| Identification |
|---|
| HMDB Protein ID
| CDBP03662 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein-cysteine N-palmitoyltransferase HHAT |
| Description
| Not Available |
| Synonyms
|
- Hedgehog acyltransferase
- MART-2
- Melanoma antigen recognized by T-cells 2
- Skinny hedgehog protein 1
|
| Gene Name
| HHAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q32 |
| SNPs
| HHAT |
| Gene Sequence
|
>1482 bp
ATGCCGCCCCGATGGGAACTGGCACTTTACCTACTTGCCTCACTAGGCTTCCACTTCTAT
TCCTTCTATGAAGTTTACAAAGTCTCCAGAGAACACGAAGAGGAGCTGGACCAGGAATTT
GAGCTGGAGACTGACACTTTATTTGGAGGATTAAAGAAGGATGCGACCGACTTTGAGTGG
AGCTTCTGGATGGAATGGGGGAAGCAGTGGCTGGTGTGGCTTCTCCTTGGCCACATGGTA
GTGTCTCAAATGGCCACACTGCTGGCAAGAAAGCACAGACCCTGGATTCTCATGCTCTAT
GGGATGTGGGCCTGCTGGTGTGTGCTGGGGACCCCTGGTGTGGCTATGGTTTTGCTCCAT
ACCACCATCTCTTTCTGCGTGGCCCAGTTCCGGTCTCAGCTCCTGACGTGGCTCTGTTCT
CTCCTCCTCCTCTCCACACTGAGGCTGCAGGGTGTGGAAGAAGTTAAGAGAAGGTGGTAC
AAGACAGAAAACGAGTACTACCTGCTGCAGTTCACGCTGACCGTTCGCTGCCTCTACTAC
ACCAGCTTCAGCCTGGAGCTCTGCTGGCAGCAGCTGCCTGCTGCATCGACCTCCTACTCC
TTTCCCTGGATGCTGGCCTATGTCTTTTATTATCCAGTCTTACACAATGGGCCCATCCTC
AGCTTCTCGGAGTTCATCAAACAGATGCAGCAGCAGGAGCATGACTCCCTGAAGGCCAGC
CTGTGTGTCCTGGCCCTGGGGCTGGGCCGCCTTCTTTGCTGGTGGTGGCTGGCCGAGCTG
ATGGCTCACCTGATGTACATGCATGCCATCTACAGCAGCATCCCCCTCCTGGAGACTGTC
TCTTGTTGGACCTTAGGAGGACTGGCGTTAGCCCAGGTGCTCTTTTTCTACGTGAAGTAC
TTGGTGCTCTTTGGCGTGCCTGCTCTGCTCATGCGCCTGGATGGACTCACTCCACCCGCC
CTCCCCCGCTGCGTGAGCACCATGTTCAGTTTCACCGGGATGTGGAGGTATTTTGATGTT
GGACTGCATAATTTCTTAATCAGGTATGTGTACATTCCAGTGGGCGGGTCCCAGCATGGC
CTGCTGGGGACACTGTTTTCCACGGCGATGACATTTGCATTTGTGAGCTACTGGCATGGC
GGCTACGACTACCTCTGGTGCTGGGCAGCGCTCAACTGGCTGGGAGTCACTGTGGAGAAT
GGAGTCCGGAGGCTGGTGGAGACTCCCTGCATCCAGGACAGTCTGGCCCGATACTTCTCC
CCACAAGCTCGCCGTCGATTCCACGCTGCCCTTGCTTCTTGTTCCACCTCGATGCTGATC
CTGTCCAACCTGGTATTTCTTGGGGGCGATGAGGTTGGGAAAACCTACTGGAATAGGATC
TTCATACAAGGCTGGCCTTGGGTGACCCTCTCTGTCCTGGGATTCCTGTACTGCTACTCC
CACGTGGGCATTGCCTGGGCCCAGACCTACGCCACGGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 493 |
| Molecular Weight
| 57312.6 |
| Theoretical pI
| 7.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["5-25", "69-89", "95-115", "133-152", "200-220", "251-271", "290-310", "360-380", "429-449", "467-487"]
|
| Protein Sequence
|
>Protein-cysteine N-palmitoyltransferase HHAT
MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEW
SFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLH
TTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYY
TSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKAS
LCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLGGLALAQVLFFYVKY
LVLFGVPALLMRLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHG
LLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFS
PQARRRFHAALASCSTSMLILSNLVFLGGNEVGKTYWNRIFIQGWPWVTLSVLGFLYCYS
HVGIAWAQTYATD
|
| External Links |
|---|
| GenBank ID Protein
| 7022931 |
| UniProtKB/Swiss-Prot ID
| Q5VTY9 |
| UniProtKB/Swiss-Prot Entry Name
| HHAT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK001586 |
| GeneCard ID
| HHAT |
| GenAtlas ID
| HHAT |
| HGNC ID
| HGNC:18270 |
| References |
|---|
| General References
| Not Available |