| Identification |
|---|
| HMDB Protein ID
| CDBP03690 |
| Secondary Accession Numbers
| Not Available |
| Name
| Large subunit GTPase 1 homolog |
| Description
| Not Available |
| Synonyms
|
- hLsg1
|
| Gene Name
| LSG1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable) |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Endoplasmic reticulum
- Cajal body
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q29 |
| SNPs
| LSG1 |
| Gene Sequence
|
>1977 bp
ATGGGCCGGAGGAGAGCCCCGGCCGGTGGGTCGCTGGGACGGGCCCTTATGCGCCATCAG
ACTCAGCGGAGCCGAAGCCATCGTCACACTGACTCCTGGTTGCACACAAGTGAACTCAAT
GATGGCTATGATTGGGGTCGTCTTAATCTTCAGTCAGTGACTGAACAGAGCTCCCTTGAT
GACTTCCTTGCTACTGCAGAACTTGCAGGAACAGAGTTTGTAGCTGAGAAACTTAATATT
AAGTTTGTGCCTGCTGAGGCTAGAACTGGACTACTGTCTTTCGAGGAGAGCCAGAGAATT
AAGAAGCTCCATGAAGAAAACAAACAGTTCTTGTGTATACCGAGGAGACCAAACTGGAAC
CAAAATACTACCCCAGAAGAACTCAAACAAGCAGAGAAAGATAACTTTCTAGAATGGAGA
CGTCAGCTTGTCCGGCTAGAAGAGGAACAGAAGCTGATATTGACTCCATTTGAACGAAAT
TTGGACTTTTGGCGCCAGCTCTGGAGAGTCATTGAGAGAAGTGATATTGTGGTCCAGATA
GTAGATGCTCGAAACCCACTCCTGTTTAGATGTGAGGATTTGGAATGTTATGTGAAAGAA
ATGGATGCCAATAAGGAGAACGTCATTCTGATCAACAAGGCAGACTTGCTGACTGCTGAG
CAGCGGAGTGCCTGGGCCATGTACTTCGAAAAAGAAGATGTGAAGGTTATTTTCTGGTCA
GCTTTGGCCGGAGCCATTCCCCTGAATGGTGACTCTGAGGAAGAGGCAAACAGAGATGAT
AGACAAAGCAACACAACCAAGTTTGGACATTCCAGTTTCGACCAGGCTGAAATTTCCCAC
AGTGAATCCGAACATCTCCCAGCTAGGGATTCTCCTTCACTTAGTGAAAATCCCACAACG
GATGAAGATGACAGTGAGTATGAGGACTGTCCAGAGGAGGAGGAAGACGACTGGCAGACG
TGCTCAGAAGAAGACGGTCCCAAGGAAGAGGACTGCAGCCAGGACTGGAAGGAAAGCTCT
ACTGCAGATTCTGAGGCTCGGAGCAGGAAAACCCCACAGAAGAGGCAGATACACAATTTT
AGCCATCTGGTATCCAAGCAGGAGTTACTGGAGCTCTTTAAGGAGCTACACACTGGGAGA
AAGGTGAAAGATGGGCAACTTACGGTCGGACTGGTGGGCTACCCTAATGTTGGTAAGAGT
TCAACAATCAACACCATCATGGGCAACAAGAAAGTATCTGTGTCTGCCACACCTGGTCAC
ACAAAGCACTTTCAGACTCTCTATGTGGAGCCTGGCCTCTGCCTGTGTGACTGTCCTGGC
TTGGTGATGCCATCTTTTGTGTCTACCAAGGCAGAAATGACTTGCAGCGGAATCCTCCCA
ATTGATCAGATGAGAGATCATGTTCCTCCTGTATCACTAGTTTGCCAGAATATTCCAAGA
CATGTTTTAGAAGCTACCTATGGCATTAACATCATAACGCCTAGAGAGGATGAAGATCCC
CACCGACCTCCAACATCGGAAGAACTGTTGACAGCTTATGGATACATGCGAGGATTCATG
ACAGCGCATGGACAGCCAGACCAGCCTCGATCTGCGCGCTACATCCTGAAGGACTATGTC
AGTGGTAAGCTGCTGTACTGCCATCCTCCTCCTGGAAGAGATCCTGTAACTTTTCAGCAT
CAACACCAGCGACTCCTAGAGAACAAAATGAACAGTGATGAAATAAAAATGCAGCTAGGC
AGAAATAAAAAAGCAAAGCAGATTGAAAATATCGTTGACAAAACTTTTTTCCATCAAGAG
AATGTGAGGGCTTTGACCAAAGGAGTCCAGGCTGTGATGGGTTACAAGCCCGGGAGTGGT
GTAGTGACTGCATCCACTGCGAGCTCTGAGAACGGGGCGGGGAAGCCCTGGAAAAAACAT
GGCAACAGAAATAAAAAAGAAAAAAGTCGTAGACTCTACAAGCACCTGGATATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 658 |
| Molecular Weight
| 75224.8 |
| Theoretical pI
| 6.34 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Large subunit GTPase 1 homolog
MGRRRAPAGGSLGRALMRHQTQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLD
DFLATAELAGTEFVAEKLNIKFVPAEARTGLLSFEESQRIKKLHEENKQFLCIPRRPNWN
QNTTPEELKQAEKDNFLEWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQI
VDARNPLLFRCEDLECYVKEMDANKENVILINKADLLTAEQRSAWAMYFEKEDVKVIFWS
ALAGAIPLNGDSEEEANRDDRQSNTTKFGHSSFDQAEISHSESEHLPARDSPSLSENPTT
DEDDSEYEDCPEEEEDDWQTCSEEDGPKEEDCSQDWKESSTADSEARSRKTPQKRQIHNF
SHLVSKQELLELFKELHTGRKVKDGQLTVGLVGYPNVGKSSTINTIMGNKKVSVSATPGH
TKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMTCSGILPIDQMRDHVPPVSLVCQNIPR
HVLEATYGINIITPREDEDPHRPPTSEELLTAYGYMRGFMTAHGQPDQPRSARYILKDYV
SGKLLYCHPPPGRDPVTFQHQHQRLLENKMNSDEIKMQLGRNKKAKQIENIVDKTFFHQE
NVRALTKGVQAVMGYKPGSGVVTASTASSENGAGKPWKKHGNRNKKEKSRRLYKHLDM
|
| External Links |
|---|
| GenBank ID Protein
| 223029424 |
| UniProtKB/Swiss-Prot ID
| Q9H089 |
| UniProtKB/Swiss-Prot Entry Name
| LSG1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018385.2 |
| GeneCard ID
| LSG1 |
| GenAtlas ID
| LSG1 |
| HGNC ID
| HGNC:25652 |
| References |
|---|
| General References
| Not Available |