Cannabis Compound Database: Showing Protein Importin-11 (CDBP03676)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03676

Secondary Accession Numbers

Not Available

Name

Importin-11

Description

Not Available

Synonyms

Imp11
Ran-binding protein 11
RanBP11

Gene Name

IPO11

Protein Type

Transporter

Biological Properties

General Function

Involved in binding

Specific Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12

GO Classification

Function
binding
protein transporter activity
transporter activity
substrate-specific transporter activity
Process
establishment of localization
transport
protein transport
intracellular protein transport

Cellular Location

Nucleus
Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q12.1

SNPs

IPO11

Gene Sequence

>2928 bp
ATGGATCTCAATAGTGCCAGCACTGTTGTTCTTCAGGTGTTAACACAGGCCACCAGTCAG
GATACTGCTGTGTTAAAACCAGCTGAGGAGCAGTTGAAGCAGTGGGAGACACAGCCAGGT
TTCTATTCAGTGTTGCTGAATATTTTCACCAACCACACTTTGGATATAAATGTAAGGTGG
CTTGCTGTACTGTATTTTAAACATGGAATTGATCGCTACTGGAGACGTGTAGCACCTCAT
GCTCTCTCAGAGGAGGAGAAAACTACTCTGCGTGCAGGGCTCATCACCAACTTCAATGAA
CCAATAAACCAGATTGCAACTCAGATTGCAGTGCTCATTGCAAAAGTTGCTAGATTGGAT
TGTCCCAGACAGTGGCCTGAACTAATTCCCACTCTTATAGAGTCTGTTAAAGTCCAGGAT
GATCTTCGACAGCACAGAGCATTACTTACCTTCTATCATGTTACCAAGACACTGGCATCT
AAACGACTTGCTGCTGATAGAAAACTATTTTATGATTTAGCTTCTGGAATTTATAATTTT
GCCTGCTCTCTGTGGAATCACCACACAGACACATTCCTGCAAGAAGTTTCTTCTGGCAAT
GAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTAAG
TTAACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACAT
GGAATATTTGAACGTCTAAAACAGTTTCTGGAATGCAGTAGAAGTATAGGTACAGATAAT
GTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACTTC
TTGGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTA
AGCTATGTTTTTACAGAAGTTGGTGAAGGCGTTACATTTGAACGATTCATTGTCCAATGT
ATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTGAA
GATAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCT
ACTTTGACAGAGATATGTAGAAGATTAGTCTCTCATTATTTCCTATTAACTGAAGAAGAA
CTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATTCT
TGGAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATAT
AATCAGACTCTTACTCCTGTACTTCTAGAAATGATGCAAACACTTCAAGGACCCACAAAT
GTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAGCT
GCTTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCA
GAATTACAAGTCATTCACAATAGGTATAAGCCATTGCGACGCAGGGTGATTTGGCTCATC
GGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAATC
TGTAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAG
TTAACTGTTGATGATTTTGAATTTAGAACAGATCAGTTTCTACCGTATTTGGAAACCATG
TTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATGTT
TTGCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGA
TGTTTGGTACAATATTTGCCCCTCCTTTGGAAGCAGAGTGAAGAACACAATATGTTGAGA
TGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGAAC
CTGTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACAT
GTTTATCTTCTGGAAGATGGTTTAGAATTATGGTTAGTAACTTTGGAAAACAGTCCATGT
ATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTTCA
GAAAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAA
TTTTTACAGACATACGCAGTAGGTCTATGCCAGTCCTTTTGTGAACTTTTAAAGGAAATT
ACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACCCA
ATACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAA
GGGGAGAGGTATCCTGTAGTGATGTCCACGTATCTTGGAGTTATGGGTCGAGTTCTACTA
CAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAG
ATGGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACC
CAGCCTGAAAGAAGAAAACTTTCAGCTTTGGCTTTGCTCTCTCTTCTGCCATCTGATAAT
AGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGAT
GTCATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTT
GAGGAACCAAAAGTAACAGAAGATGAAGAACCACCCACAGAACAAGATAAGAGGAAAAAG
ATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAG
CTCAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTG
GATACGGAGATTGTCACCCAGCTACAGGAGTTTTTGCAAGGATTCTAA

Protein Properties

Number of Residues

975

Molecular Weight

112534.4

Theoretical pI

4.91

Pfam Domain Function

IBN_N (PF03810 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Importin-11
MDLNSASTVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRW
LAVLYFKHGIDRYWRRVAPHALSEEEKTTLRAGLITNFNEPINQIATQIAVLIAKVARLD
CPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNF
ACSLWNHHTDTFLQEVSSGNEAAILSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLH
GIFERLKQFLECSRSIGTDNVCRDRLEKTIILFTKVLLDFLDQHPFSFTPLIQRSLEFSV
SYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAHKIKMAFFTYP
TLTEICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFHEY
NQTLTPVLLEMMQTLQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLP
ELQVIHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQDLVVRIETATTLK
LTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVG
CLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPH
VYLLEDGLELWLVTLENSPCITPELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTE
FLQTYAVGLCQSFCELLKEITTEGQVQVLKVVENALKVNPILGPQMFQPILPYVFKGIIE
GERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNIT
QPERRKLSALALLSLLPSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHL
EEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLGEQGFQSLMETV
DTEIVTQLQEFLQGF

External Links

GenBank ID Protein

39725950

UniProtKB/Swiss-Prot ID

Q9UI26

UniProtKB/Swiss-Prot Entry Name

IPO11_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_016338.4

GeneCard ID