Cannabis Compound Database: Showing Protein NF-kappa-B inhibitor-interacting Ras-like protein 2 (CDBP03687)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03687

Secondary Accession Numbers

Not Available

Name

NF-kappa-B inhibitor-interacting Ras-like protein 2

Description

Not Available

Synonyms

I-kappa-B-interacting Ras-like protein 2
Kappa B-Ras protein 2
KappaB-Ras2

Gene Name

NKIRAS2

Protein Type

Enzyme

Biological Properties

General Function

Involved in GTP binding

Specific Function

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB

GO Classification

Function
purine nucleotide binding
binding
nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
Process
small gtpase mediated signal transduction
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signal transduction

Cellular Location

Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

17q21.2

SNPs

NKIRAS2

Gene Sequence

>576 bp
ATGGGGAAGAGCTGCAAGGTGGTCGTGTGTGGCCAGGCGTCTGTGGGCAAAACTTCAATC
CTGGAGCAGCTTCTGTATGGGAACCATGTAGTGGGTTCGGAGATGATCGAGACGCAGGAG
GACATCTACGTGGGCTCCATTGAGACAGACCGGGGGGTGCGAGAGCAGGTGCGTTTCTAT
GACACCCGGGGGCTCCGAGATGGGGCCGAACTGCCCCGACACTGCTTCTCTTGCACTGAT
GGCTACGTCCTGGTCTATAGCACAGATAGCAGAGAGTCTTTTCAGCGTGTGGAGCTGCTC
AAGAAGGAGATTGACAAATCCAAGGACAAGAAGGAGGTCACCATCGTGGTCCTTGGCAAC
AAGTGTGACTTACAGGAGCAGCGGCGTGTAGACCCAGATGTGGCTCAGCACTGGGCCAAG
TCAGAGAAGGTGAAGCTGTGGGAGGTGTCAGTGGCGGACCGGCGCTCCCTCCTGGAGCCC
TTTGTCTACTTGGCCAGCAAGATGACGCAACCCCAGAGCAAGTCTGCCTTCCCCCTCAGC
CGGAAGAACAAGGGCAGCGGCTCCTTGGATGGCTGA

Protein Properties

Number of Residues

191

Molecular Weight

21508.3

Theoretical pI

8.2

Pfam Domain Function

Ras (PF00071 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>NF-kappa-B inhibitor-interacting Ras-like protein 2
MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQVRFY
DTRGLRDGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGN
KCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPLS
RKNKGSGSLDG

External Links

GenBank ID Protein

47777758

UniProtKB/Swiss-Prot ID

Q9NYR9

UniProtKB/Swiss-Prot Entry Name

KBRS2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001001349.2

GeneCard ID