| Identification |
|---|
| HMDB Protein ID
| CDBP03659 |
| Secondary Accession Numbers
| Not Available |
| Name
| PTB domain-containing engulfment adapter protein 1 |
| Description
| Not Available |
| Synonyms
|
- Cell death protein 6 homolog
- PTB domain adapter protein CED-6
- Protein GULP
|
| Gene Name
| GULP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in signal transducer activity |
| Specific Function
| May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q32.3-q33 |
| SNPs
| GULP1 |
| Gene Sequence
|
>915 bp
ATGAACCGTGCTTTTAGCAGGAAGAAAGACAAAACATGGATGCATACACCTGAAGCTTTA
TCAAAACATTTCATTCCCTATAATGCAAAGTTTCTTGGCAGTACAGAAGTGGAACAGCCA
AAAGGAACAGAAGTTGTGAGAGATGCTGTAAGGAAACTAAAGTTTGCAAGACATATCAAG
AAATCTGAAGGCCAGAAAATTCCTAAAGTGGAGTTGCAAATATCAATTTATGGAGTAAAA
ATTCTAGAACCCAAAACAAAGGAAGTTCAACACAATTGCCAGCTTCATAGAATATCTTTT
TGTGCAGATGATAAAACTGACAAGAGGATATTCACTTTCATATGCAAAGATTCTGAGTCA
AATAAACATTTGTGCTATGTATTTGACAGCGAAAAGTGTGCTGAAGAGATCACTTTAACA
ATTGGCCAAGCATTTGACCTGGCATACAGGAAATTTCTAGAATCAGGAGGAAAAGATGTT
GAAACAAGAAAACAGATCGCAGGGTTACAAAAAAGAATCCAAGACTTAGAAACAGAAAAT
ATGGAACTTAAAAATAAAGTACAAGATTTGGAAAACCAACTGAGAATAACTCAAGTATCA
GCACCTCCAGCAGGCAGTATGACACCTAAGTCGCCCTCCACTGACATCTTTGATATGATT
CCATTTTCTCCAATATCACACCAGTCTTCGATGCCTACTCGCAATGGCACACAGCCACCT
CCAGTACCTAGTAGATCTACTGAGATTAAACGGGACCTGTTTGGAGCAGAACCTTTTGAC
CCATTTAACTGTGGAGCAGCAGATTTCCCTCCAGATATTCAATCAAAATTAGATGAGATG
CAGGAGGGGTTCAAAATGGGACTAACTCTTGAAGGCACAGTATTTTGTCTCGACCCGTTA
GACAGTAGGTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 304 |
| Molecular Weight
| 34490.2 |
| Theoretical pI
| 8.0 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>PTB domain-containing engulfment adapter protein 1
MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIK
KSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSES
NKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETEN
MELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPP
PVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPL
DSRC
|
| External Links |
|---|
| GenBank ID Protein
| 7705318 |
| UniProtKB/Swiss-Prot ID
| Q9UBP9 |
| UniProtKB/Swiss-Prot Entry Name
| GULP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_016315.2 |
| GeneCard ID
| GULP1 |
| GenAtlas ID
| GULP1 |
| HGNC ID
| HGNC:18649 |
| References |
|---|
| General References
| Not Available |