| Identification |
|---|
| HMDB Protein ID
| CDBP03658 |
| Secondary Accession Numbers
| Not Available |
| Name
| Translation factor GUF1, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Elongation factor 4 homolog
- GTPase GUF1
- Ribosomal back-translocase
- EF-4
|
| Gene Name
| GUF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity).
|
| GO Classification
|
| Biological Process |
| translation |
| GTP catabolic process |
| Cellular Component |
| mitochondrial inner membrane |
| Function |
| pyrophosphatase activity |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| gtpase activity |
| nucleoside-triphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| Molecular Function |
| GTPase activity |
| GTP binding |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4p12 |
| SNPs
| GUF1 |
| Gene Sequence
|
>2010 bp
ATGTGGACCCTCGTGGGTCGGGGCTGGGGGTGCGCACGCGCTCTCGCGCCACGAGCCACT
GGGGCCGCGCTTCTGGTGGCCCCGGGGCCCCGGTCCGCGCCGACCCTTGGGGCTGCTCCA
GAGTCCTGGGCTACCGACAGGCTCTACAGCTCCGCAGAATTCAAGGAAAAACCTGACATG
TCTAGGTTTCCTGTTGAAAATATTAGAAATTTCAGTATTGTTGCACACGTGGATCATGGC
AAAAGTACTTTAACTGACAGGCTCCTAGAACTTACAGGGACAATTGATAAAACAAAGAAT
AATAAGCAGGTTCTTGATAAATTGCAAGTGGAACGAGAAAGAGGAATCACTGTTAAAGCA
CAGACAGCATCTCTCTTTTACAATTGTGAAGGAAAGCAGTACCTTTTAAATCTCATTGAT
ACACCGGGCCATGTTGATTTTAGTTATGAAGTATCCAGGTCACTTTCTGCTTGCCAGGGT
GTTTTACTTGTGGTTGATGCAAATGAGGGAATTCAAGCCCAAACTGTAGCAAACTTCTTT
CTTGCCTTCGAAGCACAGCTATCGGTAATTCCAGTTATAAATAAGATAGATCTGAAGAAT
GCTGATCCTGAAAGGGTTGAAAACCAAATTGAGAAAGTGTTTGATATTCCAAGTGATGAA
TGTATTAAGATTTCTGCTAAACTTGGAACAAATGTTGAGAGTGTTCTTCAGGCAATTATT
GAAAGAATCCCCCCTCCTAAAGTGCATCGCAAAAATCCTCTGAGAGCTTTGGTATTTGAC
TCCACCTTTGACCAGTATAGAGGTGTGATAGCCAATGTAGCATTATTTGACGGAGTGGTT
TCCAAAGGAGATAAAATTGTATCTGCACATACTCAAAAGACATACGAAGTTAATGAAGTA
GGAGTCTTGAATCCTAATGAGCAGCCAACTCATAAATTATATGCAGGACAGGTGGGCTAT
CTGATTGCTGGGATGAAAGATGTCACTGAAGCGCAAATAGGAGATACATTATGTTTACAT
AAGCAACCAGTGGAGCCCTTGCCTGGGTTTAAATCAGCGAAACCAATGGTATTTGCAGGA
ATGTATCCTCTAGACCAATCTGAATATAACAATCTGAAGAGTGCTATAGAAAAACTGACT
TTAAATGATTCCAGTGTGACCGTTCATCGGGATAGTAGCCTTGCTCTGGGTGCTGGCTGG
AGGCTAGGATTTCTTGGACTTTTGCACATGGAAGTTTTCAACCAGCGACCGGAGCAAGAA
TATAATGCTTCTGTTATTTTAACAACCCCTACTGTTCCATATAAAGCTGTACTGTCATCA
TCAAAATTGATAAAGGAACATAGAGAAAAAGAAATTACAATTATCAATCCTGCACAATTC
CCCGATAAATCAAAAGTAACAGAATATTTGGAGCCAGTTGTTTTGGGCACTATTATCACA
CCAGATGAATACACTGGAAAAATAATGATGCTTTGCGAGGCTCGAAGAGCAGTTCAGAAG
AATATGATATTTATTGATCAAAATAGAGTTATGCTTAAATATCTCTTTCCTTTGAATGAA
ATTGTGGTAGATTTTTATGACTCTTTGAAATCCCTATCTTCTGGATATGCTAGTTTTGAT
TACGAAGATGCAGGCTACCAGACTGCAGAACTTGTAAAAATGGATATTCTACTGAATGGA
AATACTGTAGAGGAGCTAGTAACTGTTGTACACAAAGACAAAGCTCATTCAATTGGCAAA
GCCATATGTGAACGGCTGAAGGATTCTCTTCCTAGGCAACTGTTTGAGATAGCAATTCAA
GCTGCTATTGGAAGTAAAATCATTGCGAGAGAAACAGTGAAAGCCTATAGGAAAAACGTT
TTGGCAAAATGTTGTGGTGGTGATATTACCCGAAAAATGAAGCTTTTGAAGAGACAAGCA
GAAGGGAAAAAAAAGCTGAGGAAAATTGGCAACGTTGAAGTTCCAAAAGATGCTTTCATA
AAAGTTCTGAAAACACAATCTTCTAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 669 |
| Molecular Weight
| 74327.2 |
| Theoretical pI
| 8.59 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>GTP-binding protein GUF1 homolog
MWTLVGRGWGCARALAPRATGAALLVAPGPRSAPTLGAAPESWATDRLYSSAEFKEKLDM
SRFPVENIRNFSIVAHVDHGKSTLADRLLELTGTIDKTKNNKQVLDKLQVERERGITVKA
QTASLFYNCEGKQYLLNLIDTPGHVDFSYEVSRSLSACQGVLLVVDANEGIQAQTVANFF
LAFEAQLSVIPVINKIDLKNADPERVENQIEKVFDIPSDECIKISAKLGTNVESVLQAII
ERIPPPKVHRKNPLRALVFDSTFDQYRGVIANVALFDGVVSKGDKIVSAHTQKTYEVNEV
GVLNPNEQPTHKLYAGQVGYLIAGMKDVTEAQIGDTLCLHKQPVEPLPGFKSAKPMVFAG
MYPLDQSEYNNLKSAIEKLTLNDSSVTVHRDSSLALGAGWRLGFLGLLHMEVFNQRLEQE
YNASVILTTPTVPYKAVLSSSKLIKEHREKEITIINPAQFPDKSKVTEYLEPVVLGTIIT
PDEYTGKIMMLCEARRAVQKNMIFIDQNRVMLKYLFPLNEIVVDFYDSLKSLSSGYASFD
YEDAGYQTAELVKMDILLNGNTVEELVTVVHKDKAHSIGKAICERLKDSLPRQLFEIAIQ
AAIGSKIIARETVKAYRKNVLAKCYGGDITRKMKLLKRQAEGKKKLRKIGNVEVPKDAFI
KVLKTQSSK
|
| External Links |
|---|
| GenBank ID Protein
| 10435150 |
| UniProtKB/Swiss-Prot ID
| Q8N442 |
| UniProtKB/Swiss-Prot Entry Name
| GUF1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK023282 |
| GeneCard ID
| GUF1 |
| GenAtlas ID
| GUF1 |
| HGNC ID
| HGNC:25799 |
| References |
|---|
| General References
| Not Available |