| Identification |
|---|
| HMDB Protein ID
| CDBP03725 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rab GTPase-binding effector protein 2 |
| Description
| Not Available |
| Synonyms
|
- Rabaptin-5beta
|
| Gene Name
| RABEP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTPase activator activity |
| Specific Function
| Plays a role in membrane trafficking and in homotypic early endosome fusion |
| GO Classification
|
| Function |
| receptor binding |
| growth factor activity |
| enzyme activator activity |
| gtpase activator activity |
| binding |
| enzyme regulator activity |
| protein binding |
|
| Cellular Location
|
- Cytoplasm
- Early endosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p11.2 |
| SNPs
| RABEP2 |
| Gene Sequence
|
>1710 bp
ATGGCGGCAGCTGCGCCGGTGGCCGCGGACGACGATGAGCGGCGGCGGCGGCCGGGGGCT
GCACTGGAGGACTCCCGGTCCCAGGAAGGGGCAAATGGTGAGGCCGAGTCAGGTGAGCTC
AGCCGGCTTCGGGCTGAGCTGGCAGGCGCCCTGGCAGAAATGGAAACCATGAAGGCTGTG
GCAGAGGTGAGCGAGAGCACGAAGGCCGAGGCTGTGGCTGCGGTGCAGCGGCAGTGCCAA
GAGGAGGTGGCCTCGCTGCAGGCCATCCTGAAAGACTCCATCAGCAGCTATGAAGCCCAG
ATCACCGCCCTGAAGCAGGAGCGACAGCAGCAGCAGCAGGACTGTGAGGAGAAGGAGCGG
GAGCTGGGCCGCCTGAAGCAGCTGCTGTCCCGGGCCTACCCCCTGGACTCCCTGGAGAAG
CAGATGGAAAAGGCCCACGAGGACTCGGAGAAGCTGCGGGAGATCGTACTGCCCATGGAA
AAGGAGATCGAGGAGCTGAAGGCGAAGCTGCTGAGGGCCGAGGAGCTGATTCAGGAGATC
CAGAGACGTCCCCGGCATGCCCCTTCCCTGCACGGCTCCACGGAGTTGCTGCCCCTGTCC
CGGGATCCATCGCCCCCGCTGGAGCCTCTGGAGGAGCTGAGCGGAGATGGGGGTCCAGCC
GCTGAGGCCTTCGCTCACAACTGCGATGACAGCGCCTCCATCTCCTCCTTCTCCCTTGGC
GGTGGGGTCGGCAGCAGCTCCTCCCTGCCCCAAAGCCGCCAGGGCCTGAGCCCTGAACAG
GAAGAGACGGCCTCGCTGGTGTCTACGGGCACCCTGGTTCCCGAGGGCATCTACCTGCCC
CCTCCTGGCTACCAGCTCGTCCCAGACACTCAGTGGGAGCAGCTGCAGACAGAGGGCCGA
CAGCTGCAGAAGGACCTGGAGAGCGTCAGTCGCGAGCGGGACGAGCTCCAAGAGGGCCTG
AGACGGAGCAATGAGGACTGTGCCAAGCAGATGCAGGTGCTCCTGGCCCAGGTCCAGAAC
TCAGAGCAGCTGCTGCGGACCCTGCAAGGGACCGTGAGCCAGGCCCAGGAGCGGGTGCAG
CTGCAGATGGCGGAGCTGGTCACCACCCACAAGTGCCTGCACCATGAGGTAAAGCGGTTG
AATGAGGAAAACCAAGGGCTCCGGGCCGAGCAGCTGCCATCCTCAGCCCCCCAGGGCTCG
CAGCAGGAGCAGGGCGAGGAGGAATCACTGCCCAGCTCTGTGCCAGAGCTGCAGCAGCTG
CTGTGCTGCACGCGGCAAGAGGCGAGGGCCCGGCTGCAGGCCCAGGAGCACGGGGCCGAG
CGCCTGCGGATCGAGATCGTGACGCTGCGGGAGGCTCTGGAGGAGGAGACAGTGGCCAGG
GCCAGCCTGGAGGGGCAGCTGAGGGTGCAGCGGGAGGAGACAGAGGTGCTGGAGGCCTCC
CTGTGCAGCCTGAGGACAGAGATGGAGCGGGTGCAGCAGGAACAGAGCAAGGCCCAGCTC
CCAGACCTCCTCTCAGAACAGAGGGCCAAGGTGCTGCGGCTGCAGGCAGAGCTGGAGACC
AGTGAGCAGGTGCAGAGGGATTTCGTGCGACTGTCCCAGGCCCTGCAGGTGCGCCTAGAG
CGGATCCGCCAGGCTGAGACCCTGGAGCAAGTGCGCAGCATCATGGATGAGGCGCCACTC
ACGGACGTCAGGGACATCAAGGACACCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 569 |
| Molecular Weight
| 63542.2 |
| Theoretical pI
| 4.45 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rab GTPase-binding effector protein 2
MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV
AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKER
ELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI
QRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG
GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR
QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ
LQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQL
LCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEAS
LCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLE
RIRQAETLEQVRSIMDEAPLTDVRDIKDT
|
| External Links |
|---|
| GenBank ID Protein
| 117956403 |
| UniProtKB/Swiss-Prot ID
| Q9H5N1 |
| UniProtKB/Swiss-Prot Entry Name
| RABE2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_024816.2 |
| GeneCard ID
| RABEP2 |
| GenAtlas ID
| RABEP2 |
| HGNC ID
| HGNC:24817 |
| References |
|---|
| General References
| Not Available |