| Identification |
|---|
| HMDB Protein ID
| CDBP03609 |
| Secondary Accession Numbers
| Not Available |
| Name
| FYVE, RhoGEF and PH domain-containing protein 6 |
| Description
| Not Available |
| Synonyms
|
- Zinc finger FYVE domain-containing protein 24
|
| Gene Name
| FGD6 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| rho guanyl-nucleotide exchange factor activity |
| transition metal ion binding |
| zinc ion binding |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| small gtpase regulator activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| ras guanyl-nucleotide exchange factor activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm (Probable)
- cytoskeleton (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q22 |
| SNPs
| FGD6 |
| Gene Sequence
|
>4293 bp
ATGACTTCTGCAGCCGAGATAAAGAAGCCACCAGTGGCCCCCAAGCCCAAGTTTGTTGTG
GCAAATAATAAGCCAGCCCCACCTCCTATTGCACCTAAACCCGACATTGTGATTTCTAGT
GTTCCACAGTCGACAAAGAAAATGAAACCAGCAATAGCCCCAAAACCAAAAGTCCTGAAG
ACCTCACCTGTTCGAGAGATTGGGCAGTCGCCATCAAGGAAAATCATGTTGAACCTGGAA
GGGCATAAACAGGAATTAGCTGAAAGCACTGACAACTTTAATTGTAAATATGAAGGCAAT
CAGAGCAATGATTATATTTCACCAATGTGTTCCTGCAGTTCTGAGTGTATCCATAAGCTG
GGCCATAGAGAGAATTTGTGTGTAAAGCAGCTTGTTTTAGAGCCCCTGGAAATGAATGAA
AATTTAGAAAACAGTAAAATTGATGAGACTTTGACTATAAAAACTAGGAGTAAATGTGAT
TTGTATGGTGAAAAAGCCAAGAACCAGGGTGGGGTTGTTTTAAAGGCAAGCGTTTTAGAA
GAGGAGCTCAAAGATGCCTTAATACACCAAATGCCACCTTTTATTTCTGCACAGAAGCAC
AGGCCCACAGACAGCCCAGAAATGAATGGTGGCTGTAATTCAAATGGACAATTCAGAATT
GAATTTGCGGATTTGTCACCTTCCCCATCCAGCTTTGAAAAAGTTCCTGATCATCACAGT
TGCCACTTACAGCTTCCTAGTGATGAATGTGAACATTTTGAAACTTGCCAGGATGACAGT
GAAAAAAGCAATAATTGCTTTCAGTCATCTGAACTAGAGGCTCTGGAAAATGGGAAAAGG
AGTACTTTAATATCTTCAGATGGAGTTAGTAAGAAATCAGAAGTCAAAGACCTTGGTCCC
TTAGAAATTCATTTAGTACCATATACCCCAAAATTTCCAACTCCCAAGCCCAGAAAGACA
CGAACTGCTCGTCTGTTACGCCAAAAGTGTGTAGATACTCCTAGTGAAAGCACTGAAGAA
CCGGGGAATTCAGACAGTAGCTCTTCCTGTCTTACTGAAAATAGTTTGAAAATCAATAAA
ATCAGTGTTCTGCATCAGAATGTTTTGTGTAAGCAGGAACAGGTGGATAAAATGAAGCTA
GGAAATAAAAGTGAATTGAATATGGAATCCAACAGTGATGCACAGGACTTAGTCAATTCA
CAGAAAGCCATGTGTAATGAAACAACTTCCTTTGAAAAAATGGCACCTTCTTTTGATAAA
GACTCTAATTTGAGTTCTGACAGCACAACTGTAGATGGTTCTAGTATGTCGCTTGCTGTG
GACGAAGGGACCGGTTTTATAAGATGTACTGTATCTATGAGCCTGCCTAAGCAGCTCAAA
TTAACTTGCAATGAACATTTGCAATCTGGGAGAAACCTGGGAGTTTCTGCCCCTCAAATG
CAAAAGGAATCTGTTATAAAAGAGGAAAATTCTCTACGAATTGTCCCCAAAAAACCTCAA
AGACATAGCTTGCCTGCTACAGGAGTGCTTAAAAAGGCTGCCTCCGAGGAGCTTTTGGAA
AAAAGTTCTTATCCTTCAAGTGAAGAAAAAAGTTCAGAGAAGAGTCTAGAAAGAAATCAC
CTTCAGCATTTGTGTGCCCAAAACCGTGGTGTGTCATCCTCCTTTGATATGCCTAAACGG
GCTTCAGAAAAGCCAGTGTGGAAGTTACCTCATCCTATTTTACCCTTTTCAGGGAACCCA
GAATTCTTAAAGTCTGTCACCGTATCGTCAAACAGTGAGCCTTCAACAGCCCTAACCAAG
CCCAGAGCAAAATCGTTATCTGCTATGGATGTGGAAAAGTGCACTAAGCCTTGCAAAGAC
TCTACAAAGAAAAACTCTTTTAAAAAGTTGCTCAGCATGAAACTGTCCATCTGTTTCATG
AAGAGTGACTTTCAAAAATTTTGGTCCAAGAGTAGCCAACTCGGAGACACCACCACAGGC
CACCTCTCCAGTGGGGAGCAGAAGGGGATTGAAAGTGATTGGCAAGGCTTGTTGGTAGGA
GAGGAGAAGAGAAGTAAACCCATCAAGGCATATTCCACAGAAAACTATAGCCTGGAATCT
CAAAAGAAGAGGAAGAAGTCTCGGGGCCAGACCAGTGCAGCTAATGGTCTGAGAGCTGAG
TCTTTGGATGACCAAATGCTCTCCCGGGAGTCATCATCTCAGGCACCTTACAAGTCTGTT
ACAAGCCTCTGTGCACCGGAGTATGAAAATATACGCCATTATGAGGAAATACCAGAGTAC
GAGAACTTGCCATTTATTATGGCTATACGGAAAACTCAAGAGTTGGAATGGCAGAATTCC
AGCAGCATGGAGGACGCTGATGCAAATGTGTATGAGGTAGAAGAGCCGTATGAAGCTCCA
GATGGCCAGCTGCAGCTTGGACCCAGACATCAGCATTCCAGTTCAGGAGCATCCCAGGAG
GAACAGAATGATCTTGGTCTTGGTGACCTTCCCTCTGATGAGGAGGAAATCATCAACAGT
TCTGATGAAGATGATGTCAGCTCTGAGTCAAGTAAAGGAGAGCCTGACCCACTGGAAGAT
AAACAGGATGAAGATAATGGAATGAAAAGTAAAGTTCATCATATTGCCAAGGAGATCATG
AGCTCAGAGAAAGTGTTTGTGGATGTGTTAAAACTTTTGCATATTGATTTCCGGGATGCA
GTAGCTCATGCTTCCAGGCAACTTGGGAAACCAGTGATTGAGGACCGGATTCTAAATCAG
ATCCTATACTACTTGCCTCAGCTGTATGAGCTCAACCGGGATCTCTTGAAGGAACTGGAG
GAAAGAATGTTGCACTGGACTGAACAACAAAGAATTGCTGATATCTTTGTAAAGAAGGGA
CCATATCTAAAAATGTATTCCACATACATCAAAGAATTTGATAAGAATATAGCCTTGCTG
GATGAACAGTGCAAGAAAAATCCAGGTTTTGCTGCTGTTGTTAGAGAATTTGAGATGAGC
CCTCGCTGTGCTAATCTGGCCCTCAAGCACTACCTGCTCAAGCCGGTTCAGAGGATCCCC
CAGTACAGGCTGTTGCTGACAGATTATTTGAAGAATCTCATAGAAGATGCTGGAGATTAC
AGAGACACTCAAGATGCCCTTGCTGTTGTTATAGAGGTAGCCAACCACGCCAATGACACC
ATGAAGCAAGGAGACAACTTTCAGAAACTTATGCAAATTCAGTACAGCTTAAATGGACAC
CATGAAATTGTGCAGCCTGGTCGGGTTTTTCTCAAAGAAGGAATTCTGATGAAGCTGTCT
CGGAAAGTGATGCAACCTCGAATGTTTTTCCTGTTTAATGATGCCCTGCTGTATACAACA
CCAGTGCAGTCTGGGATGTATAAACTGAACAACATGCTCTCACTGGCTGGAATGAAGGTC
AGAAAACCTACCCAAGAAGCCTATCAGAATGAATTAAAGATTGAAAGTGTAGAACGTTCC
TTCATTCTCTCAGCCAGTTCTGCCACAGAAAGGGATGAATGGCTAGAAGCGATTTCCAGG
GCAATAGAAGAGTATGCCAAGAAAAGAATCACCTTCTGTCCTAGTAGGAGTCTTGATGAG
GCAGACTCAGAAAATAAAGAAGAAGTTAGTCCTCTTGGATCGAAGGCTCCCATCTGGATT
CCTGATACCAGAGCCACAATGTGTATGATCTGCACAAGCGAATTCACTCTCACCTGGAGA
CGACACCACTGCCGGGCCTGTGGAAAGATTGTATGCCAAGCTTGTTCGTCTAATAAGTAT
GGCTTAGATTACCTGAAAAATCAACCAGCAAGAGTATGTGAACATTGTTTCCAAGAACTG
CAGAAATTAGATCACCAGCACTCCCCTAGGATTGGATCTCCTGGAAATCACAAATCTCCT
TCAAGTGCCTTATCATCAGTCTTACATAGCATTCCATCAGGGAGGAAACAGAAAAAAATC
CCAGCTGCTCTCAAAGAAGTATCAGCAAACACAGAGGATTCTTCTATGAGTGGCTACTTG
TACAGATCAAAGGGCAATAAAAAACCCTGGAAACACTTTTGGTTTGTCATAAAAAATAAA
GTACTATATACATATGCTGCAAGTGAGGACGTGGCCGCTTTGGAGAGTCAGCCTTTATTA
GGATTCACTGTTATTCAAGTTAAAGATGAGAATTCCGAGTCTAAAGTATTTCAGTTACTG
CACAAAAACATGTTATTTTATGTATTCAAAGCAGAGGATGCTCATTCGGCTCAGAAGTGG
ATAGAAGCATTTCAGGAAGGCACAATATTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1430 |
| Molecular Weight
| 160814.9 |
| Theoretical pI
| 7.03 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>FYVE, RhoGEF and PH domain-containing protein 6
MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLK
TSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKL
GHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLE
EELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHS
CHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGP
LEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINK
ISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDK
DSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQM
QKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNH
LQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTK
PRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTG
HLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAE
SLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNS
SSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINS
SDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDA
VAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKG
PYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIP
QYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGH
HEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKV
RKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDE
ADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKY
GLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKI
PAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLL
GFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL
|
| External Links |
|---|
| GenBank ID Protein
| 154240686 |
| UniProtKB/Swiss-Prot ID
| Q6ZV73 |
| UniProtKB/Swiss-Prot Entry Name
| FGD6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018351.3 |
| GeneCard ID
| FGD6 |
| GenAtlas ID
| FGD6 |
| HGNC ID
| HGNC:21740 |
| References |
|---|
| General References
| Not Available |