| Identification |
|---|
| HMDB Protein ID
| CDBP03667 |
| Secondary Accession Numbers
| Not Available |
| Name
| Eukaryotic translation initiation factor 5 |
| Description
| Not Available |
| Synonyms
|
- eIF-5
|
| Gene Name
| EIF5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) |
| GO Classification
|
| Function |
| binding |
| translation initiation factor activity |
| nucleic acid binding |
| translation factor activity, nucleic acid binding |
| rna binding |
| Process |
| translational initiation |
| cellular process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q32.32 |
| SNPs
| EIF5 |
| Gene Sequence
|
>1296 bp
ATGTCTGTCAATGTCAACCGCAGCGTGTCAGACCAGTTCTATCGCTACAAGATGCCCCGT
CTGATTGCCAAGGTTGAGGGCAAAGGCAATGGAATCAAGACAGTTATAGTCAACATGGTT
GACGTTGCAAAGGCGCTTAATCGGCCTCCAACGTATCCCACCAAATATTTTGGTTGTGAG
CTGGGAGCACAGACCCAGTTTGATGTTAAGAATGACCGTTACATTGTCAATGGATCTCAT
GAGGCGAATAAGCTGCAAGACATGTTGGATGGATTCATTAAAAAATTTGTTCTCTGTCCT
GAATGTGAGAATCCTGAAACAGATTTGCATGTCAATCCAAAGAAGCAAACAATAGGTAAT
TCTTGTAAAGCCTGTGGCTATCGAGGCATGCTTGACACACATCATAAACTCTGCACATTC
ATTCTCAAAAACCCACCTGAGAATAGTGACAGTGGTACAGGAAAGAAAGAAAAAGAAAAG
AAAAACAGAAAGGGCAAAGACAAGGAAAATGGCTCCGTATCCAGCAGTGAGACACCACCA
CCACCACCACCACCAAATGAAATTAATCCTCCTCCACATACAATGGAAGAAGAGGAGGAT
GATGACTGGGGAGAAGATACAACTGAGGAAGCTCAAAGGCGTCGAATGGATGAAATCAGT
GACCATGCAAAAGTTCTGACACTCAGTGATGATTTGGAAAGAACAATTGAGGAGAGGGTC
AATATCCTCTTTGATTTTGTTAAGAAAAAGAAAGAAGAGGGTGTTATTGATTCATCTGAC
AAAGAAATCGTTGCTGAAGCAGAAAGACTGGATGTAAAAGCCATGGGCCCTCTTGTTCTA
ACTGAAGTTCTTTTTAATGAGAAGATTAGAGAACAGATTAAGAAATACAGGCGCCATTTC
CTACGATTTTGTCACAACAACAAAAAAGCCCAACGGTACCTTCTTCATGGTTTGGAGTGT
GTGGTAGCAATGCATCAAGCTCAGCTTATCTCCAAGATTCCACATATCTTGAAGGAGATG
TACGATGCAGACCTTTTAGAAGAAGAGGTCATCATCAGCTGGTCGGAAAAGGCCTCTAAG
AAATATGTCTCCAAAGAACTTGCCAAAGAGATTCGTGTCAAAGCAGAACCATTTATAAAA
TGGTTGAAGGAGGCAGAGGAAGAATCTTCTGGTGGCGAAGAAGAAGATGAAGATGAGAAC
ATTGAGGTGGTGTATTCGAAGGCTGCCAGTGTACCGAAAGTTGAGACTGTAAAGTCAGAC
AACAAGGATGACGACATCGATATTGATGCCATTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 431 |
| Molecular Weight
| 49222.4 |
| Theoretical pI
| 5.26 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Eukaryotic translation initiation factor 5
MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCE
LGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGN
SCKACGYRGMLDTHHKLCTFILKNPPENSDSGTGKKEKEKKNRKGKDKENGSVSSSETPP
PPPPPNEINPPPHTMEEEEDDDWGEDTTEEAQRRRMDEISDHAKVLTLSDDLERTIEERV
NILFDFVKKKKEEGVIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHF
LRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASK
KYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKAASVPKVETVKSD
NKDDDIDIDAI
|
| External Links |
|---|
| GenBank ID Protein
| 10439908 |
| UniProtKB/Swiss-Prot ID
| P55010 |
| UniProtKB/Swiss-Prot Entry Name
| IF5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK026933 |
| GeneCard ID
| EIF5 |
| GenAtlas ID
| EIF5 |
| HGNC ID
| HGNC:3299 |
| References |
|---|
| General References
| Not Available |