Showing Protein 2'-5'-oligoadenylate synthase 3 (CDBP03706)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03706
Secondary Accession Numbers Not Available
Name 2'-5'-oligoadenylate synthase 3
Description Not Available
Synonyms
  1. (2-5')oligo(A) synthase 3
  2. 2-5A synthase 3
  3. p100 OAS
  4. p100OAS
Gene Name OAS3
Protein Type Enzyme
Biological Properties
General Function Involved in RNA binding
Specific Function May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate
GO Classification
Function
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
nucleotidyltransferase activity
nucleic acid binding
rna binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
Process
immune system process
immune response
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12q24.2
SNPs OAS3
Gene Sequence 
>3264 bp
ATGGACTTGTACAGCACCCCGGCCGCTGCGCTGGACAGGTTCGTGGCCAGAAAGCTGCAG
CCGCGGAAGGAGTTCGTAGAGAAGGCGCGGCGCGCTCTGGGCGCCCTGGCCGCTGCTCTG
AGGGAGCGCGGGGGCCGCCTCGGTGCTGCTGCCCCGCGGGTGCTGAAAACTGTCAAGGGA
GGCTCCTCGGGCCGGGGCACAGCTCTCAAGGGTGGCTGTGATTCTGAACTTGTCATCTTC
CTCGACTGCTTCAAGAGCTATGTGGACCAGAGGGCCCGCCGTGCAGAGATCCTCAGTGAG
ATGCGGGCATCGCTGGAATCCTGGTGGCAGAACCCAGTCCCTGGTCTGAGACTCACGTTT
CCTGAGCAGAGCGTGCCTGGGGCCCTGCAGTTCCGCCTGACATCCGTAGATCTTGAGGAC
TGGATGGATGTTAGCCTGGTGCCTGCCTTCAATGTCCTGGGTCAGGCCGGCTCCGGCGTC
AAACCCAAGCCACAAGTCTACTCTACCCTCCTCAACAGTGGCTGCCAAGGGGGCGAGCAT
GCGGCCTGCTTCACAGAGCTGCGGAGGAACTTTGTGAACATTCGCCCAGCCAAGTTGAAG
AACCTAATCTTGCTGGTGAAGCACTGGTACCACCAGGTGTGCCTACAGGGGTTGTGGAAG
GAGACGCTGCCCCCGGTCTATGCCCTGGAATTGCTGACCATCTTCGCCTGGGAGCAGGGC
TGTAAGAAGGATGCTTTCAGCCTAGCCGAAGGCCTCCGAACTGTCCTGGGCCTGATCCAA
CAGCATCAGCACCTGTGTGTTTTCTGGACTGTCAACTATGGCTTCGAGGACCCTGCAGTT
GGGCAGTTCTTGCAGCGGCAGCTTAAGAGACCCAGGCCTGTGATCCTGGACCCAGCTGAC
CCCACATGGGACCTGGGGAATGGGGCAGCCTGGCACTGGGATTTGCTAGCCCAGGAGGCA
GCATCCTGCTATGACCACCCATGCTTTCTGAGGGGGATGGGGGACCCAGTGCAGTCTTGG
AAGGGGCCGGGCCTTCCACGTGCTGGATGCTCAGGTTTGGGCCACCCCATCCAGCTAGAC
CCTAACCAGAAGACCCCTGAAAACAGCAAGAGCCTCAATGCTGTGTACCCAAGAGCAGGG
AGCAAACCTCCCTCATGCCCAGCTCCTGGCCCCACTGGGGCAGCCAGCATCGTCCCCTCT
GTGCCGGGAATGGCCTTGGACCTGTCTCAGATCCCCACCAAGGAGCTGGACCGCTTCATC
CAGGACCACCTGAAGCCGAGCCCCCAGTTCCAGGAGCAGGTGAAAAAGGCCATCGACATC
ATCTTGCGCTGCCTCCATGAGAACTGTGTTCACAAGGCCTCAAGAGTCAGTAAAGGGGGC
TCATTTGGCCGGGGCACAGACCTAAGGGATGGCTGTGATGTTGAACTCATCATCTTCCTC
AACTGCTTCACGGACTACAAGGACCAGGGGCCCCGCCGCGCAGAGATCCTTGATGAGATG
CGAGCGCACGTAGAATCCTGGTGGCAGGACCAGGTGCCCAGCCTGAGCCTTCAGTTTCCT
GAGCAGAATGTGCCTGAGGCTCTGCAGTTCCAGCTGGTGTCCACAGCCCTGAAGAGCTGG
ACGGATGTTAGCCTGCTGCCTGCCTTCGATGCTGTGGGGCAGCTCAGTTCTGGCACCAAA
CCAAATCCCCAGGTCTACTCAAGGCTCCTCACCAGTGGCTGCCAGGAGGGCGAGCATAAG
GCCTGCTTCGCAGAGCTGCGGAGGAACTTCATGAACATTCGCCCTGTCAAGCTGAAGAAC
CTGATTCTGCTGGTGAAGCACTGGTACCGCCAGGTTGCGGCTCAGAACAAAGGAAAAGGA
CCAGCCCCTGCCTCTCTGCCCCCAGCCTATGCCCTGGAGCTCCTCACCATCTTTGCCTGG
GAGCAGGGCTGCAGGCAGGATTGTTTCAACATGGCCCAAGGCTTCCGGACGGTGCTGGGG
CTCGTGCAACAGCATCAGCAGCTCTGTGTCTACTGGACGGTCAACTATAGCACTGAGGAC
CCAGCCATGAGAATGCACCTTCTTGGCCAGCTTCGAAAACCCAGACCCCTGGTCCTGGAC
CCCGCTGATCCCACCTGGAACGTGGGCCACGGTAGCTGGGAGCTGTTGGCCCAGGAAGCA
GCAGCGCTGGGGATGCAGGCCTGCTTTCTGAGTAGAGACGGGACATCTGTGCAGCCCTGG
GATGTGATGCCAGCCCTCCTTTACCAAACCCCAGCTGGGGACCTTGACAAGTTCATCAGT
GAATTTCTCCAGCCCAACCGCCAGTTCCTGGCCCAGGTGAACAAGGCCGTTGATACCATC
TGTTCATTTTTGAAGGAAAACTGCTTCCGGAATTCTCCCATCAAAGTGATCAAGGTGGTC
AAGGGTGGCTCTTCAGCCAAAGGCACAGCTCTGCGAGGCCGCTCAGATGCCGACCTCGTG
GTGTTCCTCAGCTGCTTCAGCCAGTTCACTGAGCAGGGCAACAAGCGGGCCGAGATCATC
TCCGAGATCCGAGCCCAGCTGGAGGCATGTCAACAGGAGCGGCAGTTCGAGGTCAAGTTT
GAAGTCTCCAAATGGGAGAATCCCCGCGTGCTGAGCTTCTCACTGACATCCCAGACGATG
CTGGACCAGAGTGTGGACTTTGATGTGCTGCCAGCCTTTGACGCCCTAGGCCAGCTGGTC
TCTGGCTCCAGGCCCAGCTCTCAAGTCTACGTCGACCTCATCCACAGCTACAGCAATGCG
GGCGAGTACTCCACCTGCTTCACAGAGCTACAACGGGACTTCATCATCTCTCGCCCTACC
AAGCTGAAGAGCCTGATCCGGCTGGTGAAGCACTGGTACCAGCAGTGTACCAAGATCTCC
AAGGGGAGAGGCTCCCTACCCCCACAGCACGGGCTGGAACTCCTGACTGTGTATGCCTGG
GAGCAGGGCCGGAAGGACTCCCAGTTCAACATGGCTGAGGGCTTCCGCACGGTCCTGGAG
CTGGTCACCCAGTACCGCCAGCTCTGTATCTACTGGACCATCAACTACAACGCCAAGGAC
AAGACTGTTGGAGACTTCCTGAAACAGCAGCTTCAGAAGCCCAGGCCTATCATCCTGGAT
CCGGCTGACCCGACAGGCAACCTGGGCCACAATGCCCGCTGGGACCTGCTGGCCAAGGAA
GCTGCAGCCTGCACATCTGCCCTGTGCTGCATGGGACGGAATGGCATCCCCATCCAGCCA
TGGCCAGTGAAGGCTGCTGTGTGA
Protein Properties
Number of Residues 1087
Molecular Weight 121164.1
Theoretical pI 8.47
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>2'-5'-oligoadenylate synthase 3
MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG
GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF
PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGCQGGEH
AACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQG
CKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPAD
PTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLD
PNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFI
QDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSFGRGTDLRDGCDVELIIFL
NCFTDYKDQGPRRAEILDEMRAHVESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSW
TDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKN
LILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLG
LVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEA
AALGMQACFLSRDGTSVQPWDVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTI
CSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEII
SEIRAQLEACQQERQFEVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLV
SGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKIS
KGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKD
KTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQP
WPVKAAV
GenBank ID Protein 11527773
UniProtKB/Swiss-Prot ID Q9Y6K5
UniProtKB/Swiss-Prot Entry Name OAS3_HUMAN
PDB IDs Not Available
GenBank Gene ID AB044545
GeneCard ID OAS3
GenAtlas ID OAS3
HGNC ID HGNC:8088
References
General References Not Available