| Identification |
|---|
| HMDB Protein ID
| CDBP03715 |
| Secondary Accession Numbers
| Not Available |
| Name
| Partitioning defective 3 homolog |
| Description
| Not Available |
| Synonyms
|
- ASIP
- Atypical PKC isotype-specific-interacting protein
- CTCL tumor antigen se2-5
- PAR-3
- PAR3-alpha
- PARD-3
|
| Gene Name
| PARD3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Cytoplasm
- Endomembrane system
- cytoskeleton
- Cell junction
- Cell junction
- tight junction
- cell cortex
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10p11.21 |
| SNPs
| PARD3 |
| Gene Sequence
|
>4071 bp
ATGAAAGTGACCGTGTGCTTCGGACGGACCCGGGTGGTCGTGCCGTGCGGGGACGGCCAC
ATGAAAGTTTTCAGCCTCATCCAGCAGGCGGTGACCCGCTACCGGAAGGCCATCGCCAAG
GATCCAAACTACTGGATACAGGTGCATCGCTTGGAACATGGAGATGGAGGAATACTAGAC
CTTGATGACATTCTTTGTGATGTAGCAGACGATAAAGACAGACTGGTAGCAGTGTTTGAT
GAGCAGGATCCACATCACGGAGGTGATGGCACCAGTGCCAGTTCCACGGGTACCCAGAGC
CCAGAGATATTTGGTAGTGAGCTTGGCACCAACAATGTCTCAGCCTTTCAGCCTTACCAA
GCAACAAGTGAAATTGAGGTCACACCTTCAGTCCTTCGAGCAAATATGCCTCTTCATGTT
CGACGCAGTAGTGACCCAGCTCTAATTGGCCTCTCCACTTCTGTCAGTGATAGTAATTTT
TCCTCTGAAGAGCCTTCAAGGAAAAATCCCACACGCTGGTCAACAACAGCTGGCTTCCTC
AAGCAGAACACTGCTGGGAGTCCTAAAACCTGCGACAGGAAGAAAGATGAAAACTACAGA
AGCCTCCCGCGGGATACTAGTAACTGGTCTAACCAATTTCAGAGAGACAATGCTCGCTCG
TCTCTGAGTGCCAGTCACCCAATGGTGGGCAAGTGGCTGGAGAAACAAGAACAGGATGAG
GATGGGACAGAAGAGGATAACAGTCGTGTTGAACCTGTTGGACATGCTGACACGGGTTTG
GAGCATATACCCAACTTTTCTCTGGATGATATGGTAAAGCTCGTAGAAGTCCCCAACGAT
GGAGGGCCTCTGGGAATCCATGTAGTGCCTTTCAGTGCTCGAGGCGGCAGAACCCTGGGG
TTATTAGTAAAACGATTGGAGAAAGGTGGTAAAGCTGAACATGAAAATCTTTTTCGTGAG
AATGATTGCATTGTCAGGATTAATGATGGCGACCTTCGAAATAGAAGATTTGAACAAGCA
CAACATATGTTTCGCCAAGCCATGCGTACACCCATCATTTGGTTCCATGTGGTTCCTGCA
GCAAATAAAGAGCAGTATGAACAACTATCCCAAAGTGAGAAGAACAATTACTATTCAAGC
CGTTTTAGCCCTGACAGCCAGTATATTGACAACAGGAGTGTGAACAGTGCAGGGCTTCAC
ACGGTGCAGAGAGCACCCCGACTGAACCACCCGCCTGAGCAGATAGACTCTCACTCAAGA
CTACCTCATAGCGCACACCCCTCGGGAAAACCACCATCCGCTCCAGCCTCGGCACCTCAG
AATGTATTTAGTACGACTGTAAGCAGTGGTTATAACACCAAAAAAATAGGCAAGAGGCTT
AATATCCAGCTTAAGAAAGGTACAGAAGGTTTGGGATTCAGCATCACTTCCAGAGATGTA
ACAATAGGTGGCTCAGCTCCAATCTATGTGAAAAACATTCTCCCCCGGGGGGCGGCCATT
CAGGATGGCCGACTTAAGGCAGGAGACAGACTTATAGAGGTAAATGGAGTAGATTTAGTG
GGCAAATCCCAAGAGGAAGTTGTTTCGCTGTTGAGAAGCACCAAGATGGAAGGAACTGTG
AGCCTTCTGGTCTTTCGCCAGGAAGACGCCTTCCACCCAAGGGAACTGAATGCAGAGCCA
AGCCAGATGCAGATTCCAAAAGAAACGAAAGCAGAAGATGAGGATATTGTTCTTACACCT
GATGGCACCAGGGAATTTCTGACATTTGAAGTCCCACTTAATGATTCAGGATCTGCAGGC
CTTGGTGTCAGTGTCAAAGGTAACCGGTCAAAAGAGAACCACGCAGATTTGGGAATCTTT
GTCAAGTCCATTATTAATGGAGGAGCAGCATCTAAAGATGGAAGGCTTCGGGTGAATGAT
CAACTGATAGCAGTAAATGGAGAATCCCTGTTGGGCAAGACAAACCAAGATGCCATGGAA
ACCCTAAGAAGGTCTATGTCTACTGAAGGCAATAAACGAGGAATGATCCAGCTTATTGTT
GCAAGGAGAATAAGCAAGTGCAATGAGCTGAAGTCACCTGGGAGCCCCCCTGGACCTGAG
CTGCCCATTGAAACAGCGTTGGATGATAGAGAACGAAGAATTTCCCATTCCCTCTACAGT
GGGATTGAGGGGCTTGATGAATCGCCCAGCAGAAATGCTGCCCTCAGTAGGATAATGGGT
GAGTCAGGTAAATACCAGCTGTCCCCTACAGTGAATATGCCCCAAGATGACACTGTCATT
ATAGAAGATGACAGGTTGCCAGTGCTTCCTCCACATCTCTCTGACCAGTCCTCTTCCAGC
TCCCATGATGATGTGGGGTTTGTGACGGCAGATGCTGGTACTTGGGCCAAGGCTGCAATC
AGTGATTCAGCCGACTGCTCTTTGAGTCCAGATGTTGATCCAGTTCTTGCTTTTCAACGA
GAAGGATTTGGACGTCAGAGTATGTCAGAAAAACGCACAAAGCAATTTTCAGATGCCAGT
CAATTGGATTTCGTTAAAACACGAAAATCAAAAAGCATGGATTTAGGTATAGCTGACGAG
ACTAAACTCAATACAGTGGATGACCAGAAAGCAGGTTCTCCCAGCAGAGATGTGGGTCCT
TCCCTGGGTCTGAAGAAGTCAAGCTCGTTGGAGAGTCTGCAGACCGCAGTTGCCGAGGTG
ACTTTGAATGGGGATATTCCTTTCCATCGTCCACGGCCGCGGATAATCAGAGGCAGGGGA
TGCAATGAGAGCTTCAGAGCTGCCATCGACAAATCTTATGATAAACCCGCGGTAGATGAT
GATGATGAAGGCATGGAGACCTTGGAAGAAGACACAGAAGAAAGTTCAAGATCAGGGAGA
GAGTCTGTATCCACAGCCAGTGATCAGCCTTCCCACTCTCTGGAGAGACAAATGAATGGA
AACCAAGAGAAAGGTGATAAGACTGATAGAAAAAAGGATAAAACTGGAAAAGAAAAGAAG
AAAGATAGAGATAAGGAGAAGGATAAAATGAAAGCCAAGAAGGGAATGCTGAAGGGCTTG
GGAGACATGTTCAGGTTTGGCAAACATCGAAAAGATGACAAGATTGAGAAAACGGGTAAA
ATAAAAATACAGGAATCCTTTACATCAGAAGAGGAGAGGATACGAATGAAGCAGGAGCAG
GAGAGGATTCAAGCCAAAACTCGAGAATTTAGGGAACGACAAGCTCGAGAGCGTGACTAT
GCTGAAATTCAAGATTTTCATCGGACATTTGGCTGTGATGATGAGTTAATGTATGGGGGA
GTTTCTTCTTATGAAGGTTCCATGGCTCTCAACGCTAGACCTCAGAGCCCACGAGAAGGG
CATATGATGGATGCTTTGTATGCCCAAGTCAAGAAGCCGCGGAATTCCAAACCCTCACCT
GTAGACAGTAACAGATCAACTCCTAGCAATCATGATCGGATACAGCGTCTGAGGCAAGAA
TTTCAGCAAGCAAAGCAAGATGAAGATGTAGAAGATCGTCGGCGGACCTATAGTTTTGAG
CAACCCTGGCCGAACGCACGGCCGGCGACGCAGAGCGGGCGACACTCGGTGTCCGTGGAG
GTGCAGATGCAGCGGCAGCGGCAGGAGGAGCGCGAGAGCTCCCAGCAGGCCCAGCGCCAG
TACAGCTCTCTGCCTCGGCAAAGCAGGAAAAATGCCAGCTCGGTCTCCCAGGACTCTTGG
GAGCAGAACTACTCCCCTGGGGAAGGCTTCCAGAGTGCCAAAGAGAACCCCAGGTACTCC
AGCTACCAAGGCTCCAGGAACGGCTACCTGGGAGGACATGGCTTCAACGCCAGGGTCATG
CTGGAAACTCAGGAGCTCCTTCGCCAGGAACAGAGGCGGAAGGAGCAGCAGATGAAGAAG
CAGCCTCCTTCCGAGGGGCCCAGCAACTATGACTCGTATAAGAAAGTCCAGGACCCCAGT
TACGCCCCTCCCAAGGGGCCCTTCCGGCAAGATGTGCCCCCCTCCCCTTCTCAGGTTGCG
AGGCTGAACAGACTTCAGACTCCTGAGAAAGGGAGGCCCTTCTATTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1356 |
| Molecular Weight
| 151422.0 |
| Theoretical pI
| 7.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Partitioning defective 3 homolog
MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD
LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ
ATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFL
KQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASHPMVGKWLEKQEQDE
DGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLG
LLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA
ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSR
LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDV
TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV
SLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAG
LGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAME
TLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYS
GIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSS
SHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDAS
QLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEV
TLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGR
ESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKGL
GDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQARERDY
AEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPSP
VDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPNARPATQSGRHSVSVE
VQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRYS
SYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPS
YAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS
|
| External Links |
|---|
| GenBank ID Protein
| 21361831 |
| UniProtKB/Swiss-Prot ID
| Q8TEW0 |
| UniProtKB/Swiss-Prot Entry Name
| PARD3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_019619.3 |
| GeneCard ID
| PARD3 |
| GenAtlas ID
| PARD3 |
| HGNC ID
| HGNC:16051 |
| References |
|---|
| General References
| Not Available |