| Identification |
|---|
| HMDB Protein ID
| CDBP03663 |
| Secondary Accession Numbers
| Not Available |
| Name
| Eukaryotic translation initiation factor 2 subunit 2 |
| Description
| Not Available |
| Synonyms
|
- Eukaryotic translation initiation factor 2 subunit beta
- eIF-2-beta
|
| Gene Name
| EIF2S2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in translation initiation factor activity |
| Specific Function
| eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B |
| GO Classification
|
| Function |
| translation factor activity, nucleic acid binding |
| rna binding |
| binding |
| translation initiation factor activity |
| nucleic acid binding |
| Process |
| translational initiation |
| cellular process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20pter-q12 |
| SNPs
| EIF2S2 |
| Gene Sequence
|
>1002 bp
ATGTCTGGGGACGAGATGATTTTTGATCCTACTATGAGCAAGAAGAAAAAGAAGAAGAAG
AAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAA
ACAAAAGAAGTGGAGCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGAC
ACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTTAATCAAAAGAAA
AAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGAT
CTTAAGATTGAAAGTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATG
CTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAGGATGAAATACTA
GAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGT
AATCAGACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTG
AATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGGAGAAAAGG
AAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTC
AACTTTACAGATATCTGTAAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTG
TTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAATCAAAGGA
AGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACT
TGTCACACATGCCGATCACCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTA
CAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACCGGCTTCCAGGCT
GTCACGGGCAAGCGAGCACAGCTCCGTGCCAAAGCTAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 333 |
| Molecular Weight
| 38388.1 |
| Theoretical pI
| 5.46 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Eukaryotic translation initiation factor 2 subunit 2
MSGDEMIFDPTMSKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEED
TRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDLKIESDVQEPTEPEDDLDIM
LGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELL
NRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFL
LAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFL
QCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN
|
| External Links |
|---|
| GenBank ID Protein
| 4938295 |
| UniProtKB/Swiss-Prot ID
| P20042 |
| UniProtKB/Swiss-Prot Entry Name
| IF2B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL031668 |
| GeneCard ID
| EIF2S2 |
| GenAtlas ID
| EIF2S2 |
| HGNC ID
| HGNC:3266 |
| References |
|---|
| General References
| Not Available |