Showing Protein FYVE, RhoGEF and PH domain-containing protein 1 (CDBP03604)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03604
Secondary Accession Numbers Not Available
Name FYVE, RhoGEF and PH domain-containing protein 1
Description Not Available
Synonyms
  1. Faciogenital dysplasia 1 protein
  2. Rho/Rac GEF
  3. Rho/Rac guanine nucleotide exchange factor FGD1
  4. Zinc finger FYVE domain-containing protein 3
Gene Name FGD1
Protein Type Metal Binding
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape
GO Classification
Component
cell part
intracellular
Function
nucleoside-triphosphatase regulator activity
gtpase regulator activity
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
transition metal ion binding
zinc ion binding
enzyme regulator activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location
  1. Cytoplasm
  2. Cytoplasm
  3. cytoskeleton
  4. Cell projection
  5. Cell projection
  6. lamellipodium
  7. ruffle
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs FGD1
Gene Sequence 
>2886 bp
ATGCATGGCCACCGAGCCCCGGGGGGCGCCGGGCCTTCGGAGCCCGAACACCCGGCCACG
AACCCGCCGGGCGCCGCTCCGCCGGCCTGTGCCGACTCGGACCCTGGAGCCTCGGAACCC
GGACTGCTGGCGCGCAGGGGCTCAGGTTCGGCTCTTGGCGGCCCACTGGATCCCCAGTTT
GTCGGACCCTCGGACACCAGCCTGGGCGCTGCTCCAGGCCACCGGGTCTTGCCCTGCGGT
CCCAGTCCACAGCACCACCGGGCCCTGCGCTTCTCTTACCACCTGGAGGGCTCGCAGCCT
CGGCCTGGGCTGCACCAGGGAAACCGGATCCTGGTTAAAAGTTTGTCCCTTGACCCTGGC
CAAAGCCTAGAGCCTCATCCAGAAGGTCCCCAGCGGCTTCGCTCAGACCCAGGTCCCCCG
ACTGAAACCCCTAGCCAGCGTCCTTCACCACTGAAGCGGGCACCGGGCCCGAAGCCACAG
GTGCCCCCAAAGCCCAGCTACCTGCAGATGCCCCGGATGCCCCCCCCACTGGAGCCCATC
CCCCCTCCACCATCACGCCCACTGCCTGCCGACCCCCGAGTGGCCAAGGGCCTGGCTCCC
AGGGCAGAGGCCAGCCCCAGTTCTGCAGCAGTATCCTCACTGATTGAGAAGTTTGAAAGA
GAGCCTGTGATTGTCGCCTCGGATAGACCAGTCCCTGGCCCCAGCCCAGGTCCCCCAGAG
CCAGTCATGTTGCCACAGCCAACCTCGCAGCCACCAGTGCCCCAGCTCCCCGAGGGTGAG
GCCTCCCGCTGCCTGTTTCTGCTGGCTCCTGGGCCCCGGGACGGTGAGAAGGTGCCCAAC
CGGGACAGCGGCATTGATAGCATCAGCTCGCCATCCAACAGCGAGGAGACCTGCTTCGTC
AGTGATGACGGGCCCCCCAGCCACAGCCTCTGCCCTGGGCCCCCTGCCCTGGCTAGTGTG
CCTGTTGCCTTGGCCGACCCCCACCGGCCTGGCTCCCAAGAGGTTGACAGTGACCTGGAG
GAGGAGGACGACGAGGAGGAGGAGGAAGAGAAGGACAGAGAAATCCCAGTGCCCCTGATG
GAGAGACAGGAGTCTGTGGAGTTGACTGTGCAGCAAAAGGTGTTTCACATTGCCAATGAG
CTCCTGCAAACTGAGAAGGCCTACGTTTCCAGGCTCCATCTCCTGGATCAGGTGTTCTGT
GCCCGGCTGCTGGAAGAAGCTCGGAACCGCAGTTCCTTCCCGGCCGACGTTGTCCACGGC
ATCTTCTCTAACATCTGCTCCATCTATTGCTTCCACCAGCAGTTCCTGCTGCCTGAGCTA
GAGAAGCGCATGGAGGAATGGGACCGCTATCCACGCATTGGAGACATCCTGCAGAAACTG
GCCCCCTTCCTCAAGATGTATGGTGAGTATGTGAAGAACTTTGACCGGGCCGTGGAGCTG
GTCAACACCTGGACAGAGCGCTCCACCCAGTTTAAAGTCATCATCCATGAGGTGCAGAAG
GAGGAAGCCTGTGGCAACCTGACATTGCAGCACCACATGCTGGAGCCTGTGCAGCGCATC
CCCCGCTATGAGCTTCTTCTCAAGGACTATCTGTTAAAGCTGCCCCATGGCTCCCCGGAC
AGCAAGGATGCCCAAAAGTCTCTGGAGCTGATCGCCACAGCAGCAGAGCACTCGAATGCT
GCCATCCGCAAAATGGAGCGAATGCATAAGCTGCTGAAGGTATATGAGCTGTTAGGGGGC
GAGGAGGACATTGTCAGCCCCACCAAAGAGCTCATAAAAGAAGGCCACATCCTTAAGCTG
TCAGCAAAGAATGGGACCACTCAAGACCGATACCTCATACTATTCAACGACCGCCTCCTT
TACTGCGTGCCCAGGCTGCGGCTCCTTGGCCAGAAGTTTAGCGTGCGGGCACGCATTGAT
GTAGATGGCATGGAGCTAAAGGAGAGCTCCAACCTCAATCTGCCTCGAACCTTCCTGGTG
TCAGGAAAGCAGCGCTCCCTCGAGCTCCAGGCCAGGACTGAGGAGGAGAAGAAAGACTGG
GTCCAGGCCATCAACTCCACCCTCCTGAAGCATGAACAGACGCTGGAGACTTTCAAACTG
TTGAACTCAACAAACAGGGAAGATGAAGACACCCCACCCAACTCTCCAAACGTGGATCTT
GGGAAGCGGGCACCTACGCCCATCCGGGAAAAGGAAGTCACCATGTGCATGCGCTGCCAG
GAGCCCTTCAATTCTATCACCAAACGCAGGCACCACTGCAAGGCCTGCGGGCATGTGGTT
TGTGGGAAGTGCTCCGAGTTCCGGGCCCGCCTCGTCTATGACAACAACCGCTCCAACCGT
GTGTGCACTGATTGCTATGTGGCCTTGCACGGGGTGCCTGGGAGCAGTCCAGCCTGCAGC
CAGCATACACCCCAGCGCCGGAGGTCCATCCTGGAGAAACAGGCCTCAGTGGCTGCAGAG
AACAGCGTCATCTGCAGCTTCCTGCACTACATGGAGAAGGGTGGCAAAGGATGGCACAAG
GCATGGTTCGTGGTCCCTGAAAATGAACCCTTGGTGCTGTATATCTACGGAGCCCCTCAG
GATGTGAAAGCCCAGCGCAGCCTGCCCCTCATTGGCTTCGAGGTGGGACCGCCCGAGGCA
GGGGAGCGGCCTGACAGAAGGCATGTCTTCAAGATCACCCAGAGCCACCTCAGCTGGTAC
TTCAGCCCTGAGACAGAGGAACTACAGCGACGCTGGATGGCTGTGCTTGGCCGGGCGGGC
CGAGGGGACACGTTCTGCCCGGGGCCCACACTGTCTGAGGACAGGGAGATGGAGGAGGCA
CCGGTGGCTGCTTTAGGAGCCACTGCTGAACCCCCCGAATCCCCCCAGACCCGAGACAAG
ACCTAG
Protein Properties
Number of Residues 961
Molecular Weight 106559.9
Theoretical pI 6.56
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>FYVE, RhoGEF and PH domain-containing protein 1
MHGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQF
VGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPG
QSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPI
PPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPE
PVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFV
SDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLM
ERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHG
IFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVEL
VNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPD
SKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKL
SAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLV
SGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDL
GKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNR
VCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHK
AWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWY
FSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDK
T
GenBank ID Protein 21961608
UniProtKB/Swiss-Prot ID P98174
UniProtKB/Swiss-Prot Entry Name FGD1_HUMAN
PDB IDs Not Available
GenBank Gene ID BC034530
GeneCard ID FGD1
GenAtlas ID FGD1
HGNC ID HGNC:3663
References
General References Not Available