| Identification |
|---|
| HMDB Protein ID
| CDBP03724 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rab GTPase-binding effector protein 1 |
| Description
| Not Available |
| Synonyms
|
- Rabaptin-4
- Rabaptin-5
- Rabaptin-5alpha
- Renal carcinoma antigen NY-REN-17
|
| Gene Name
| RABEP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTPase activator activity |
| Specific Function
| Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A |
| GO Classification
|
| Function |
| binding |
| enzyme regulator activity |
| protein binding |
| receptor binding |
| growth factor activity |
| enzyme activator activity |
| gtpase activator activity |
|
| Cellular Location
|
- Cytoplasm
- Early endosome
- Recycling endosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17p13.2 |
| SNPs
| RABEP1 |
| Gene Sequence
|
>2589 bp
ATGGCGCAGCCGGGCCCGGCTTCCCAGCCTGACGTTTCTCTTCAGCAACGGGTAGCAGAA
TTGGAAAAAATTAATGCAGAATTTTTACGTGCACAACAGCAGCTTGAACAAGAATTTAAT
CAAAAGAGAGCAAAATTTAAGGAGTTATATTTGGCTAAAGAGGAGGATCTGAAGAGGCAA
AATGCAGTATTACAAGCTGCACAAGATGATTTGGGACACCTTCGAACCCAGCTGTGGGAA
GCTCAAGCAGAGATGGAGAATATTAAGGCGATTGCCACAGTCTCTGAGAACACCAAGCAA
GAAGCTATAGATGAAGTGAAAAGACAGTGGAGAGAAGAAGTTGCTTCACTTCAGGCTGTT
ATGAAAGAAACAGTTCGTGACTATGAGCACCAGTTCCACCTTAGGCTGGAGCAGGAGCGA
ACACAGTGGGCACAGTATAGAGAATCCGCAGAGAGGGAAATAGCTGATTTAAGAAGAAGG
CTGTCTGAAGGTCAAGAGGAGGAAAATTTAGAAAATGAAATGAAAAAGGCCCAAGAGGAT
GCTGAGAAACTTCGGTCCGTTGTGATGCCAATGGAAAAGGAAATTGCAGCTTTGAAGGAT
AAACTGACAGAGGCTGAAGACAAAATTAAAGAGCTGGAGGCCTCAAAGGTTAAAGAACTG
AATCATTATCTGGAAGCTGAGAAATCTTGTAGGACTGATCTAGAGATGTATGTAGCTGTT
TTGAATACTCAGAAATCTGTTCTACAGGAAGATGCTGAGAAACTGCGGAAAGAATTGCAT
GAAGTTTGCCATCTCTTGGAGCAAGAGCGACAACAACACAACCAGTTAAAACATACGTGG
CAGAAGGCCAATGACCAGTTTCTGGAATCTCAGCGTTTACTGATGAGAGACATGCAGCGA
ATGGAGATTGTGCTAACTTCAGAACAGCTCCGACAAGTTGAAGAACTGAAGAAGAAAGAT
CAGGAGGATGATGAACAACAAAGACTCAATAAGAGAAAGGATCACAAAAAAGCAGATGTT
GAGGAAGAAATAAAAATACCAGTAGTGTGTGCTTTAACTCAAGAAGAATCTTCAGCCCAG
TTATCAAATGAAGAGGAGCATTTAGACAGCACCCGTGGCTCAGTTCATTCCTTAGATGCA
GGCTTGCTGTTGCCATCTGGAGATCCTTTCAGTAAATCGGACAATGACATGTTTAAAGAT
GGACTCAGGAGAGCACAGTCTACAGACAGCTTGGGAACCTCGGGCTCATTGCAATCCAAA
GCTTTAGGCTATAACTACAAAGCAAAATCTGCTGGAAACCTGGACGAGTCAGATTTTGGA
CCACTGGTAGGAGCAGATTCAGTGTCTGAGAACTTTGATACTGCATCCCTTGGGTCACTC
CAGATGCCAAGTGGGTTTATGTTAACCAAAGATCAGGAAAGAGCAATCAAGGCGATGACA
CCAGAACAAGAAGAGACAGCGTCCCTCCTCTCCAGCGTTACCCAGGGCATGGAGAGTGCC
TATGTGTCCCCTAGTGGTTATCGTTTAGTTAGTGAAACAGAATGGAATCTCTTGCAGAAA
GAGGTACATAATGCTGGAAATAAACTTGGTAGACGTTGTGATATGTGTTCCAATTACGAA
AAACAGTTACAAGGAATTCAGATTCAGGAGGCTGAAACGAGAGACCAGGTGAAAAAACTA
CAGCTGATGCTAAGGCAAGCTAATGACCAGTTAGAGAAGACAATGAAAGATAAGCAGGAG
CTGGAAGACTTCATAAAGCAAAGCAGCGAAGATTCGAGTCACCAGATCTCTGCACTCGTC
CTAAGAGCCCAGGCCTCCGAGATCTTACTTGAAGAGTTACAGCAGGGGCTTTCCCAGGCA
AAGAGGGATGTTCAGGAACAGATGGCGGTGCTGATGCAGTCACGGGAACAGGTTTCAGAA
GAGCTGGTGAGGTTACAGAAAGATAATGACAGTCTCCAGGGAAAGCACAGCCTGCATGTG
TCATTACAGCAAGCAGAAGACTTCATCCTCCCAGACACTACAGAGGCACTGCGGGAGTTG
GTATTAAAATACCGTGAGGACATCATTAATGTGCGGACAGCAGCAGACCACGTAGAAGAA
AAGCTGAAGGCTGAGATACTTTTCCTAAAAGAGCAGATCCAAGCAGAACAGTGTTTAAAA
GAAAATCTTGAAGAAACTCTGCAACTAGAAATAGAAAACTGCAAGGAGGAAATAGCTTCT
ATTTCTAGCCTAAAAGCTGAATTAGAAAGAATAAAAGTGGAAAAAGGACAGTTGGAGTCC
ACATTAAGAGAGAAGTCTCAACAGCTTGAGAGTCTTCAGGAAATAAAGATCAGTTTGGAA
GAGCAGTTAAAGAAAGAGACTGCTGCTAAGGCTACCGTTGAACAACTAATGTTTGAAGAG
AAGAATAAAGCTCAGAGATTACAGACAGAATTAGATGTCAGTGAGCAAGTCCAGAGGGAT
TTTGTAAAGCTTTCACAGACCCTTCAGGTGCAGTTAGAGCGGATCCGGCAAGCTGACTCC
TTGGAGAGAATCCGGGCAATTCTGAATGATACTAAACTGACAGACATTAACCAGCTTCCT
GAGACATGA
|
| Protein Properties |
|---|
| Number of Residues
| 862 |
| Molecular Weight
| 99289.7 |
| Theoretical pI
| 4.66 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rab GTPase-binding effector protein 1
MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE
EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS
LERIRAILNDTKLTDINQLPET
|
| External Links |
|---|
| GenBank ID Protein
| 31377798 |
| UniProtKB/Swiss-Prot ID
| Q15276 |
| UniProtKB/Swiss-Prot Entry Name
| RABE1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_004703.4 |
| GeneCard ID
| RABEP1 |
| GenAtlas ID
| RABEP1 |
| HGNC ID
| HGNC:17677 |
| References |
|---|
| General References
| Not Available |