| Identification |
|---|
| HMDB Protein ID
| CDBP03646 |
| Secondary Accession Numbers
| Not Available |
| Name
| Guanine nucleotide-binding protein-like 3 |
| Description
| Not Available |
| Synonyms
|
- E2-induced gene 3 protein
- NNP47
- Novel nucleolar protein 47
- Nucleolar GTP-binding protein 3
- Nucleostemin
|
| Gene Name
| GNL3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
|
| Cellular Location
|
- Nucleus
- Nucleus
- nucleolus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p21.1 |
| SNPs
| GNL3 |
| Gene Sequence
|
>1650 bp
ATGAAAAGGCCTAAGTTAAAGAAAGCAAGTAAACGCATGACCTGCCATAAGCGGTATAAA
ATCCAAAAAAAGGTTCGAGAACATCATCGAAAATTAAGAAAGGAGGCTAAAAAGCGGGGT
CACAAGAAGCCTAGGAAAGACCCAGGAGTTCCAAACAGTGCTCCCTTTAAGGAGGCTCTT
CTTAGGGAAGCTGAGCTAAGGAAACAGAGGCTTGAAGAACTAAAACAGCAGCAGAAACTT
GACAGGCAGAAGGAACTAGAAAAGAAAAGAAAACTTGAAACTAATCCTGATATTAAGCCA
TCAAATGTGGAACCTATGGAAAAGGAGTTTGGGCTTTGCAAAACTGAGAACAAAGCCAAG
TCGGGCAAACAGAATTCAAAGAAGCTGTACTGCCAAGAACTTAAAAAGGTGATTGAAGCC
TCCGATGTTGTCCTAGAGGTGTTGGATGCCAGAGATCCTCTTGGTTGCAGATGTCCTCAG
GTAGAAGAGGCCATTGTCCAGAGTGGACAGAAAAAGCTGGTACTTATATTAAATAAATCA
GATCTGGTACCAAAGGAGAATTTGGAGAGCTGGCTAAATTATTTGAAGAAAGAATTGCCA
ACAGTGGTGTTCAGAGCCTCAACAAAACCAAAGGATAAAGGGAAGATAACCAAGCGTGTG
AAGGCAAAGAAGAATGCTGCTCCATTCAGAAGTGAAGTCTGCTTTGGGAAAGAGGGCCTT
TGGAAACTTCTTGGAGGTTTTCAGGAAACTTGCAGCAAAGCCATTCGGGTTGGAGTAATT
GGTTTCCCAAATGTGGGGAAAAGCAGCATTATCAATAGCTTAAAACAAGAACAGATGTGT
AATGTTGGTGTATCCATGGGGCTTACAAGGAGCATGCAAGTTGTCCCCTTGGACAAACAG
ATCACAATCATAGATAGTCCGAGCTTCATCGTATCTCCACTTAATTCCTCCTCTGCGCTT
GCTCTGCGAAGTCCAGCAAGTATTGAAGTAGTAAAACCGATGGAGGCTGCCAGTGCCATC
CTTTCCCAGGCTGATGCTCGACAGGTAGTACTGAAATATACTGTCCCAGGCTACAGGAAT
TCTCTGGAATTTTTTACTGTGCTTGCTCAGAGAAGAGGTATGCACCAAAAAGGTGGAATC
CCAAATGTTGAAGGTGCTGCCAAACTGCTGTGGTCTGAGTGGACAGGTGCCTCATTAGCT
TACTATTGCCATCCCCCTACATCTTGGACTCCTCCTCCATATTTTAATGAGAGTATTGTG
GTAGACATGAAAAGCGGCTTCAATCTGGAAGAACTGGAAAAGAACAATGCACAGAGCATA
AGAGCCATCAAGGGCCCTCATTTGGCCAATAGCATCCTTTTCCAGTCTTCCGGTCTGACA
AATGGAATAATAGAAGAAAAGGACATACATGAAGAATTGCCAAAACGGAAAGAAAGGAAG
CAGGAGGAGAGGGAGGATGACAAAGACAGTGACCAGGAAACTGTTGATGAAGAAGTTGAT
GAAAACAGCTCAGGCATGTTTGCTGCAGAAGAGACAGGGGAGGCACTGTCTGAGGAGACT
ACAGCAGGTGAACAGTCTACAAGGTCTTTTATCTTGGATAAAATCATTGAAGAGGATGAT
GCTTATGACTTCAGTACAGATTATGTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 549 |
| Molecular Weight
| 61992.7 |
| Theoretical pI
| 9.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Guanine nucleotide-binding protein-like 3
MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEAL
LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAK
SGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS
DLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL
WKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQ
ITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRN
SLEFFTVLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIV
VDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERK
QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGEQSTRSFILDKIIEEDD
AYDFSTDYV
|
| External Links |
|---|
| GenBank ID Protein
| 45593130 |
| UniProtKB/Swiss-Prot ID
| Q9BVP2 |
| UniProtKB/Swiss-Prot Entry Name
| GNL3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014366.4 |
| GeneCard ID
| GNL3 |
| GenAtlas ID
| GNL3 |
| HGNC ID
| HGNC:29931 |
| References |
|---|
| General References
| Not Available |