| Identification |
|---|
| HMDB Protein ID
| CDBP03595 |
| Secondary Accession Numbers
| Not Available |
| Name
| Eukaryotic peptide chain release factor subunit 1 |
| Description
| Not Available |
| Synonyms
|
- Eukaryotic release factor 1
- Protein Cl1
- TB3-1
- eRF1
|
| Gene Name
| ETF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in translation release factor activity, codon specific |
| Specific Function
| Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA |
| GO Classification
|
| Component |
| cytoplasm |
| cell part |
| intracellular part |
| Function |
| binding |
| translation termination factor activity |
| translation release factor activity |
| translation release factor activity, codon specific |
| nucleic acid binding |
| translation factor activity, nucleic acid binding |
| rna binding |
| Process |
| cellular component organization or biogenesis |
| cellular component organization |
| cellular component disassembly |
| macromolecular complex disassembly |
| cellular macromolecular complex disassembly |
| cellular protein complex disassembly |
| translational termination |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31.1 |
| SNPs
| ETF1 |
| Gene Sequence
|
>1314 bp
ATGGCGGACGACCCCAGTGCTGCCGACAGGAACGTGGAGATCTGGAAGATCAAGAAGCTC
ATTAAGAGCTTGGAGGCGGCCCGCGGCAATGGCACCAGCATGATATCATTGATCATTCCT
CCCAAAGACCAGATTTCACGAGTGGCAAAAATGTTAGCGGATGAGTTTGGAACTGCATCT
AACATTAAGTCACGAGTAAACCGCCTTTCAGTCCTGGGAGCCATTACATCTGTACAACAA
AGACTCAAACTTTATAACAAAGTACCTCCAAATGGTCTGGTTGTATACTGTGGAACAATT
GTAACAGAAGAAGGAAAGGAAAAGAAAGTCAACATTGACTTTGAACCTTTCAAACCAATT
AATACGTCATTGTATTTGTGTGACAACAAATTCCATACAGAGGCTCTTACAGCACTACTT
TCAGATGATAGCAAGTTTGGATTCATTGTAATAGATGGTAGTGGTGCACTTTTTGGCACA
CTCCAAGGAAACACAAGAGAAGTCCTGCACAAATTCACTGTGGATCTCCCAAAGAAACAC
GGTAGAGGAGGTCAGTCAGCCTTGCGTTTTGCCCGTTTAAGAATGGAAAAGCGACATAAC
TATGTTCGGAAAGTAGCAGAGACTGCTGTGCAGCTGTTTATTTCTGGGGACAAAGTGAAT
GTGGCTGGTCTAGTTTTAGCTGGATCCGCTGACTTTAAAACTGAACTAAGTCAATCTGAT
ATGTTTGATCAGAGGTTACAATCAAAAGTTTTAAAATTAGTTGATATATCCTATGGTGGT
GAAAATGGATTCAACCAAGCTATTGAGTTATCTACTGAAGTCCTCTCCAACGTGAAATTC
ATTCAAGAGAAGAAATTAATAGGACGATACTTTGATGAAATCAGCCAGGACACGGGCAAG
TACTGTTTTGGCGTTGAAGATACACTAAAGGCTTTGGAAATGGGAGCTGTAGAAATTCTA
ATAGTCTATGAAAATCTGGATATAATGAGATATGTTCTTCATTGCCAAGGCACAGAAGAG
GAGAAAATTCTCTATCTAACTCCAGAGCAAGAAAAGGATAAATCTCATTTCACAGACAAA
GAGACCGGACAGGAACATGAGCTTATCGAGAGCATGCCCCTGTTGGAATGGTTTGCTAAC
AACTATAAAAAATTTGGAGCTACGTTGGAAATTGTCACAGATAAATCACAAGAAGGGTCT
CAGTTTGTGAAAGGATTTGGTGGAATTGGAGGTATCTTGCGGTACCGAGTAGATTTCCAG
GGAATGGAATACCAAGGAGGAGACGATGAATTTTTTGACCTTGATGACTACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 437 |
| Molecular Weight
| 49030.5 |
| Theoretical pI
| 5.41 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Eukaryotic peptide chain release factor subunit 1
MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTAS
NIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPI
NTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKH
GRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSD
MFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGK
YCFGVEDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDK
ETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQ
GMEYQGGDDEFFDLDDY
|
| External Links |
|---|
| GenBank ID Protein
| 5499721 |
| UniProtKB/Swiss-Prot ID
| P62495 |
| UniProtKB/Swiss-Prot Entry Name
| ERF1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF095901 |
| GeneCard ID
| ETF1 |
| GenAtlas ID
| ETF1 |
| HGNC ID
| HGNC:3477 |
| References |
|---|
| General References
| Not Available |