Showing Protein Interferon-induced guanylate-binding protein 2 (CDBP03629)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03629
Secondary Accession Numbers Not Available
Name Interferon-induced guanylate-binding protein 2
Description Not Available
Synonyms
  1. GBP-2
  2. GTP-binding protein 2
  3. Guanine nucleotide-binding protein 2
  4. HuGBP-2
Gene Name GBP2
Protein Type Enzyme
Biological Properties
General Function Involved in GTPase activity
Specific Function Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product
GO Classification
Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Cellular Location
  1. Cell membrane
  2. Lipid-anchor
  3. Cytoplasmic side (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1p22.2
SNPs GBP2
Gene Sequence 
>1776 bp
ATGGCTCCAGAGATCAACTTGCCGGGCCCAATGAGCCTCATTGATAACACTAAAGGGCAG
CTGGTGGTGAATCCAGAAGCTCTGAAGATCCTATCTGCAATTACGCAGCCTGTGGTGGTG
GTGGCGATTGTGGGCCTCTATCGCACAGGCAAATCCTACCTGATGAACAAGCTGGCTGGG
AAGAAAAACGGCTTCTCTCTAGGCTCCACAGTGAAGTCTCACACCAAGGGAATCTGGATG
TGGTGTGTGCCTCATCCCAAGAAGCCAGAACACACCCTAGTTCTGCTCGACACTGAGGGC
CTGGGAGATATAGAGAAGGGTGACAATGAGAATGACTCCTGGATCTTTGCCTTGGCCATC
CTCCTGAGCAGCACCTTCGTGTACAATAGCATGGGAACCATCAACCAGCAGGCCATGGAC
CAACTTCACTATGTGACAGAGCTGACAGATCGAATCAAGGCAAACTCCTCACCTGGTAAC
AATTCTGTAGACGACTCAGCTGACTTTGTGAGCTTTTTTCCAGCATTTGTGTGGACTCTC
AGAGATTTCACCCTGGAACTGGAAGTAGATGGAGAACCCATCACTGCTGATGACTACTTG
GAGCTTTCGCTAAAGCTAAGAAAAGGTACTGATAAGAAAAGTAAAAGCTTTAATGATCCT
CGGTTGTGCATCCGAAAGTTCTTCCCCAAGAGGAAGTGCTTCGTCTTCGATTGGCCCGCT
CCTAAGAAGTACCTTGCTCACCTAGAGCAGCTAAAGGAGGAAGAGCTGAACCCTGATTTC
ATAGAACAAGTTGCAGAATTTTGTTCCTACATCCTCAGCCATTCCAATGTCAAGACTCTT
TCAGGTGGCATTCCAGTCAATGGGCCTCGTCTAGAGAGCCTGGTGCTGACCTACGTCAAT
GCCATCAGCAGTGGGGATCTACCCTGCATGGAGAACGCAGTCCTGGCCTTGGCCCAGATA
GAGAACTCAGCCGCAGTGGAAAAGGCTATTGCCCACTATGAACAGCAGATGGGCCAGAAG
GTGCAGCTGCCCACGGAAACCCTCCAGGAGCTGCTGGACCTGCACAGGGACAGTGAGAGA
GAGGCCATTGAAGTCTTCATGAAGAACTCTTTCAAGGATGTGGACCAAATGTTCCAGAGG
AAATTAGGGGCCCAGTTGGAAGCAAGGCGAGATGACTTTTGTAAGCAGAATTCCAAAGCA
TCATCAGATTGTTGCATGGCTTTACTTCAGGATATATTTGGCCCTTTAGAAGAAGATGTC
AAGCAGGGAACATTTTCTAAACCAGGAGGTTACCGTCTCTTTACTCAGAAGCTGCAGGAG
CTGAAGAATAAGTACTACCAGGTGCCAAGGAAGGGGATACAGGCCAAAGAGGTGCTGAAA
AAATATTTGGAGTCCAAGGAGGATGTGGCTGATGCACTTCTACAGACTGATCAGTCACTC
TCAGAAAAGGAAAAAGCGATTGAAGTGGAACGTATAAAGGCTGAATCTGCAGAAGCTGCA
AAGAAAATGTTGGAGGAAATACAAAAGAAGAATGAGGAGATGATGGAACAGAAAGAGAAG
AGTTATCAGGAACATGTGAAACAATTGACTGAGAAGATGGAGAGGGACAGGGCCCAGTTA
ATGGCAGAGCAAGAGAAGACCCTCGCTCTTAAACTTCAGGAACAGGAACGCCTTCTCAAG
GAGGGATTCGAGAATGAGAGCAAGAGACTTCAAAAAGACATATGGGATATCCAGATGAGA
AGCAAATCATTGGAGCCAATATGTAACATACTCTAA
Protein Properties
Number of Residues 591
Molecular Weight 67208.5
Theoretical pI 5.41
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Interferon-induced guanylate-binding protein 2
MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI
LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL
RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA
PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVN
AISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSER
EAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDV
KQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSL
SEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQL
MAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL
GenBank ID Protein 38327558
UniProtKB/Swiss-Prot ID P32456
UniProtKB/Swiss-Prot Entry Name GBP2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_004120.3
GeneCard ID GBP2
GenAtlas ID GBP2
HGNC ID HGNC:4183
References
General References Not Available