Cannabis Compound Database: Showing Protein Guanylate-binding protein 4 (CDBP03631)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03631

Secondary Accession Numbers

Not Available

Name

Guanylate-binding protein 4

Description

Not Available

Synonyms

GBP-4
GTP-binding protein 4
Guanine nucleotide-binding protein 4

Gene Name

GBP4

Protein Type

Enzyme

Biological Properties

General Function

Involved in GTPase activity

Specific Function

Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation

GO Classification

Function
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity

Cellular Location

Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1p22.2

SNPs

GBP4

Gene Sequence

>1923 bp
ATGGGTGAGAGAACTCTTCACGCTGCAGTGCCCACACCAGGTTATCCAGAATCTGAATCC
ATCATGATGGCCCCCATTTGTCTAGTGGAAAACCAGGAAGAGCAGCTGACAGTGAATTCA
AAGGCATTAGAGATTCTTGACAAGATTTCTCAGCCCGTGGTGGTGGTGGCCATTGTAGGG
CTATACCGCACAGGAAAATCCTATCTCATGAATCGTCTTGCAGGAAAGCGCAATGGCTTC
CCTCTGGGCTCCACGGTGCAGTCTGAAACTAAGGGCATCTGGATGTGGTGTGTGCCCCAC
CTCTCTAAGCCAAACCACACCCTGGTCCTTCTGGACACCGAGGGCCTGGGCGATGTAGAA
AAGAGTAACCCTAAGAATGACTCGTGGATCTTTGCCCTGGCTGTGCTTCTAAGCAGCAGC
TTTGTCTATAACAGCGTGAGCACCATCAACCACCAGGCCCTGGAGCAGCTGCACTATGTG
ACTGAGCTAGCAGAGCTAATCAGGGCAAAATCCTGCCCCAGACCTGATGAAGCTGAGGAC
TCCAGCGAGTTTGCGAGTTTCTTTCCAGACTTTATTTGGACTGTTCGGGATTTTACCCTG
GAGCTAAAGTTAGATGGAAACCCCATCACAGAAGATGAGTACCTGGAGAATGCCTTGAAG
CTGATTCCAGGCAAGAATCCCAAAATTCAAAATTCAAACATGCCTAGAGAGTGTATCAGG
CATTTCTTCCGAAAACGGAAGTGCTTTGTCTTTGACCGGCCTACAAATGACAAGCAATAT
TTAAATCATATGGACGAAGTGCCAGAAGAAAATCTGGAAAGGCATTTCCTTATGCAATCA
GACAACTTCTGTTCTTATATCTTCACCCATGCAAAGACCAAGACCCTGAGAGAGGGAATC
ATTGTCACTGGAAAGCGGCTGGGGACTCTGGTGGTGACTTATGTAGATGCCATCAACAGT
GGAGCAGTACCTTGTCTGGAGAATGCAGTGACAGCACTGGCCCAGCTTGAGAACCCAGCG
GCTGTGCAGAGGGCAGCCGACCACTATAGCCAGCAGATGGCCCAGCAACTGAGGCTCCCC
ACAGACACGCTCCAGGAGCTGCTGGACGTGCATGCAGCCTGTGAGAGGGAAGCCATTGCA
GTCTTCATGGAGCACTCCTTCAAGGATGAAAACCATGAATTCCAGAAGAAGCTTGTGGAC
ACCATAGAGAAAAAGAAGGGAGACTTTGTGCTGCAGAATGAAGAGGCATCTGCCAAATAT
TGCCAGGCTGAGCTTAAGCGGCTTTCAGAGCACCTGACAGAAAGCATTTTGAGAGGAATT
TTCTCTGTTCCTGGAGGACACAATCTCTACTTAGAAGAAAAGAAACAGGTTGAGTGGGAC
TATAAGCTAGTGCCCAGAAAAGGAGTTAAGGCAAACGAGGTCCTCCAGAACTTCCTGCAG
TCACAGGTGGTTGTAGAGGAATCCATCCTGCAGTCAGACAAAGCCCTCACTGCTGGAGAG
AAGGCCATAGCAGCGGAGCGGGCCATGAAGGAAGCAGCTGAGAAGGAACAGGAGCTGCTA
AGAGAAAAACAGAAGGAGCAGCAGCAAATGATGGAGGCTCAAGAGAGAAGCTTCCAGGAA
AACATAGCTCAACTCAAGAAGAAGATGGAGAGGGAAAGGGAAAACCTTCTCAGAGAGCAT
GAAAGGCTGCTAAAACACAAGCTGAAGGTACAAGAAGAAATGCTTAAGGAAGAATTTCAA
AAGAAATCTGAGCAGTTAAATAAAGAGATTAATCAACTGAAAGAAAAAATTGAAAGCACT
AAAAATGAACAGTTAAGGCTCTTAAAGATCCTTGACATGGCTAGCAACATAATGATTGTC
ACTCTACCTGGGGCTTCCAAGCTACTTGGAGTAGGGACAAAATATCTTGGCTCACGTATT
TAA

Protein Properties

Number of Residues

640

Molecular Weight

73164.2

Theoretical pI

5.89

Pfam Domain Function

GBP (PF02263 )
GBP_C (PF02841 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Guanylate-binding protein 4
MGERTLHAAVPTPGYPESESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVG
LYRTGKSYLMNRLAGKRNGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVE
KSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAED
SSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIR
HFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGI
IVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLP
TDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKY
CQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQ
SQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQE
YMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIEST
KNEQLRLLKILDMASNIMIVTLPGASKLLGVGTKYLGSRI

External Links

GenBank ID Protein

15558943

UniProtKB/Swiss-Prot ID

Q96PP9

UniProtKB/Swiss-Prot Entry Name

GBP4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF288814

GeneCard ID