| Identification |
|---|
| HMDB Protein ID
| CDBP03602 |
| Secondary Accession Numbers
| Not Available |
| Name
| Formin-binding protein 1-like |
| Description
| Not Available |
| Synonyms
|
- Toca-1
- Transducer of Cdc42-dependent actin assembly protein 1
|
| Gene Name
| FNBP1L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in lipid binding |
| Specific Function
| Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Cytoplasm
- Cytoplasm
- Peripheral membrane protein
- Cytoplasmic vesicle
- Cytoplasmic side
- cytoskeleton
- cell cortex
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p22.1 |
| SNPs
| FNBP1L |
| Gene Sequence
|
>1818 bp
ATGAGCTGGGGCACGGAGCTGTGGGATCAGTTCGACAGCTTAGACAAGCATACACAATGG
GGAATTGACTTCTTGGAAAGATATGCCAAATTTGTTAAAGAGAGGATAGAAATTGAACAG
AACTATGCGAAACAATTGAGAAATCTGGTTAAGAAGTACTGCCCCAAACGTTCATCCAAA
GATGAAGAGCCACGGTTTACCTCGTGTGTAGCCTTTTTTAATATCCTTAATGAGTTAAAT
GACTATGCAGGACAGCGAGAAGTTGTAGCAGAAGAAATGGCGCACAGAGTGTATGGTGAA
TTAATGAGATATGCTCATGATCTGAAAACTGAAAGAAAAATGCATCTGCAAGAAGGACGA
AAAGCTCAACAATATCTTGACATGTGCTGGAAACAGATGGATAATAGTAAAAAGAAGTTT
GAAAGAGAATGTAGAGAGGCAGAAAAGGCACAACAGAGTTATGAAAGATTGGATAATGAT
ACTAATGCAACCAAGGCAGATGTTGAAAAGGCCAAACAGCAGTTGAATCTGCGTACGCAT
ATGGCCGATGAAAATAAAAATGAATATGCTGCACAATTACAAAACTTTAATGGAGAACAA
CATAAACATTTTTATGTAGTGATTCCTCAGATTTACAAGCAACTACAAGAAATGGACGAA
CGAAGGACTATTAAACTCAGTGAGTGTTACAGAGGATTTGCTGACTCAGAACGCAAAGTT
ATTCCCATCATTTCAAAATGTTTGGAAGGAATGATTCTTGCAGCAAAATCAGTTGATGAA
AGAAGAGACTCTCAAATGGTGGTAGACTCCTTCAAATCTGGTTTTGAACCTCCAGGAGAC
TTTCCATTTGAAGATTACAGTCAACATATATATAGAACCATTTCTGATGGGACTATCAGT
GCATCCAAACAGGAGAGTGGGAAGATGGATGCCAAAACCACAGTAGGAAAGGCCAAGGGC
AAATTGTGGCTCTTTGGAAAGAAGCCAAAGCCACAGTCCCCACCCTTAACCCCTACTAGT
TTATTCACATCCAGTACTCCTAATGGGTCCCAGTTTCTCACATTCTCCATTGAGCCCGTG
CATTATTGTATGAATGAAATAAAAACAGGGAAGCCCAGAATTCCTTCTTTCAGAAGCCTC
AAAAGAGGGTGGTCGGTGAAGATGGGCCCAGCACTAGAAGATTTCAGTCATCTGCCACCA
GAACAGAGACGTAAAAAACTACAGCAGCGCATTGATGAACTTAACAGAGAACTACAGAAA
GAATCAGACCAAAAAGATGCACTCAACAAAATGAAAGATGTATATGAGAAGAATCCACAA
ATGGGGGATCCAGGGAGTTTGCAGCCTAAATTAGCAGAGACCATGAATAACATTGACCGC
CTACGAATGGAAATCCATAAGAATGAGGCTTGGCTCTCTGAAGTCGAAGGCAAAACAGGT
GGGAGAGGAGACAGAAGACATAGCAGTGACATAAATCATCTTGTAACACAGGGACGAGAA
AGTCCTGAGGGAAGTTACACTGATGATGCAAACCAGGAAGTCCGTGGGCCACCCCAGCAG
CATGGTCACCACAATGAGTTTGATGATGAATTTGAGGATGATGATCCCTTGCCTGCTATT
GGACACTGCAAAGCTATCTACCCTTTTGATGGACATAATGAAGGTACTCTAGCAATGAAA
GAAGGTGAAGTTCTCTACATTATAGAGGAGGACAAAGGTGACGGATGGACAAGAGCTCGG
AGACAGAACGGTGAAGAAGGCTACGTTCCCACGTCATACATAGATGTAACTCTAGAGAAA
AACAGTAAAGGTTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 605 |
| Molecular Weight
| 69977.0 |
| Theoretical pI
| 6.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Formin-binding protein 1-like
MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK
DEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGR
KAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTH
MADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKV
IPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTIS
ASKQESGKMDAKTTVGKAKGKLWLFGKKPKPQSPPLTPTSLFTSSTPNGSQFLTFSIEPV
HYCMNEIKTGKPRIPSFRSLKRGVSLIMGPALEDFSHLPPEQRRKKLQQRIDELNRELQK
ESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTG
GRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAI
GHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTLEK
NSKGS
|
| External Links |
|---|
| GenBank ID Protein
| 256600192 |
| UniProtKB/Swiss-Prot ID
| Q5T0N5 |
| UniProtKB/Swiss-Prot Entry Name
| FBP1L_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001164473.2 |
| GeneCard ID
| FNBP1L |
| GenAtlas ID
| FNBP1L |
| HGNC ID
| HGNC:20851 |
| References |
|---|
| General References
| Not Available |