| Identification |
|---|
| HMDB Protein ID
| CDBP03677 |
| Secondary Accession Numbers
| Not Available |
| Name
| Importin-13 |
| Description
| Not Available |
| Synonyms
|
- Imp13
- Kap13
- Karyopherin-13
- Ran-binding protein 13
- RanBP13
|
| Gene Name
| IPO13 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 |
| GO Classification
|
| Function |
| binding |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p34.1 |
| SNPs
| IPO13 |
| Gene Sequence
|
>2892 bp
ATGGAGCGGCGGGAGGAGCAGCCGGGGGCTGCAGGGGCTGGAGCAGCACCAGCCTTGGAC
TTCACTGTGGAGAACGTGGAGAAGGCGCTGCACCAGCTCTACTATGATCCCAACATTGAG
AATAAGAACCTGGCTCAGAAGTGGCTGATGCAGGCCCAGGTCTCCCCACAGGCCTGGCAC
TTCAGCTGGCAGCTACTGCAGCCCGACAAGGTACCAGAGATCCAGTACTTTGGGGCCAGT
GCTCTTCACATCAAGATCTCTCGCTACTGGAGTGACATCCCCACTGACCAGTATGAAAGC
CTAAAGGCACAGCTCTTCACCCAGATCACCCGCTTTGCCAGTGGCTCCAAGATTGTACTG
ACTCGGCTGTGCGTGGCACTGGCCTCACTGGCTCTCAGCATGATGCCTGACGCTTGGCCA
TGTGCTGTGGCAGATATGGTACGACTCTTCCAGGCTGAGGACTCACCAGTGGATGGGCAG
GGCCGCTGCCTAGCCCTGTTAGAGCTGCTGACAGTGCTGCCTGAGGAGTTCCAGACCAGT
CGCCTACCCCAGTACCGCAAAGGCCTGGTGCGGACCAGCCTGGCGGTGGAATGTGGGGCT
GTCTTCCCGCTGCTGGAGCAGCTGCTACAGCAGCCCAGCTCACCCAGCTGTGTGCGTCAG
AAGGTGCTCAAGTGTTTCTCCAGCTGGGTGCAGCTGGAGGTGCCGCTGCAGGACTGTGAG
GCGCTCATTCAGGCTGCCTTTGCTGCTCTGCAGGACTCGGAGCTCTTCGACAGCAGTGTG
GAGGCCATTGTGAATGCCATCTCACAGCCTGATGCCCAGAGGTACGTGAACACACTCCTG
AAACTCATCCCGCTGGTGCTGGGTCTGCAGGAACAACTGCGGCAGGCAGTGCAGAATGGG
GACATGGAGACCTCCCATGGCATCTGTCGCATCGCTGTGGCCCTGGGCGAGAACCACTCC
CGGGCCTTGCTGGACCAAGTAGAGCACTGGCAGAGTTTCCTGGCACTCGTCAACATGATT
ATGTTCTGCACAGGCATCCCTGGCCACTATCCTGTCAATGAGACCACCAGCTCCCTAACC
CTCACCTTCTGGTACACACTGCAGGATGATATTCTATCCTTTGAGGCAGAGAAGCAGGCT
GTATACCAGCAGGTGTACCGGCCAGTCTACTTCCAGCTGGTGGATGTGCTTCTGCACAAG
GCCCAGTTCCCTTCTGATGAGGAATATGGATTCTGGTCCTCAGACGAGAAGGAGCAGTTC
CGAATTTACAGGGTGGACATCTCAGACACGCTCATGTATGTCTATGAGATGTTGGGGGCC
GAGCTGCTCAGCAACCTCTATGACAAGCTGGGTCGTTTGCTCACCAGCTCAGAGGAGCCC
TACTCCTGGCAGCACACAGAGGCCCTCCTCTACGGCTTCCAATCCATCGCAGAGACCATT
GACGTCAACTATTCTGATGTGGTGCCTGGGCTCATTGGCCTCATCCCACGGATCAGCATC
AGCAACGTGCAGCTGGCAGACACTGTCATGTTCACCATTGGAGCTCTGTCTGAATGGCTG
GCTGACCACCCCGTCATGATCAACAGTGTTCTGCCCTTGGTACTGCATGCCCTAGGCAAT
CCTGAGCTGTCTGTCTCTTCTGTGTCCACCCTCAAGAAGATCTGCCGAGAGTGCAAGTAT
GACCTGCCTCCCTATGCTGCCAACATTGTGGCTGTGTCCCAGGATGTGCTGATGAAACAG
ATCCACAAGACAAGCCAGTGCATGTGGCTGATGCAGGCGCTGGGCTTCCTGCTGTCAGCT
CTTCAAGTGGAGGAGATCCTTAAGAACCTGCACTCGCTTATCTCACCCTATATCCAGCAA
CTGGAGAAGCTGGCAGAGGAGATACCCAATCCCTCCAACAAGCTGGCCATTGTTCACATC
TTGGGGCTTCTCTCCAACCTCTTCACCACACTGGACATCAGTCATCATGAGGATGATCAT
GAAGGCCCTGAGCTTCGGAAGCTGCCAGTGCCACAGGGACCCAACCCCGTGGTGGTGGTG
CTGCAGCAGGTCTTCCAGCTTATCCAGAAGGTGCTGAGCAAATGGTTGAATGATGCCCAG
GTTGTGGAGGCGGTGTGCGCTATCTTTGAGAAGTCTGTTAAGACGCTGCTGGATGACTTT
GCCCCCATGGTGCCACAGCTGTGTGAGATGCTGGGTCGGATGTACAGCACCATCCCCCAG
GCCTCTGCTCTTGACCTCACTCGACAGCTGGTCCACATCTTTGCTCATGAGCCTGCCCAC
TTTCCCCCAATTGAGGCCCTCTTCCTGCTCGTCACCTCCGTCACACTCACTCTCTTCCAG
CAAGGGCCCAGGGATCATCCTGATATTGTTGATTCATTTATGCAACTCCTGGCACAGGCT
CTGAAGCGGAAGCCAGATTTGTTCCTGTGTGAACGATTGGATGTCAAAGCTGTGTTCCAG
TGTGCTGTGCTGGCCCTCAAGTTCCCTGAGGCACCTACTGTCAAGGCCTCCTGTGGCTTC
TTTACAGAGCTGCTGCCTCGGTGTGGGGAAGTAGAGTCTGTGGGAAAGGTGGTACAGGAA
GACGGTCGTATGCTGCTCATAGCAGTGCTGGAGGCCATTGGGGGCCAGGCCTCCCGCAGC
CTCATGGACTGCTTTGCCGATATCCTGTTCGCCCTGAACAAGCACTGCTTCAGCCTCCTG
AGCATGTGGATCAAGGAGGCCCTGCAGCCACCTGGTTTCCCCTCTGCCCGCCTCAGCCCT
GAACAGAAGGATACCTTCAGCCAGCAGATCCTTCGCGAGCGAGTGAACAAGAGGCGGGTG
AAGGAGATGGTGAAGGAGTTCACACTGCTGTGCCGGGGTCTCCATGGCACAGATTACACA
GCTGACTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 963 |
| Molecular Weight
| 108194.1 |
| Theoretical pI
| 4.95 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Importin-13
MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWH
FSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVL
TRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTS
RLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCE
ALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNG
DMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLT
LTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQF
RIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETI
DVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGN
PELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSA
LQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDH
EGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDF
APMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQ
QGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGF
FTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLL
SMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYT
ADY
|
| External Links |
|---|
| GenBank ID Protein
| 224831257 |
| UniProtKB/Swiss-Prot ID
| O94829 |
| UniProtKB/Swiss-Prot Entry Name
| IPO13_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014652.3 |
| GeneCard ID
| IPO13 |
| GenAtlas ID
| IPO13 |
| HGNC ID
| HGNC:16853 |
| References |
|---|
| General References
| Not Available |