| Identification |
|---|
| HMDB Protein ID
| CDBP03713 |
| Secondary Accession Numbers
| Not Available |
| Name
| Partitioning defective 6 homolog beta |
| Description
| Not Available |
| Synonyms
|
- PAR-6 beta
- PAR-6B
|
| Gene Name
| PARD6B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Cell junction
- tight junction
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q13.13 |
| SNPs
| PARD6B |
| Gene Sequence
|
>1119 bp
ATGAACCGCAGCCACCGGCACGGGGCGGGCAGCGGCTGCCTGGGCACTATGGAGGTGAAG
AGCAAGTTTGGAGCTGAATTTCGTCGGTTTTCGCTGGAAAGATCAAAACCTGGAAAATTT
GAGGAGTTTTATGGATTACTACAACATGTTCATAAGATCCCCAATGTTGACGTTTTGGTA
GGCTATGCAGACATCCATGGAGACTTACTACCTATAAATAATGATGATAATTATCACAAA
GCTGTTTCAACGGCCAATCCACTGCTTAGGATATTTATACAAAAGAAGGAAGAAGCAGAC
TACAGTGCCTTTGGTACAGACACGCTAATAAAGAAGAAGAATGTTTTAACCAACGTATTG
CGTCCTGACAACCATAGAAAAAAGCCACATATAGTCATTAGTATGCCCCAAGACTTTAGA
CCTGTGTCTTCTATTATAGACGTGGATATTCTCCCAGAAACGCATCGTAGGGTACGTCTT
TACAAATACGGCACGGAGAAACCCCTAGGATTCTACATCCGGGATGGCTCCAGTGTCAGG
GTAACACCACATGGCTTAGAAAAGGTTCCAGGGATCTTTATATCCAGGCTTGTCCCAGGA
GGTCTGGCTCAAAGTACAGGACTATTAGCTGTTAATGATGAAGTTTTAGAAGTTAATGGC
ATAGAAGTTTCAGGGAAGAGCCTTGATCAAGTAACAGACATGATGATTGCAAATAGCCGT
AACCTCATCATAACAGTGAGACCGGCAAACCAGAGGAATAATGTTGTGAGGAACAGTCGG
ACTTCTGGCAGTTCCGGTCAGTCTACTGATAACAGCCTTCTTGGCTACCCACAGCAGATT
GAACCAAGCTTTGAGCCAGAGGATGAAGACAGCGAAGAAGATGACATTATCATTGAAGAC
AATGGAGTGCCACAGCAGATTCCAAAAGCTGTTCCTAATACTGAGAGCCTGGAGTCATTA
ACACAGATAGAGCTAAGCTTTGAGTCTGGACAGAATGGCTTTATTCCCTCTAATGAAGTG
AGCTTAGCAGCCATAGCAAGCAGCTCAAACACGGAATTTGAAACACATGCTCCAGATCAA
AAACTCTTAGAAGAAGATGGAACAATCATAACATTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 372 |
| Molecular Weight
| 41181.9 |
| Theoretical pI
| 5.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Partitioning defective 6 homolog beta
MNRSHRHGAGSGCLGTMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLV
GYADIHGDLLPINNDDNYHKAVSTANPLLRIFIQKKEEADYSAFGTDTLIKKKNVLTNVL
RPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVR
VTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSR
NLIITVRPANQRNNVVRNSRTSGSSGQSTDNSLLGYPQQIEPSFEPEDEDSEEDDIIIED
NGVPQQIPKAVPNTESLESLTQIELSFESGQNGFIPSNEVSLAAIASSSNTEFETHAPDQ
KLLEEDGTIITL
|
| External Links |
|---|
| GenBank ID Protein
| 13537117 |
| UniProtKB/Swiss-Prot ID
| Q9BYG5 |
| UniProtKB/Swiss-Prot Entry Name
| PAR6B_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB044555 |
| GeneCard ID
| PARD6B |
| GenAtlas ID
| PARD6B |
| HGNC ID
| HGNC:16245 |
| References |
|---|
| General References
| Not Available |