| Identification |
|---|
| HMDB Protein ID
| CDBP03603 |
| Secondary Accession Numbers
| Not Available |
| Name
| F-box only protein 8 |
| Description
| Not Available |
| Synonyms
|
- F-box/SEC7 protein FBS
|
| Gene Name
| FBXO8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ARF guanyl-nucleotide exchange factor activity |
| Specific Function
| May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential) |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| enzyme regulator activity |
| arf guanyl-nucleotide exchange factor activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
| regulation of ras protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of arf protein signal transduction |
| regulation of cellular process |
| regulation of cell communication |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q34.1 |
| SNPs
| FBXO8 |
| Gene Sequence
|
>960 bp
ATGGGTCAAGGGTTGTGGAGAGTGGTCAGAAACCAGCAGCTGCAACAAGAAGGCTACAGT
GAGCAAGGCTACCTCACCAGAGAGCAGAGCAGGAGAATGGCTGCGAGCAACATTTCTAAC
ACCAATCATCGTAAACAAGTCCAAGGAGGCATTGACATATATCATCTTTTGAAGGCAAGG
AAATCGAAAGAACAGGAAGGATTCATTAATTTGGAAATGTTGCCTCCTGAGCTAAGCTTT
ACCATCTTGTCCTACCTGAATGCAACTGACCTTTGCTTGGCTTCATGTGTTTGGCAGGAC
CTTGCGAATGATGAACTTCTCTGGCAAGGGTTGTGCAAATCCACTTGGGGTCACTGTTCC
ATATACAATAAGAACCCACCTTTAGGATTTTCTTTTAGAAAATTGTATATGCAGCTGGAT
GAAGGCAGCCTCACCTTTAATGCCAACCCAGATGAGGGAGTGAACTACTTTATGTCCAAG
GGTATCCTGGATGATTCGCCAAAGGAAATAGCAAAGTTTATCTTCTGTACAAGAACACTA
AATTGGAAAAAACTGAGAATCTATCTTGATGAAAGGAGAGATGTCTTGGATGACCTTGTA
ACATTGCATAATTTTAGAAATCAGTTCTTGCCAAATGCACTGAGAGAATTTTTTCGTCAT
ATCCATGCCCCTGAAGAGCGTGGAGAGTATCTTGAAACTCTTATAACAAAGTTCTCACAT
AGATTCTGTGCTTGCAACCCTGATTTAATGCGAGAACTTGGCCTTAGTCCTGATGCTGTC
TATGTACTGTGCTACTCTTTGATTCTACTTTCCATTGACCTCACTAGCCCTCATGTGAAG
AATAAAATGTCAAAAAGGGAATTTATTCGAAATACCCGTCGCGCTGCTCAAAATATTAGT
GAAGATTTTGTAGGGCATCTTTATGACAATATCTACCTTATTGGCCATGTGGCTGCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 319 |
| Molecular Weight
| 37068.0 |
| Theoretical pI
| 7.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>F-box only protein 8
MGQGLWRVVRNQQLQQEGYSEQGYLTREQSRRMAASNISNTNHRKQVQGGIDIYHLLKAR
KSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCS
IYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTL
NWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSH
RFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNIS
EDFVGHLYDNIYLIGHVAA
|
| External Links |
|---|
| GenBank ID Protein
| 48928044 |
| UniProtKB/Swiss-Prot ID
| Q9NRD0 |
| UniProtKB/Swiss-Prot Entry Name
| FBX8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_012180.2 |
| GeneCard ID
| FBXO8 |
| GenAtlas ID
| FBXO8 |
| HGNC ID
| HGNC:13587 |
| References |
|---|
| General References
| Not Available |