| Identification |
|---|
| HMDB Protein ID
| CDBP03572 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dedicator of cytokinesis protein 7 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| DOCK7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanyl-nucleotide exchange factor activity |
| Specific Function
| Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization |
| GO Classification
|
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| enzyme regulator activity |
| protein binding |
| gtpase binding |
| enzyme binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
|
| Cellular Location
|
- Cell projection
- axon
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p31.3 |
| SNPs
| DOCK7 |
| Gene Sequence
|
>6330 bp
ATGGCCGAGCGCCGCGCCTTCGCCCAGAAGATCAGCAGAACGGTGGCAGCCGAAGTTAGG
AAGCAGATCTCCGGACAATATAGTGGTTCTCCCCAACTGCTCAAAAACCTTAATATTGTT
GGCAATATATCCCATCACACCACAGTGCCCCTTACCGAAGCAGTAGATCCAGTGGATTTG
GAAGATTACCTCATTACTCATCCTTTGGCTGTGGATTCTGGGCCTTTACGGGATTTGATT
GAATTTCCTCCAGATGATATTGAAGTTGTTTATAGTCCTCGGGACTGCAGAACTCTTGTT
TCAGCTGTACCTGAAGAAAGTGAAATGGATCCACATGTTAGAGACTGTATAAGAAGTTAT
ACAGAAGACTGGGCAATTGTCATCAGAAAATATCATAAATTGGGAACAGGATTTAATCCC
AATACATTAGATAAACAGAAAGAAAGGCAAAAAGGTTTGCCAAAACAAGTTTTTGAATCT
GATGAAGCTCCAGATGGCAACAGCTACCAGGATGATCAAGATGACCTTAAAAGACGTTCA
ATGTCAATAGATGATACCCCAAGGGGTAGCTGGGCCTGTAGTATCTTTGACTTGAAAAAT
TCACTTCCTGATGCTTTGCTTCCCAATTTACTTGATCGAACTCCAAATGAAGAAATAGAC
CGTCAGAATGATGACCAAAGGAAATCAAACCGTCACAAAGAACTTTTTGCTTTGCATCCA
TCACCAGATGAGGAAGAACCAATAGAACGGCTTAGTGTTCCTGATATACCCAAAGAACAT
TTTGGTCAAAGACTTCTTGTAAAATGCTTATCACTCAAGTTTGAAATTGAAATTGAACCC
ATTTTTGCAAGTTTGGCTTTATATGATGTCAAGGAAAAGAAAAAGATTTCAGAAAACTTT
TATTTTGACCTTAATTCTGAGCAGATGAAAGGGTTGTTACGTCCACATGTACCACCTGCT
GCCATTACTACCCTGGCAAGATCAGCAATTTTTTCTATCACTTATCCTTCCCAAGATGTT
TTTCTTGTAATAAAGCTAGAAAAAGTCCTACAGCAAGGAGACATTGGAGAGTGTGCAGAA
CCATATATGATTTTCAAAGAAGCAGATGCCACCAAGAATAAAGAAAAACTGGAGAAACTG
AAGAGTCAAGCAGATCAGTTTTGCCAAAGACTTGGGAAATATCGCATGCCTTTTGCTTGG
ACTGCAATCCATTTAATGAATATTGTTAGCAGTGCTGGGAGTTTGGAAAGAGATTCTACA
GAAGTAGAAATCAGTACTGGAGAACGAAAAGGGTCTTGGTCAGAGAGGAGGAATTCTAGT
ATTGTTGGCAGACGATCACTTGAAAGGACAACAAGTGGAGATGATGCTTGTAACTTGACG
AGCTTTCGACCAGCTACTCTCACAGTGACAAATTTTTTTAAGCAGGAAGGAGACCGCTTA
AGTGATGAAGATCTCTACAAATTCCTTGCTGATATGAGAAGGCCATCTTCTGTCTTACGG
CGACTAAGACCTATTACAGCTCAGCTCAAGATAGACATTTCTCCCGCACCTGAAAATCCC
CATTATTGCCTAACTCCGGAGCTGCTTCAAGTGAAGCTTTACCCTGACAGTAGAGTTAGA
CCTACCAGAGAAATCTTAGAGTTTCCCGCAAGGGATGTTTATGTTCCAAACACTACTTAC
AGAAATCTTCTCTACATATACCCTCAGAGTCTTAATTTTGCCAATCGTCAAGGTTCTGCT
AGAAATATAACAGTGAAAGTCCAGTTTATGTATGGAGAGGATCCAAGCAATGCCATGCCG
GTAATCTTTGGTAAATCTAGCTGTTCAGAATTTTCAAAGGAAGCCTATACAGCCGTAGTA
TATCATAACAGGTCTCCTGATTTTCATGAAGAAATCAAGGTTAAGCTTCCTGCTACTTTA
ACTGACCATCATCACTTGCTTTTTACTTTTTATCATGTTAGTTGTCAACAAAAACAAAAT
ACTCCTCTTGAAACACCAGTTGGATATACATGGATACCAATGCTTCAGAATGGACGGTTG
AAGACTGGCCAGTTTTGCTTGCCAGTCTCATTGGAAAAACCACCACAGGCTTATTCTGTA
CTGTCTCCTGAGGTTCCTCTACCTGGCATGAAATGGGTAGATAATCACAAAGGTGTTTTT
AATGTTGAAGTTGTTGCTGTTTCGTCTATCCATACACAAGATCCTTATCTTGACAAATTT
TTTGCTCTGGTCAATGCTCTGGATGAACACCTGTTCCCAGTCCGAATTGGGGACATGCGA
ATCATGGAAAATAACTTAGAAAATGAATTGAAGAGCAGTATTTCAGCACTGAATTCATCC
CAGCTGGAACCAGTGGTCCGATTTCTTCATCTTCTGCTAGATAAACTGATACTTTTAGTT
ATTAGACCTCCTGTCATTGCTGGCCAAATAGTTAACCTAGGTCAAGCATCTTTTGAAGCC
ATGGCATCAATTATAAATCGACTTCACAAAAACTTGGAAGGAAATCATGACCAGCATGGC
AGAAACAGCCTTCTTGCATCATATATTCATTATGTTTTCCGCCTACCAAATACTTACCCT
AATTCATCATCACCAGGTCCTGGGGGTTTGGGAGGATCAGTGCATTATGCCACAATGGCT
AGATCTGCGGTGAGACCTGCAAGCCTTAATTTAAATCGTTCTCGAAGCCTTAGTAATAGC
AATCCAGATATATCTGGGACTCCCACGTCACCAGATGATGAAGTTCGATCAATCATCGGG
AGTAAGGCTATGGATCGAAGTTGTAATCGTATGTCTTCGCACACAGAGACGTCAAGTTTC
TTACAAACATTAACGGGACGCTTACCAACTAAAAAGCTTTTTCACGAGGAGCTGGCTTTG
CAGTGGGTTGTTTGCAGTGGCAGCGTTCGGGAATCAGCTTTGCAACAAGCCTGGTTCTTT
TTTGAATTAATGGTAAAGAGCATGGTGCACCATTTATACTTTAATGATAAACTTGAGGCT
CCAAGGAAAAGTCGTTTTCCAGAACGTTTCATGGATGACATTGCAGCTCTTGTCAGCACG
ATTGCTAGTGATATAGTTTCACGATTTCAGAAGGACACAGAAATGGTTGAGAGACTCAAT
ACAAGCCTTGCATTCTTTCTCAATGATCTGTTGTCTGTTATGGACAGAGGATTTGTTTTT
AGCCTTATAAAGTCCTGCTATAAACAGGTGTCTTCAAAGCTTTACTCATTACCGAATCCC
AGTGTTCTGGTGTCCTTGAGGCTGGATTTTCTACGAATCATCTGCAGTCATGAGCACTAT
GTTACATTAAACTTACCCTGCAGCTTACTTACTCCACCTGCATCTCCATCACCTTCTGTT
TCTTCTGCAACATCTCAGAGTTCTGGATTTTCTACGAATGTACAAGACCAAAAGATTGCA
AATATGTTTGAATTATCCGTGCCTTTCCGCCAACAGCATTATTTGGCAGGACTTGTGTTA
ACAGAGCTGGCTGTCATTTTAGACCCTGATGCTGAAGGACTGTTTGGATTGCATAAGAAA
GTCATCAATATGGTACACAATTTACTCTCCAGTCACGACTCAGACCCGCGGTACTCTGAC
CCTCAGATAAAGGCTCGAGTGGCCATGTTGTATCTACCTCTGATTGGTATTATCATGGAA
ACTGTACCTCAGCTGTATGATTTTACAGAAACTCACAATCAACGAGGAAGACCAATTTGT
ATAGCCACTGATGATTATGAAAGTGAGAGCGGAAGTATGATAAGCCAGACCGTTGCCATG
GCAATCGCAGGGACATCGGTCCCTCAACTAACAAGGCCTGGCAGTTTCCTCCTCACGTCA
ACGAGTGGCAGGCAACACACTACCTTTTCAGCAGAATCAAGTCGAAGCCTTTTGATCTGT
CTACTTTGGGTTCTCAAAAATGCAGATGAAACAGTTCTACAGAAGTGGTTTACAGATCTC
TCAGTCTTGCAGCTAAACCGGCTATTAGATCTGCTTTATCTCTGTGTGTCTTGCTTTGAG
TATAAAGGGAAAAAAGTGTTTGAACGAATGAATAGCTTGACCTTTAAGAAATCAAAAGAC
ATGAGAGCAAAGCTTGAAGAAGCTATTCTTGGGAGCATAGGTGCCAGGCAAGAAATGGTA
CGGCGAAGCCGAGGACAGCTCGGTACGTACACAATAGCTTCTCCTCCTGAGAGAAGCCCA
TCTGGAAGTGCCTTTGGAAGTCAAGAAAATTTGAGGTGGAGGAAAGATATGACTCACTGG
CGTCAAAACACAGAGAAGCTTGACAAATCAAGAGCAGAGATTGAACACGAAGCACTGATT
GATGGAAACCTGGCTACAGAAGCAAACCTAATCATTTTAGATACATTAGAGATTGTTGTT
CAGACCGTTTCTGTAACGGAATCCAAAGAGAGCATTCTTGGTGGAGTGCTAAAAGTGCTA
CTACACAGCATGGCCTGTAACCAAAGTGCAGTTTATCTACAACACTGTTTTGCTACACAG
AGAGCCTTGGTTTCAAAGTTTCCTGAACTCTTATTTGAAGAAGAGACAGAGCAGTGTGCT
GATTTATGCCTCAGGCTTCTCCGACACTGTAGCAGTAGCATCGGTACAATACGGTCACAC
GCCAGTGCCTCCCTTTACCTACTAATGAGGCAAAACTTTGAGATTGGGAATAACTTTGCC
AGGGTTAAAATGCAGGTAACAATGTCACTATCCTCCTTGGTGGGCACATCTCAGAATTTT
AATGAAGAATTCTTAAGACGTTCTCTAAAGACTATATTGACATATGCTGAAGAAGATCTG
GAATTGAGGGAAACAACATTTCCTGATCAGGTCCAGGATCTGGTTTTCAATCTCCATATG
ATTCTTTCTGATACTGTGAAAATGAAGGAACACCAGGAGGATCCTGAAATGTTGATTGAT
CTAATGTACAGAATTGCCAAGGGTTACCAGACCTCTCCAGATCTGCGATTGACCTGGTTG
CAGAACATGGCAGGCAAGCACTCAGAACGAAGCAATCATGCTGAAGCTGCACAGTGTCTA
GTCCACTCAGCAGCACTTGTTGCTGAATATTTGAGCATGCTGGAGGACCGGAAATATCTT
CCTGTGGGATGTGTAACATTTCAGAATATTTCATCTAATGTTTTAGAAGAATCTGCGGTC
TCAGATGATGTGGTATCTCCAGATGAAGAAGGTATCTGCTCTGGAAAATACTTTACTGAG
TCAGGACTTGTGGGATTACTGGAACAAGCAGCTGCTTCCTTCTCTATGGCTGGCATGTAT
GAAGCAGTTAATGAAGTTTACAAAGTACTTATTCCTATTCATGAAGCTAATCGGGATGCA
AAGAAACTATCCACAATTCATGGTAAACTTCAAGAAGCATTCAGCAAAATTGTTCATCAG
AGTACTGGCTGGGAGCGGATGTTTGGCACCTATTTTCGTGTTGGTTTTTATGGAACCAAG
TTCGGGGATTTGGATGAACAAGAATTTGTTTACAAGGAGCCTGCAATAACCAAACTTGCA
GAGATATCTCACAGATTGGAGGGATTTTACGGAGAAAGATTTGGAGAGGATGTGGTTGAA
GTAATCAAAGACTCTAATCCTGTAGACAAGTGTAAATTAGATCCTAACAAGGCATATATT
CAGATTACCTATGTGGAGCCATACTTTGACACATATGAGATGAAGGACAGAATCACCTAT
TTCGACAAAAATTACAATCTTCGTCGATTCATGTACTGTACACCCTTTACTTTAGATGGC
CGTGCCCATGGGGAACTTCATGAACAATTCAAAAGGAAGACCATTCTGACTACGTCTCAT
GCCTTTCCTTATATTAAAACAAGGGTCAATGTCACTCATAAAGAAGAGATCATCTTAACA
CCAATTGAAGTTGCTATTGAGGACATGCAGAAAAAGACACAGGAGTTGGCATTTGCAACA
CATCAGGATCCCGCAGACCCCAAAATGCTTCAGATGGTACTCCAGGGATCTGTAGGCACC
ACAGTGAATCAGGGGCCTTTGGAAGTTGCCCAGGTTTTTCTGTCTGAAATACCTAGTGAC
CCAAAGCTCTTCAGACATCATAATAAACTGCGACTCTGCTTTAAAGATTTTACTAAAAGG
TGTGAAGATGCCTTAAGAAAAAATAAGAGCTTAATTGGGCCGGATCAAAAGGAGTATCAA
AGGGAACTGGAGAGAAACTATCATCGCCTTAAAGAGGCCCTACAGCCACTGATCAACAGA
AAGATCCCTCAGTTATACAAGGCAGTATTGCCTGTCACCTGCCACAGAGATTCCTTCAGT
CGAATGAGCCTTCGCAAAATGGATCTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 2140 |
| Molecular Weight
| 242558.3 |
| Theoretical pI
| 6.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dedicator of cytokinesis protein 7
MAERRAFAQKISRTVAAEVRKQISGQYSGSPQLLKNLNIVGNISHHTTVPLTEAVDPVDL
EDYLITHPLAVDSGPLRDLIEFPPDDIEVVYSPRDCRTLVSAVPEESEMDPHVRDCIRSY
TEDWAIVIRKYHKLGTGFNPNTLDKQKERQKGLPKQVFESDEAPDGNSYQDDQDDLKRRS
MSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDRQNDDQRKSNRHKELFALHP
SPDEEEPIERLSVPDIPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENF
YFDLNSEQMKGLLRPHVPPAAITTLARSAIFSITYPSQDVFLVIKLEKVLQQGDIGECAE
PYMIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLERDST
EVEISTGERKGSWSERRNSSIVGRRSLERTTSGDDACNLTSFRPATLTVTNFFKQEGDRL
SDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELLQVKLYPDSRVR
PTREILEFPARDVYVPNTTYRNLLYIYPQSLNFANRQGSARNITVKVQFMYGEDPSNAMP
VIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQN
TPLETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVF
NVEVVAVSSIHTQDPYLDKFFALVNALDEHLFPVRIGDMRIMENNLENELKSSISALNSS
QLEPVVRFLHLLLDKLILLVIRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHG
RNSLLASYIHYVFRLPNTYPNSSSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNS
NPDISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQAMDRSCN
RMSSHTETSSFLQTLTGRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMV
HHLYFNDKLEAPRKSRFPERFMDDIAALVSTIASDIVSRFQKDTEMVERLNTSLAFFLND
LLSVMDRGFVFSLIKSCYKQVSSKLYSLPNPSVLVSLRLDFLRIICSHEHYVTLNLPCSL
LTPPASPSPSVSSATSQSSGFSTNVQDQKIANMFELSVPFRQQHYLAGLVLTELAVILDP
DAEGLFGLHKKVINMVHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFT
ETHNQRGRPICIATDDYESESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTTF
SAESSRSLLICLLWVLKNADETVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFER
MNSLTFKKSKDMRAKLEEAILGSIGARQEMVRRSRGQLGTYTIASPPERSPSGSAFGSQE
NLRWRKDMTHWRQNTEKLDKSRAEIEHEALIDGNLATEANLIILDTLEIVVQTVSVTESK
ESILGGVLKVLLHSMACNQSAVYLQHCFATQRALVSKFPELLFEEETEQCADLCLRLLRH
CSSSIGTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNEEFLRRSL
KTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAKGY
QTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLEDRKYLPVGCVTFQN
ISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMYEAVNEVYKV
LIPIHEANRDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTKFGDLDEQEF
VYKEPAITKLAEISHRLEGFYGERFGEDVVEVIKDSNPVDKCKLDPNKAYIQITYVEPYF
DTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTILTTSHAFPYIKTRV
NVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKMLQMVLQGSVGTTVNQGPLEV
AQVFLSEIPSDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELERNYHR
LKEALQPLINRKIPQLYKAVLPVTCHRDSFSRMSLRKMDL
|
| External Links |
|---|
| GenBank ID Protein
| 54112429 |
| UniProtKB/Swiss-Prot ID
| Q96N67 |
| UniProtKB/Swiss-Prot Entry Name
| DOCK7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| DOCK7 |
| GenAtlas ID
| DOCK7 |
| HGNC ID
| HGNC:19190 |
| References |
|---|
| General References
| Not Available |