| Identification |
|---|
| HMDB Protein ID
| CDBP03600 |
| Secondary Accession Numbers
| Not Available |
| Name
| Exocyst complex component 7 |
| Description
| Not Available |
| Synonyms
|
- Exocyst complex component Exo70
|
| Gene Name
| EXOC7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in exocytosis |
| Specific Function
| Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion |
| GO Classification
|
| Component |
| macromolecular complex |
| protein complex |
| exocyst |
| Process |
| establishment of localization |
| transport |
| exocytosis |
| vesicle-mediated transport |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Peripheral membrane protein
- cytosol
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q25.1 |
| SNPs
| EXOC7 |
| Gene Sequence
|
>2208 bp
ATGATTCCCCCACAGGAGGCATCCGCTCGACGGCGGGAGATTGAGGACAAGCTGAAGCAG
GAGGAGGAGACTCTGTCCTTCATCCGAGACAGCCTGGAGAAGAGCGACCAGCTCACTAAG
AACATGGTGTCTATCTTATCATCCTTTGAGAGCCGCCTTATGAAGCTGGAGAACTCCATC
ATCCCTGTGCACAAGCAGACGGAGAATCTGCAGCGGCTGCAGGAGAATGTTGAGAAGACG
CTGTCCTGCCTGGACCATGTCATCAGCTACTACCATGTGGCCAGTGACACTGAGAAGATC
ATCAGAGAGGGCCCCACAGGTAGGCTGGAAGAGTACCTGGGAAGCATGGCCAAGATTCAG
AAGGCAGTGGAGTATTTCCAGGACAACAGCCCAGACAGCCCGGAACTCAACAAAGTGAAA
CTGCTCTTTGAGCGCGGGAAGGAGGCCCTGGAGTCCGAATTTCGCAGCCTGATGACGCGG
CACAGTAAGGTCGTCTCGCCCGTGCTCATCTTGGATCTGATCAGTGGTGACGATGATCTG
GAGGCCCAGGAGGACGTGACCCTGGAGCACCTGCCCGAGAGCGTGCTCCAGGATGTCATT
CGCATCTCCCGCTGGCTGGTGGAATATGGCCGCAACCAAGATTTCATGAACGTCTACTAC
CAGATACGCTCCAGCCAGCTGGACCGCTCCATCAAAGGACTGAAGGAGCATTTCCATAAG
AGCAGTTCTTCCTCTGGGGTTCCCTACTCCCCTGCTATCCCCAACAAGAGGAAAGACACA
CCTACCAAGAAGCCAGTCAAGCGGCCAGGGACGATCCGTAAGGCTCAGAACCTTCTGAAA
CAGTATTCCCAGCATGGTCTAGATGGGAAAAAGGGGGGCTCTAACCTCATTCCTCTGGAA
GGGCTTCTTCCCTGTACCCCAAGGGGCGGCCTGCCTGGCCCCTGGATAAACGCTGCTTGT
GTTTGTGCGGCCGACATCTCGCCAGGTCACGAGCATGATTTCCGAGTTAAGCACCTGTCC
GAGGCCTTGAACGACAAGCACGGGCCGCTGGCCGGGAGAGATGACATGCTGGACGTGGAG
ACCGATGCCTACATCCACTGCGTCAGTGCCTTCGTCAAGCTGGCGCAGAGCGAGTACCAG
CTGCTGGCCGACATCATCCCCGAGCACCACCAGAAGAAGACCTTCGACTCCCTGATACAG
GATGCCCTGGATGGGCTGATGCTTGAAGGGGAGAACATCGTGTCTGCTGCCCGGAAGGCC
ATTGTGCGACACGACTTCTCCACGGTGCTCACCGTCTTCCCCATCCTGCGACACCTCAAG
CAGACCAAGCCTGAGTTTGACCAGGTGCTCCAGGGCACGGCTGCCAGCACAAAGAACAAG
CTGCCTGGCCTCATCACATCCATGGAGACCATCGGTGCCAAAGCGCTGGAGGACTTCGCA
GACAACATCAAGAATGACCCGGACAAGGAGTACAACATGCCGAAGGACGGCACCGTACAC
GAGCTCACCAGCAATGCCATCCTCTTCCTGCAGCAGCTTTTGGACTTCCAGGAGACGGCA
GGCGCCATGCTGGCCTCCCAAGAGACCAGCTCTTCGGCCACCAGCTACAGCTCTGAGTTC
AGCAAGCGGCTGCTAAGCACCTATATCTGTAAAGTGCTGGGCAACCTGCAGTTGAACTTG
CTGAGCAAGTCCAAGGTGTACGAGGACCCAGCTCTGAGCGCCATCTTCCTGCACAACAAC
TACAATTACATCCTCAAGTCCCTGGAGAAGTCTGAACTGATCCAGCTGGTGGCAGTGACA
CAGAAGACTGCTGAGCGCTCCTACCGGGAGCACATTGAGCAGCAGATCCAGACCTACCAG
CGCAGCTGGTTAAAGGTGACTGATTACATCGCAGAGAAGAATCTACCTGTGTTCCAGCCG
GGAGTCAAGCTCCGGGACAAGGAGCGGCAGATTATCAAGGAGCGTTTTAAGGGCTTCAAT
GATGGCCTCGAAGAACTGTGCAAAATCCAGAAGGCCTGGGCTATTCCAGACACAGAGCAG
AGGGACAGGATTCGCCAGGCCCAGAAGACCATTGTCAAGGAGACCTACGGGGCCTTTCTA
CAGAAGTTTGGCAGCGTGCCCTTCACCAAGAACCCGGAGAAGTACATCAAGTACGGGGTG
GAGCAGGTGGGCGACATGATCGATCGCCTTTTCGACACCTCTGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 735 |
| Molecular Weight
| 83381.2 |
| Theoretical pI
| 6.77 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Exocyst complex component 7
MIPPQEASARRREIEDKLKQEEETLSFIRDSLEKSDQLTKNMVSILSSFESRLMKLENSI
IPVHKQTENLQRLQENVEKTLSCLDHVISYYHVASDTEKIIREGPTGRLEEYLGSMAKIQ
KAVEYFQDNSPDSPELNKVKLLFERGKEALESEFRSLMTRHSKVVSPVLILDLISGDDDL
EAQEDVTLEHLPESVLQDVIRISRWLVEYGRNQDFMNVYYQIRSSQLDRSIKGLKEHFHK
SSSSSGVPYSPAIPNKRKDTPTKKPVKRPGTIRKAQNLLKQYSQHGLDGKKGGSNLIPLE
GLLPCTPRGGLPGPWINAACVCAADISPGHEHDFRVKHLSEALNDKHGPLAGRDDMLDVE
TDAYIHCVSAFVKLAQSEYQLLADIIPEHHQKKTFDSLIQDALDGLMLEGENIVSAARKA
IVRHDFSTVLTVFPILRHLKQTKPEFDQVLQGTAASTKNKLPGLITSMETIGAKALEDFA
DNIKNDPDKEYNMPKDGTVHELTSNAILFLQQLLDFQETAGAMLASQETSSSATSYSSEF
SKRLLSTYICKVLGNLQLNLLSKSKVYEDPALSAIFLHNNYNYILKSLEKSELIQLVAVT
QKTAERSYREHIEQQIQTYQRSWLKVTDYIAEKNLPVFQPGVKLRDKERQIIKERFKGFN
DGLEELCKIQKAWAIPDTEQRDRIRQAQKTIVKETYGAFLQKFGSVPFTKNPEKYIKYGV
EQVGDMIDRLFDTSA
|
| External Links |
|---|
| GenBank ID Protein
| 223718046 |
| UniProtKB/Swiss-Prot ID
| Q9UPT5 |
| UniProtKB/Swiss-Prot Entry Name
| EXOC7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001145297.2 |
| GeneCard ID
| EXOC7 |
| GenAtlas ID
| EXOC7 |
| HGNC ID
| HGNC:23214 |
| References |
|---|
| General References
| Not Available |