| Identification |
|---|
| HMDB Protein ID
| CDBP03571 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dedicator of cytokinesis protein 6 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| DOCK6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanyl-nucleotide exchange factor activity |
| Specific Function
| Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP |
| GO Classification
|
| Function |
| enzyme regulator activity |
| protein binding |
| gtpase binding |
| enzyme binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.2 |
| SNPs
| DOCK6 |
| Gene Sequence
|
>6144 bp
ATGGCTGCCTCCGAGCGCCGCGCCTTCGCGCACAAGATCAACAGGACGGTGGCCGCAGAG
GTGCGGAAGCAGGTGTCCCGGGAACGCAGTGGCTCCCCCCACTCCAGCAGGCGCTGCAGC
AGCTCCCTGGGGGTCCCACTGACTGAAGTTGTCGAGCCCCTGGACTTTGAGGATGTACTT
CTGAGCCGGCCACCAGATGCTGAGCCCGGGCCCCTCAGGGACCTGGTAGAATTCCCAGCT
GATGACTTGGAGCTGCTGCTGCAGCCCCGGGAATGCCGGACCACGGAGCCCGGGATCCCC
AAGGATGAAAAACTGGATGCCCAGGTGAGGGCCGCGGTGGAGATGTATATTGAGGACTGG
GTCATTGTCCACAGAAGGTATCAGTACCTGAGTGCAGCATACAGCCCCGTCACCACAGAC
ACACAGCGGGAGCGACAGAAGGGCCTCCCCCGCCAGGTCTTTGAGCAGGATGCTTCTGGA
GACGAGAGGTCCGGCCCTGAGGACTCGAATGACTCCCGGCGTGGCTCGGGCTCCCCGGAA
GACACCCCTCGAAGCAGTGGTGCCTCTAGCATCTTCGACCTGAGGAACCTGGCAGCTGAC
TCATTGCTGCCCTCTCTGCTAGAGCGGGCGGCCCCAGAAGATGTGGACCGGCGCAATGAA
ACCCTTCGACGGCAGCACCGGCCCCCGGCCCTGCTCACCCTCTACCCGGCACCTGACGAG
GATGAAGCCGTGGAACGCTGTAGCCGCCCAGAGCCACCCCGCGAGCACTTTGGACAAAGG
ATCTTGGTCAAGTGTCTGTCGCTCAAGTTCGAGATTGAAATTGAGCCCATCTTTGGGATC
TTGGCTCTGTATGATGTGCGGGAGAAAAAGAAGATCTCGGAGAACTTCTACTTCGACCTG
AACTCGGACTCCATGAAGGGGCTGCTTCGGGCTCATGGCACCCACCCTGCCATCTCCACC
CTGGCCCGCTCTGCCATCTTCTCTGTGACCTACCCCTCACCTGACATCTTCCTGGTCATC
AAGTTGGAGAAGGTGCTTCAGCAAGGGGACATCAGTGAGTGCTGTGAGCCTTACATGGTG
TTGAAAGAAGTGGACACAGCCAAGAACAAAGAGAAGCTAGAGAAGCTGCGCCTGGCGGCC
GAGCAGTTCTGCACCCGCCTGGGCCGCTACCGCATGCCCTTCGCCTGGACGGCCGTGCAC
TTGGCCAACATCGTGAGCAGCGCTGGGCAGCTGGACCGGGACTCTGACTCGGAGGGCGAG
CGCCGGCCAGCCTGGACAGACCGCCGCCGTCGGGGGCCCCAGGACCGGGCGAGTAGTGGG
GACGACGCCTGCAGCTTCTCTGGCTTCCGTCCAGCCACGCTAACTGTCACAAACTTCTTT
AAGCAGGAGGCTGAGCGACTCAGTGACGAGGACCTCTTCAAGTTCCTGGCTGACATGAGG
CGCCCGTCGTCCCTGCTGCGGCGACTACGTCCTGTGACTGCCCAGCTCAAGATCGACATT
TCTCCGGCTCCTGAAAATCCCCACTTCTGCCTCTCCCCTGAGCTGCTTCATATCAAGCCC
TACCCGGACCCCAGGGGCCGGCCCACCAAGGAGATTCTGGAGTTCCCCGCCCGCGAAGTC
TATGCCCCCCATACCAGCTACAGGAACCTGCTGTACGTGTACCCGCACAGCCTCAACTTC
AGCAGCCGCCAGGGCTCCGTGCGCAACCTTGCTGTGCGAGTGCAGTACATGACAGGCGAG
GACCCCAGCCAGGCTCTGCCGGTCATCTTTGGCAAGTCCAGCTGCAGTGAATTTACCCGC
GAGGCCTTCACACCGGTGGTCTACCATAACAAGTCCCCCGAGTTCTACGAGGAGTTCAAG
CTGCATCTTCCAGCCTGCGTGACAGAGAACCATCACCTGCTGTTCACCTTCTACCATGTC
AGCTGCCAGCCCCGGCCGGGCACTGCCCTGGAGACACCCGTGGGCTTTACTTGGATCCCA
CTGCTGCAGCACGGGCGCCTGAGGACCGGCCCCTTCTGTCTCCCAGTGTCTGTGGACCAG
CCGCCGCCCAGCTATTCCGTGCTCACACCCGATGTGGCGCTTCCGGGCATGCGCTGGGTG
GACGGTCACAAGGGCGTGTTCAGTGTGGAGCTCACAGCCGTGTCCTCTGTGCACCCCCAG
GACCCCTACCTGGACAAATTCTTCACCCTGGTGCACGTCCTGGAGGAGGGAGCCTTCCCA
TTCCGGCTCAAGGACACTGTGCTGAGCGAGGGCAACGTGGAGCAGGAGCTGCGGGCCAGT
CTTGCAGCACTGCGCCTGGCCAGCCCCGAACCCCTTGTGGCCTTCTCCCACCACGTGCTG
GACAAGCTCGTGCGTCTGGTCATCAGGCCCCCGATCATCAGTGGCCAGATTGTGAACCTG
GGCCGTGGAGCCTTTGAAGCAATGGCCCATGTAGTCAGCCTTGTTCACCGGAGCCTGGAG
GCAGCCCAGGATGCCCGCGGTCACTGCCCACAGCTGGCTGCCTACGTCCACTACGCCTTT
CGCCTTCCTGGCACTGAGCCCAGCCTCCCGGATGGGGCCCCTCCAGTGACAGTGCAGGCT
GCCACACTGGCCCGTGGCTCTGGTCGCCCCGCAAGCCTCTACCTGGCGCGTTCCAAGAGC
ATCAGCAGCAGCAACCCTGACCTCGCCGTGGCCCCTGGCTCTGTGGATGACGAGGTTTCC
CGCATCCTGGCCAGCAAGCTGCTTCACGAGGAGCTGGCTCTGCAGTGGGTGGTCAGCAGC
AGTGCCGTACGCGAGGCCATCCTCCAGCACGCCTGGTTCTTCTTCCAGCTCATGGTGAAG
AGTATGGCGCTGCACCTGCTGCTTGGCCAGCGACTAGACACACCCCGCAAGCTGCGCTTC
CCCGGACGCTTCCTGGACGACATCACTGCCTTGGTGGGCTCTGTGGGCCTGGAGGTCATC
ACCCGTGTCCACAAGGATGTGGAGCTGGCCGAGCACCTCAACGCCAGCCTGGCTTTCTTC
CTCAGTGACCTTCTGTCCCTGGTGGACCGGGGCTTTGTCTTCAGCCTGGTCCGGGCCCAC
TACAAGCAGGTGGCCACGCGGCTCCAGTCGTCCCCTAATCCAGCAGCCCTGCTGACCCTG
CGCATGGAATTCACCCGCATCCTGTGCAGCCACGAGCACTACGTGACCCTCAACCTCCCC
TGCTGCCCCCTGTCACCTCCAGCCTCGCCCTCCCCCTCTGTGTCCTCCACCACCTCCCAG
AGCTCCACCTTCTCCAGCCAAGCCCCGGACCCCAAGGTGACCAGCATGTTCGAACTGAGT
GGACCATTCCGGCAGCAGCACTTCCTAGCTGGGCTCCTGCTGACGGAGCTGGCACTGGCC
CTCGAACCTGAGGCTGAAGGGGCATTCCTGTTGCACAAGAAGGCCATCAGTGCTGTGCAC
AGCCTGCTATGTGGCCATGACACTGACCCCCGCTACGCCGAGGCCACTGTGAAGGCTCGT
GTGGCCGAGCTGTACCTGCCACTGCTATCGATTGCACGGGATACCTTGCCACGGCTGCAT
GACTTTGCTGAGGGCCCAGGTCAGCGGTCAAGACTGGCCTCAATGCTTGACTCAGACACA
GAAGGCGAAGGGGACATTGCGGGTACCATCAACCCCTCTGTGGCCATGGCCATTGCTGGT
GGCCCCCTAGCCCCTGGCTCCCGGGCCAGCATCTCCCAGGGGCCACCAACGGCTTCTCGC
GCAGGCTGTGCCCTCTCTGCTGAGTCAAGCCGGACCTTGCTGGCGTGTGTGCTGTGGGTG
CTGAAAAACACCGAGCCGGCGCTCCTGCAGCGCTGGGCCACTGACCTGACACTCCCCCAG
CTGGGACGTCTGTTGGATTTGCTGTACCTTTGCCTAGCTGCCTTTGAGTACAAGGGGAAA
AAGGCCTTTGAACGCATCAACAGCCTCACATTCAAAAAATCTCTGGATATGAAGGCGCGG
CTAGAGGAAGCCATTCTGGGTACCATCGGAGCTCGACAAGAAATGGTTCGGCGAAGTCGT
GAGAGGAGCCCGTTTGGGAATCCGGAGAATGTGCGCTGGCGGAAGAGCGTCACACACTGG
AAGCAAACCTCAGACCGCGTGGACAAGACCAAGGATGAAATGGAACACGAGGCCTTGGTG
GAAGGGAACCTGGCAACCGAGGCAAGCCTAGTGGTTCTGGACACACTGGAGATCATCGTG
CAGACGGTGATGCTTTCAGAAGCCCGGGAGAGCGTCTTGGGGGCAGTGCTGAAGGTTGTG
CTGTACAGCCTGGGCAGTGCCCAGAGTGCCCTCTTCTTGCAGCATGGCCTGGCCACCCAG
AGGGCCCTTGTGTCCAAGTTCCCGGAGCTGCTGTTCGAGGAGGACACGGAGCTGTGTGCC
GACCTGTGCCTGAGGCTCCTACGACACTGTGGCAGCCGCATCAGCACCATCCGCACGCAC
GCCAGCGCCTCGCTGTACCTGCTCATGCGACAGAACTTCGAGATCGGCCACAACTTTGCC
CGTGTGAAGATGCAGGTCACCATGTCTCTCTCGTCCCTGGTGGGGACGACGCAGAACTTC
AGTGAAGAGCACCTGCGACGTTCACTCAAAACCATCCTCACCTATGCTGAGGAGGACATG
GGGCTGCGGGACAGCACCTTCGCAGAGCAGGTCCAGGACCTGATGTTCAACCTGCACATG
ATCCTGACGGACACGGTGAAGATGAAGGAACACCAGGAGGACCCTGAGATGCTCATCGAC
CTCATGTACAGAATTGCCCGGGGCTACCAGGGCTCACCGGACCTTCGGCTGACCTGGTTG
CAGAACATGGCCGGGAAGCACGCGGAGCTGGGCAACCACGCCGAGGCCGCCCAGTGCATG
GTGCACGCGGCCGCCCTCGTGGCTGAGTACCTCGCCCTGCTCGAGGACCACCGCCACCTG
CCCGTGGGCTGCGTTTCCTTCCAGAACATCTCATCCAACGTGCTAGAGGAGTCCGCCATC
TCCGACGACATCCTGTCGCCCGACGAGGAGGGCTTCTGCTCCGGGAAGCACTTCACTGAG
CTGGGGCTGGTAGGGTTGCTGGAACAGGCAGCCGGCTACTTCACCATGGGCGGGCTCTAC
GAGGCGGTGAATGAGGTCTACAAGAACCTCATCCCCATCCTGGAAGCCCACCGTGACTAC
AAGAAGCTGGCCGCGGTGCACGGCAAACTGCAGGAGGCCTTCACCAAGATCATGCACCAG
AGTTCCGGCTGGGAGCGCGTGTTCGGGACGTATTTCCGCGTGGGCTTCTACGGCGCCCAC
TTCGGTGACCTGGATGAGCAGGAGTTTGTGTACAAGGAGCCATCGATCACGAAGCTGGCA
GAGATCTCACACCGGCTGGAGGAGTTCTACACGGAGAGATTTGGCGACGACGTCGTTGAG
ATTATCAAAGACTCTAACCCTGTGGACAAGTCCAAGCTTGACTCACAAAAGGCCTACATC
CAGATCACGTATGTGGAACCGTACTTTGATACCTACGAGCTCAAGGACCGGGTGACCTAC
TTTGACCGCAACTATGGGCTTCGCACATTCCTGTTCTGCACGCCGTTCACGCCGGATGGG
CGCGCACACGGGGAGCTGCCCGAGCAACACAAGCGTAAGACGCTGCTCAGCACCGACCAC
GCCTTCCCCTACATCAAGACTCGCATCCGTGTGTGCCACCGGGAGGAGACGGTGCTGACG
CCAGTGGAGGTGGCCATCGAGGACATGCAGAAGAAGACACGGGAGCTGGCCTTTGCCACC
GAGCAGGACCCACCAGATGCTAAGATGCTACAGATGGTGCTTCAGGGCTCTGTAGGGCCC
ACCGTGAACCAGGGTCCCCTGGAGGTGGCCCAGGTGTTTTTAGCAGAGATCCCGGAAGAC
CCCAAGCTCTTCCGGCATCACAACAAATTGCGGCTCTGCTTCAAGGACTTCTGCAAGAAA
TGTGAGGATGCGCTGCGGAAAAATAAGGCCCTGATTGGGCCGGACCAGAAGGAGTACCAC
CGTGAGCTGGAGCGCAACTACTGCCGCCTGCGGGAGGCTCTGCAGCCCCTGCTTACCCAG
CGCCTGCCCCAGCTGATGGCACCCACCCCACCCGGCCTCAGGAACTCCTTGAACAGAGCA
AGTTTCCGAAAGGCAGACCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 2047 |
| Molecular Weight
| 229555.6 |
| Theoretical pI
| 6.72 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dedicator of cytokinesis protein 6
MAASERRAFAHKINRTVAAEVRKQVSRERSGSPHSSRRCSSSLGVPLTEVVEPLDFEDVL
LSRPPDAEPGPLRDLVEFPADDLELLLQPRECRTTEPGIPKDEKLDAQVRAAVEMYIEDW
VIVHRRYQYLSAAYSPVTTDTQRERQKGLPRQVFEQDASGDERSGPEDSNDSRRGSGSPE
DTPRSSGASSIFDLRNLAADSLLPSLLERAAPEDVDRRNETLRRQHRPPALLTLYPAPDE
DEAVERCSRPEPPREHFGQRILVKCLSLKFEIEIEPIFGILALYDVREKKKISENFYFDL
NSDSMKGLLRAHGTHPAISTLARSAIFSVTYPSPDIFLVIKLEKVLQQGDISECCEPYMV
LKEVDTAKNKEKLEKLRLAAEQFCTRLGRYRMPFAWTAVHLANIVSSAGQLDRDSDSEGE
RRPAWTDRRRRGPQDRASSGDDACSFSGFRPATLTVTNFFKQEAERLSDEDLFKFLADMR
RPSSLLRRLRPVTAQLKIDISPAPENPHFCLSPELLHIKPYPDPRGRPTKEILEFPAREV
YAPHTSYRNLLYVYPHSLNFSSRQGSVRNLAVRVQYMTGEDPSQALPVIFGKSSCSEFTR
EAFTPVVYHNKSPEFYEEFKLHLPACVTENHHLLFTFYHVSCQPRPGTALETPVGFTWIP
LLQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDGHKGVFSVELTAVSSVHPQ
DPYLDKFFTLVHVLEEGAFPFRLKDTVLSEGNVEQELRASLAALRLASPEPLVAFSHHVL
DKLVRLVIRPPIISGQIVNLGRGAFEAMAHVVSLVHRSLEAAQDARGHCPQLAAYVHYAF
RLPGTEPSLPDGAPPVTVQAATLARGSGRPASLYLARSKSISSSNPDLAVAPGSVDDEVS
RILASKLLHEELALQWVVSSSAVREAILQHAWFFFQLMVKSMALHLLLGQRLDTPRKLRF
PGRFLDDITALVGSVGLEVITRVHKDVELAEHLNASLAFFLSDLLSLVDRGFVFSLVRAH
YKQVATRLQSSPNPAALLTLRMEFTRILCSHEHYVTLNLPCCPLSPPASPSPSVSSTTSQ
SSTFSSQAPDPKVTSMFELSGPFRQQHFLAGLLLTELALALEPEAEGAFLLHKKAISAVH
SLLCGHDTDPRYAEATVKARVAELYLPLLSIARDTLPRLHDFAEGPGQRSRLASMLDSDT
EGEGDIAGTINPSVAMAIAGGPLAPGSRASISQGPPTASRAGCALSAESSRTLLACVLWV
LKNTEPALLQRWATDLTLPQLGRLLDLLYLCLAAFEYKGKKAFERINSLTFKKSLDMKAR
LEEAILGTIGARQEMVRRSRERSPFGNPENVRWRKSVTHWKQTSDRVDKTKDEMEHEALV
EGNLATEASLVVLDTLEIIVQTVMLSEARESVLGAVLKVVLYSLGSAQSALFLQHGLATQ
RALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRTHASASLYLLMRQNFEIGHNFA
RVKMQVTMSLSSLVGTTQNFSEEHLRRSLKTILTYAEEDMGLRDSTFAEQVQDLMFNLHM
ILTDTVKMKEHQEDPEMLIDLMYRIARGYQGSPDLRLTWLQNMAGKHAELGNHAEAAQCM
VHAAALVAEYLALLEDHRHLPVGCVSFQNISSNVLEESAISDDILSPDEEGFCSGKHFTE
LGLVGLLEQAAGYFTMGGLYEAVNEVYKNLIPILEAHRDYKKLAAVHGKLQEAFTKIMHQ
SSGWERVFGTYFRVGFYGAHFGDLDEQEFVYKEPSITKLAEISHRLEEFYTERFGDDVVE
IIKDSNPVDKSKLDSQKAYIQITYVEPYFDTYELKDRVTYFDRNYGLRTFLFCTPFTPDG
RAHGELPEQHKRKTLLSTDHAFPYIKTRIRVCHREETVLTPVEVAIEDMQKKTRELAFAT
EQDPPDAKMLQMVLQGSVGPTVNQGPLEVAQVFLAEIPEDPKLFRHHNKLRLCFKDFCKK
CEDALRKNKALIGPDQKEYHRELERNYCRLREALQPLLTQRLPQLMAPTPPGLRNSLNRA
SFRKADL
|
| External Links |
|---|
| GenBank ID Protein
| 157426887 |
| UniProtKB/Swiss-Prot ID
| Q96HP0 |
| UniProtKB/Swiss-Prot Entry Name
| DOCK6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020812.2 |
| GeneCard ID
| DOCK6 |
| GenAtlas ID
| DOCK6 |
| HGNC ID
| HGNC:19189 |
| References |
|---|
| General References
| Not Available |