCTGGAGAACATGCAGCCACTGAAGGGCGAGAAGGTGCGCCAAGCGTTTCT
GGGACTCATGCCCTATTACAAAGACCACTTGGAGCGGATTGTGGAGATCGCCCGGCTGCG
TGCGGTCCAGCGGAAGGCCCGCTTTGCCAAGCTCAAGTGGTTAGCAGGAAGAAGATGAGC
CTTAAGTCTGAACGCCGAGGAATTCATGTGGATCAATCGGATCTCCTGTGCAAGAAAGGA
TGTGGTTACTACGGCAACCCTGCCTGGCAGGGTTTCTGCTCCAAGTGCTGGAGGGAAGAG
TACCACAAAGCCAGGCAGAAGCAGATTCAGGAGGACTGGGAGCTGGCGGAGCGGGTCTTG
CTCTGTTGCCCTGGCTGGAGTGCAATGGTGCAATTTCAACTTACTGCAACCTCTGCTTCC
TGGGCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAGTGGCTGGGACTACAGAAACTCCAG
CGGGAGGAAGAAGAGGCCTTTGCCAGCAGTCAGAGCAGCCAAGGGGCCCAATCCCTCACA
TTCTCCAAGTTTGAAGAAAAGAAAACCAACGAGAAGACCCGCAAGGTTACCACAGTGAAG
AAATTCTTCAGTGCATCTTCCAGGGTCGGATCAAAGAAGGAAATTCAGGAAGCAAAAGCT
CCCAGTCCTTCCATAAACCGGCAAACCAGCATTGAAACGGATAGAGTGTCTAAGGAGTTC
ATAGAATTTCTCAAGACCTTCCACAAGACAGGCCAAGAAATCTATAAACAGACCAAGCTG
TTTTTGGAAGGAATGCATTACAAAAGGGATCTAAGCATTGAAGAACAGTCAGAGTGTGCT
CAGGATTTCTACCACAATGTGGCCGAAAGGATGCAAACTCGTGGGAAAGAGAGGAGATTT
CACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGCGATCCACCTGCCTCAGCC
TCCCAAAGTGCTGGGAATACAGGAGTAGAGCCACCGCACCCAGCTGTGCCTCCAGAAAGA
GTCGAGAAGATAATGGATCAGATTGAAAAGTACATCATGACTCGTCTCTATAAATATGTA
TTCTGTCCAGAAACTACTGATGATGAGAAGAAAGATCTTGCCATTCAAAAGAGAATCAGA
GCCCTGCGCTGGGTTACGCCTCAGATGCTGTGTGTCCCTGTTAATGACGACATCCCAGAA
GTATCTGATATGGTGGTGAAGGCGATCACAGATATCATTGAAATGGATTCCAAGCGTGTG
CCTCGAGACAAGCTGGCCTGCATCACCAAGTGCAGCAAGCACATCTTCAATGCCATCAAG
ATCACCAAGAATGAGCCGGCGTCAGCGGATGACTTCCTCCCCACCCTCATCTACATTGTT
TTGAAGGGCAACCCCCCACGCCTTCAGTCTAATATCCAGTATATCACGCGCTTCTGCAAT
CCAAGCCGACTGATGACTGGAGAGGATGGCTACTATTTCACCAATCTGTGCTGTGCTGTG
GCTTTCATTGAGAAGCTAGACGCCCAGTCTTTGAATCTAAGTCAGGAGGATTTTGATCGC
TACATGTCTGGCCAGACCTCTCCCAGGAAGCAAGAAGCTGAGAGTTGGTCTCCTGATGCT
TGCTTAGGCGTCAAGCAAATGTATAAGAACTTGGATCTCTTGTCTCAGTTGAATGAACGA
CAAGAAAGGATCATGAATGAAGCCAAGAAACTGGAAAAAGACCTCATAGATTGGACAGAT
GGAATTGCAAGAGAAGTTCAAGACATCGTTGAGAAATACCCACTGGAAATTAAGCCTCCG
AATCAACCGTTAGCAGCTATTGACTCTGAAAACGTTGAAAATGATAAACTTCCTCCACCA
CTGCAACCTCAAGTTTATGCAGGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 708 |
| Molecular Weight
| 79370.5 |
| Theoretical pI
| 6.81 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rab5 GDP/GTP exchange factor
MVVVTGREPDSRRQDGAMSSSDAEDDFLEPATPTATQAGHALPLLPQERCAEFPALRGPP
TQGACSSCVQRGPVLCHRAPPGAAGEHAATEGREGAPSVSGTHALLQRPLGADCGDRPAA
CGPAEGPLCQAQVVSRKKMSLKSERRGIHVDQSDLLCKKGCGYYGNPAWQGFCSKCWREE
YHKARQKQIQEDWELAERVLLCCPGWSAMVQFQLTATSASWAQVILLLQPPKWLGLQKLQ
REEEEAFASSQSSQGAQSLTFSKFEEKKTNEKTRKVTTVKKFFSASSRVGSKKEIQEAKA
PSPSINRQTSIETDRVSKEFIEFLKTFHKTGQEIYKQTKLFLEGMHYKRDLSIEEQSECA
QDFYHNVAERMQTRGKERRFHHVGQAGLELLTSGDPPASASQSAGNTGVEPPHPAVPPER
VEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLAIQKRIRALRWVTPQMLCVPVNEDIPE
VSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIV
LKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDR
YMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTD
GIAREVQDIVEKYPLEIKPPNQPLAAIDSENVENDKLPPPLQPQVYAG
|
| External Links |
|---|
| GenBank ID Protein
| 34534860 |
| UniProtKB/Swiss-Prot ID
| Q9UJ41 |
| UniProtKB/Swiss-Prot Entry Name
| RABX5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK127790 |
| GeneCard ID
| RABGEF1 |
| GenAtlas ID
| RABGEF1 |
| HGNC ID
| HGNC:17676 |
| References |
|---|
| General References
| Not Available |