| Identification |
|---|
| HMDB Protein ID
| CDBP03635 |
| Secondary Accession Numbers
| Not Available |
| Name
| ADP-ribosylation factor-binding protein GGA2 |
| Description
| Not Available |
| Synonyms
|
- Gamma-adaptin-related protein 2
- Golgi-localized, gamma ear-containing, ARF-binding protein 2
- VHS domain and ear domain of gamma-adaptin
- Vear
|
| Gene Name
| GGA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif |
| GO Classification
|
| Component |
| intracellular part |
| macromolecular complex |
| protein complex |
| cytoplasmic part |
| ap-type membrane coat adaptor complex |
| intracellular |
| clathrin adaptor complex |
| membrane coat |
| golgi apparatus part |
| cell part |
| Function |
| binding |
| protein binding |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
| vesicle-mediated transport |
|
| Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Endosome membrane
- Golgi apparatus
- trans-Golgi network membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p12 |
| SNPs
| GGA2 |
| Gene Sequence
|
>1842 bp
ATGGCGGCGACCGCGGTGGCGGCGGCTGTGGCGGGAACCGAGTCGGCCCAGGGTCCCCCG
GGCCCGGCAGCGTCGCTGGAGCTGTGGCTCAACAAAGCCACAGACCCAAGCATGTCGGAA
CAGGATTGGTCAGCTATCCAGAATTTCTGTGAGCAGGTGAACACTGACCCCAATGGCCCC
ACACATGCGCCCTGGCTACTGGCCCACAAGATCCAGTCTCCGCAAGAGAAGGAAGCTCTT
TATGCCTTAACGGTGCTGGAGATGTGCATGAACCACTGTGGGGAGAAGTTCCACAGCGAG
GTGGCCAAATTTCGTTTCCTGAACGAACTGATCAAAGTGTTGTCCCCAAAGTACCTGGGG
TCCTGGGCCACAGGAAAAGTTAAAGGAAGAGTCATTGAAATACTCTTCAGTTGGACAGTC
TGGTTTCCGGAAGACATCAAGATTCGAGACGCTTATCAGATGCTGAAGAAACAAGGAATT
ATAAAACAAGACCCTAAACTACCAGTGGATAAAATCTTACCCCCACCATCTCCCTGGCCC
AAGAGCTCCATCTTTGATGCTGATGAAGAAAAGTCCAAGCTTCTGACAAGGCTTCTAAAG
AGCAACCACCCCGAGGACCTTCAGGCTGCAAACCGGTTAATCAAGAATTTGGTCAAGGAG
GAACAAGAAAAATCGGAGAAGGTGTCCAAGAGGGTCAGTGCGGTGGAGGAAGTGCGAAGC
CATGTGAAGGTGCTGCAGGAGATGCTGAGCATGTACCGCAGGCCAGGGCAGGCCCCGCCC
GACCAGGAGGCCCTGCAGGTCGTGTATGAGAGGTGTGAAAAGCTGCGGCCCACGCTGTTC
CGGTTGGCGAGTGACACCACTGATGACGATGATGCACTCGCGGAAATTCTCCAGGCAAAT
GACCTCCTCACCCAAGGAGTTCTGCTGTACAAACAGGTGATGGAGGGCCGGGTCACCTTT
GGAAACAGAGTGACCAGCTCATTGGGAGACATCCCTGTCTCCAGAGTCTTTCAGAATCCA
GCAGGCTGCATGAAGACCTGCCCCCTGATTGACTTGGAGGTGGACAATGGACCTGCGCAG
ATGGGGACTGTGGTGCCATCTTTGCTTCATCAGGACCTGGCAGCCTTGGGAATCAGTGAT
GCTCCTGTTACAGGCATGGTTTCTGGTCAGAATTGCTGTGAGGAAAAGAGGAATCCCTCC
TCCAGCACGCTGCCAGGCGGTGGTGTTCAGAACCCTTCTGCAGACAGGAATTTGCTGGAC
CTCCTCTCAGCACAGCCAGCTCCGTGCCCTCTGAATTATGTTTCGCAGAAAAGTGTCCCC
AAGGAAGTGCCACCAGGTACTAAGTCCTCTCCAGGTTGGTCCTGGGAGGCTGGCCCGTTG
GCTCCTTCCCCATCTTCACAGAATACACCTCTGGCTCAAGTGTTTGTCCCTTTGGAGTCT
GTTAAGCCCAGCAGCCTGCCGCCTCTCATTGTGTATGACCGGAATGGATTCAGAATTCTG
CTCCACTTCTCCCAGACGGGAGCCCCTGGGCACCCAGAGGTACAGGTGCTGCTCTTGACC
ATGATGAGCACGGCTCCCCAGCCTGTCTGGGATATCATGTTTCAAGTGGCTGTGCCAAAG
TCAATGAGAGTGAAGCTGCAGCCGGCATCCAGCTCCAAGCTTCCTGCATTCAGTCCTTTG
ATGCCTCCAGCTGTGATATCTCAGATGCTGCTGCTTGACAATCCACACAAAGAACCTATC
CGCTTACGGTACAAGCTGACATTCAACCAAGGTGGACAGCCTTTCAGCGAAGTAGGAGAA
GTGAAAGACTTCCCAGACCTGGCTGTCTTGGGCGCAGCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 613 |
| Molecular Weight
| 67149.7 |
| Theoretical pI
| 6.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>ADP-ribosylation factor-binding protein GGA2
MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGP
THAPWLLAHKIQSPQEKEALYALTVLEMCMNHCGEKFHSEVAKFRFLNELIKVLSPKYLG
SWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPVDKILPPPSPWP
KSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSKRVSAVEEVRS
HVKVLQEMLSMYRRPGQAPPDQEALQVVYERCEKLRPTLFRLASDTTDDDDALAEILQAN
DLLTQGVLLYKQVMEGRVTFGNRVTSSLGDIPVSRVFQNPAGCMKTCPLIDLEVDNGPAQ
MGTVVPSLLHQDLAALGISDAPVTGMVSGQNCCEEKRNPSSSTLPGGGVQNPSADRNLLD
LLSAQPAPCPLNYVSQKSVPKEVPPGTKSSPGWSWEAGPLAPSPSSQNTPLAQVFVPLES
VKPSSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLLTMMSTAPQPVWDIMFQVAVPK
SMRVKLQPASSSKLPAFSPLMPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGE
VKDFPDLAVLGAA
|
| External Links |
|---|
| GenBank ID Protein
| 9558751 |
| UniProtKB/Swiss-Prot ID
| Q9UJY4 |
| UniProtKB/Swiss-Prot Entry Name
| GGA2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_015044.4 |
| GeneCard ID
| GGA2 |
| GenAtlas ID
| GGA2 |
| HGNC ID
| HGNC:16064 |
| References |
|---|
| General References
| Not Available |