| Identification |
|---|
| HMDB Protein ID
| CDBP03570 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dedicator of cytokinesis protein 5 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| DOCK5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP |
| GO Classification
|
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| enzyme regulator activity |
| protein binding |
| gtpase binding |
| enzyme binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p21.2 |
| SNPs
| DOCK5 |
| Gene Sequence
|
>5613 bp
ATGGCCCGCTGGATCCCGACCAAGAGGCAGAAGTACGGGGTTGCGATCTATAACTACAAT
GCTTCTCAAGATGTGGAGCTCTCCTTGCAGATCGGTGACACAGTTCACATCCTGGAGATG
TACGAGGGTTGGTACAGAGGATATACCCTCCAAAATAAATCTAAAAAGGGCATTTTCCCT
GAAACATATATCCATTTGAAAGAGGCAACTGTGGAAGACCTGGGGCAGCATGAAACCGTG
ATTCCTGGCGAGCTCCCCCTGGTGCAGGAGCTCACGTCCACTCTGCGAGAATGGGCTGTC
ATCTGGCGAAAGCTCTACGTGAACAACAAGCTCACCCTCTTCCGCCAGCTGCAGCAGATG
ACGTACAGCCTGATCGAGTGGCGGTCCCAGATCCTGTCTGGGACGCTCCCCAAGGATGAA
CTGGCAGAGCTCAAGAAGAAAGTCACAGCCAAAATTGATCATGGGAACAGAATGCTGGGG
TTAGATCTGGTGGTGCGAGATGACAATGGGAACATCCTAGACCCTGACGAAACCAGCACC
ATTGCCCTCTTCAAGGCCCATGAGGTGGCCTCCAAAAGGATTGAGGAAAAGATCCAAGAA
GAGAAGTCAATCCTGCAGAACCTCGATTTGCGGGGCCAGTCCATCTTCAGTACCATCCAC
ACCTATGGCCTCTATGTGAACTTCAAGAACTTTGTCTGCAACATCGGGGAAGATGCAGAG
TTGTTTATGGCCCTCTACGACCCAGACCAGTCCACTTTTATCAGTGAGAACTATCTAATT
CGTTGGGGCAGTAACGGGATGCCCAAGGAAATAGAGAAGCTCAATAACCTCCAAGCAGTG
TTTACAGACCTTAGCAGCATGGACCTCATCCGGCCCCGCGTCAGCCTTGTGTGCCAGATT
GTCCGCGTGGGCCATATGGAGCTGAAGGAAGGCAAGAAGCACACCTGTGGACTCCGAAGA
CCTTTTGGAGTGGCAGTGATGGATATTACTGATATCATACATGGGAAGGTGGATGATGAA
GAAAAGCAGCATTTTATTCCCTTTCAGCAAATTGCGATGGAAACCTACATCCGCCAGAGG
CAGCTCATCATGTCGCCTTTGATAACATCACACGTGATTGGGGAGAATGAGCCACTCACT
TCAGTCTTGAATAAAGTGATTGCAGCAAAGGAAGTGAATCACAAAGGGCAAGGCCTTTGG
GTATCCTTGAAGCTCTTGCCCGGTGACCTCACCCAGGTTCAGAAGAATTTTTCACACTTG
GTTGATAGATCAACAGCAATAGCCCGGAAGATGGGCTTTCCTGAAATCATACTGCCAGGA
GATGTTCGGAATGACATTTATGTCACCCTGATCCACGGTGAGTTTGACAAAGGGAAGAAG
AAGACGCCAAAGAATGTGGAGGTGACGATGTCTGTGCACGATGAGGAGGGCAAGCTCTTG
GAGAAAGCAATTCACCCTGGTGCTGGATATGAAGGCATTTCAGAATACAAATCAGTAGTC
TATTACCAAGTCAAGCAGCCCTGTTGGTATGAGACTGTCAAGGTATCCATTGCTATAGAA
GAAGTCACACGCTGTCATATAAGATTTACCTTCCGACACAGGTCATCTCAGGAAACCAGA
GATAAATCGGAGCGAGCATTTGGGGTGGCCTTCGTGAAGCTGATGAACCCGGATGGCACC
ACTCTGCAGGATGGGAGGCACGATCTGGTGGTTTATAAGGGTGACAACAAAAAAATGGAA
GATGCTAAATTCTACCTGACCCTGCCTGGAACCAAGATGGAGATGGAAGAAAAAGAGCTT
CAAGCATCCAAAAACCTGGTCACCTTCACCCCAAGCAAGGATAGCACTAAAGACAGCTTT
CAGATTGCCACCCTCATCTGCTCCACAAAGCTCACCCAGAATGTTGACCTGTTAGGCTTG
TTAAATTGGCGTTCCAACTCCCAGAACATTAAACACAACCTAAAGAAGTTAATGGAAGTG
GATGGAGGAGAGATTGTTAAGTTTTTGCAAGATACACTAGATGCACTCTTTAACATAATG
ATGGAAATGTCAGACAGTGAAACCTATGACTTCCTTGTGTTTGACGCACTGGTATTTATT
ATTTCACTGATAGGAGACATCAAGTTCCAGCATTTTAATCCTGTACTTGAAACCTACATT
TACAAGCACTTCAGCGCCACTTTGGCATATGTGAAACTCTCCAAGGTACTGAACTTCTAT
GTGGCTAATGCAGATGACTCCAGCAAGACTGAACTGCTTTTTGCTGCGTTGAAAGCCTTG
AAGTACTTGTTTAGATTCATCATCCAATCCCGAGTGCTCTACTTGAGATTTTATGGGCAG
AGCAAAGATGGAGATGAGTTTAATAATTCAATTCGCCAGTTATTTCTTGCTTTCAATATG
CTGATGGACAGGCCTCTGGAGGAAGCCGTCAAGATCAAGGGGGCAGCTTTGAAGTACCTT
CCTAGCATAATTAATGATGTCAAACTTGTATTTGATCCTGTTGAGCTCAGCGTGCTCTTC
TGCAAATTCATTCAAAGCATTCCTGACAACCAGCTGGTTCGGCAGAAACTTAACTGCATG
ACCAAGATAGTAGAGAGCACTCTTTTTCGACAGTCAGAGTGCAGAGAAGTGCTGCTGCCA
CTGCTGACAGACCAGCTCAGCGGCCAGTTAGATGACAACTCCAACAAGCCTGACCACGAG
GCAAGCTCGCAGCTTCTGAGCAACATCCTGGAGGTGCTGGACAGGAAGGATGTGGGTGCC
ACTGCGGTGCACATTCAGCTTATAATGGAACGGCTGCTGAGAAGGATCAACCGGACAGTG
ATTGGGATGAACCGGCAGTCTCCCCACATCGGGAGTTTTGTGGCTTGCATGATTGCCCTG
CTGCAGCAAATGGACGACAGCCACTATAGCCACTACATCAGCACTTTCAAAACCAGACAA
GACATCATCGACTTCCTCATGGAAACTTTTATCATGTTCAAGGACCTGATTGGAAAGAAT
GTCTATGCCAAAGATTGGATGGTGATGAATATGACTCAAAACAGGGTTTTTCTCCGTGCT
ATAAATCAGTTTGCTGAAGTTCTCACAAGATTCTTCATGGATCAGGCAAGCTTTGAACTT
CAGCTCTGGAACAATTACTTCCATTTGGCAGTTGCATTTCTCACCCATGAGTCCCTTCAG
CTTGAAACCTTCTCACAAGCCAAGCGCAACAAAATTGTTAAAAAATATGGGGACATGAGA
AAGGAAATCGGCTTTAGAATCCGGGACATGTGGTATAACCTGGGTCCCCACAAAATCAAA
TTCATCCCATCCATGGTGGGTCCCATTCTGGAGGTCACTCTGACCCCTGAAGTAGAGCTC
CGGAAAGCCACAATCCCCATTTTCTTTGATATGATGCAGTGTGAGTTCAATTTCAGTGGA
AATGGCAATTTCCATATGTTTGAGAATGAGCTGATCACAAAGCTGGACCAGGAGGTAGAA
GGGGGCAGAGGAGACGAACAATACAAGGTTCTTCTGGAAAAACTGCTCCTAGAACATTGC
CGGAAACACAAATACCTCTCCAGCTCTGGGGAGGTCTTCGCCCTCCTGGTCAGCAGCCTC
TTAGAGAACCTGCTGGACTATAGAACCATCATCATGCAAGATGAGAGCAAGGAGAACCGT
ATGAGCTGCACTGTGAACGTGCTGAACTTTTATAAAGAAAAGAAGAGAGAGGACATATAC
ATAAGATATCTGTACAAGCTTCGAGATTTGCACCGAGACTGTGAGAACTACACAGAAGCT
GCCTACACGCTTCTCTTGCACGCTGAGCTTCTGCAGTGGTCTGACAAGCCCTGTGTGCCT
CATTTGCTTCAGAAGGACAGTTACTATGTTTATACCCAGCAAGAGCTTAAAGAGAAGCTG
TATCAAGAAATCATATCATATTTCGACAAAGGCAAAATGTGGGAGAAGGCCATCAAGCTG
AGCAAAGAGTTGGCTGAGACTTACGAAAGCAAAGTATTTGACTACGAGGGCCTTGGCAAC
CTCCTGAAAAAAAGGGCCTCATTTTATGAGAACATCATTAAGGCAATGAGGCCTCAGCCT
GAATACTTTGCTGTTGGATACTATGGACAGGGCTTTCCTTCTTTCCTACGGAATAAAATC
TTCATCTATCGGGGAAAGGAGTATGAGAGGCGAGAGGACTTCAGCCTGAGGTTGTTAACC
CAGTTCCCCAATGCGGAGAAGATGACCAGTACCACGCCTCCTGGGGAAGACATCAAGTCG
TCCCCCAAGCAGTACATGCAGTGCTTCACTGTAAAGCCAGTGATGAGCTTGCCGCCCAGC
TACAAGGATAAACCTGTTCCAGAGCAGATCTTAAACTACTACAGAGCCAATGAAGTGCAG
CAGTTCAGATACTCCCGGCCGTTCCGGAAAGGAGAAAAGGATCCAGACAATGAATTTGCT
ACGATGTGGATTGAACGGACCACGTATACGACTGCATATACCTTTCCTGGGATTCTCAAG
TGGTTTGAAGTCAAACAGATTTCAACAGAAGAGATCAGTCCTCTGGAGAATGCCATCGAA
ACCATGGAGCTGACCAACGAGAGGATCAGCAACTGTGTTCAGCAGCATGCCTGGGACCGG
TCCCTCTCTGTGCACCCTCTCTCCATGCTGCTCAGTGGCATCGTGGACCCGGCCGTCATG
GGGGGCTTCTCCAACTATGAAAAGGCTTTTTTTACAGAAAAGTACTTGCAGGAGCATCCT
GAAGACCAGGAGAAGGTTGAGCTGCTAAAGCGACTAATAGCATTACAGATGCCCCTGCTA
ACAGAAGGGATCCGCATCCATGGGGAGAAACTCACAGAGCAGCTGAAGCCGCTGCATGAG
CGGTTGTCTTCTTGCTTCCGGGAACTCAAGGAGAAAGTAGAAAAGCACTATGGGGTTATA
ACACTGCCACCCAACTTGACGGAGAGGAAGCAAAGCCGCACGGGGTCTATTGTGCTCCCC
TACATCATGTCTTCCACTCTGCGGAGGTTGTCCATCACCTCAGTCACTTCCTCTGTGGTT
TCCACCTCTTCAAACTCGTCTGACAATGCTCCTTCCAGACCGGGATCTGATGGCTCAATC
TTGGAGCCACTTTTGGAGCGCAGGGCCTCGTCAGGTGCCAGAGTTGAAGATCTGTCCCTT
AGAGAGGAGAACAGCGAGAACCGGATCAGCAAGTTTAAGAGAAAAGACTGGAGTCTGAGC
AAGTCCCAGGTCATTGCAGAGAAAGCACCAGAACCCGATTTGATGAGCCCAACCAGAAAA
GCACAAAGGCCAAAGAGTCTCCAGTTGATGGATAATCGGCTATCACCATTTCACGGTTCT
TCACCTCCTCAGTCAACACCCTTGAGCCCACCTCCACTCACTCCCAAAGCCACCAGGACC
CTAAGCTCCCCATCGTTGCAGACAGATGGAATCGCGGCCACTCCTGTCCCACCTCCACCT
CCCCCCAAAAGCAAGCCCTATGAAGGCAGCCAGAGGAACTCCACTGAGCTCGCTCCCCCA
CTGCCTGTCCGAAGAGAAGCCAAAGCACCACCCCCTCCACCTCCAAAGGCTCGGAAGTCT
GGCATCCCTACTTCCGAGCCTGGATCCCAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1870 |
| Molecular Weight
| 215306.9 |
| Theoretical pI
| 8.08 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dedicator of cytokinesis protein 5
MARWIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGWYRGYTLQNKSKKGIFP
ETYIHLKEATVEDLGQHETVIPGELPLVQELTSTLREWAVIWRKLYVNNKLTLFRQLQQM
TYSLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNILDPDETST
IALFKAHEVASKRIEEKIQEEKSILQNLDLRGQSIFSTIHTYGLYVNFKNFVCNIGEDAE
LFMALYDPDQSTFISENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSMDLIRPRVSLVCQI
VRVGHMELKEGKKHTCGLRRPFGVAVMDITDIIHGKVDDEEKQHFIPFQQIAMETYIRQR
QLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHL
VDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGKLL
EKAIHPGAGYEGISEYKSVVYYQVKQPCWYETVKVSIAIEEVTRCHIRFTFRHRSSQETR
DKSERAFGVAFVKLMNPDGTTLQDGRHDLVVYKGDNKKMEDAKFYLTLPGTKMEMEEKEL
QASKNLVTFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEV
DGGEIVKFLQDTLDALFNIMMEMSDSETYDFLVFDALVFIISLIGDIKFQHFNPVLETYI
YKHFSATLAYVKLSKVLNFYVANADDSSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQ
SKDGDEFNNSIRQLFLAFNMLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPVELSVLF
CKFIQSIPDNQLVRQKLNCMTKIVESTLFRQSECREVLLPLLTDQLSGQLDDNSNKPDHE
ASSQLLSNILEVLDRKDVGATAVHIQLIMERLLRRINRTVIGMNRQSPHIGSFVACMIAL
LQQMDDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRA
INQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSQAKRNKIVKKYGDMR
KEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNFSG
NGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLSSSGEVFALLVSSL
LENLLDYRTIIMQDESKENRMSCTVNVLNFYKEKKREDIYIRYLYKLRDLHRDCENYTEA
AYTLLLHAELLQWSDKPCVPHLLQKDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKL
SKELAETYESKVFDYEGLGNLLKKRASFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKI
FIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYMQCFTVKPVMSLPPS
YKDKPVPEQILNYYRANEVQQFRYSRPFRKGEKDPDNEFATMWIERTTYTTAYTFPGILK
WFEVKQISTEEISPLENAIETMELTNERISNCVQQHAWDRSLSVHPLSMLLSGIVDPAVM
GGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQMPLLTEGIRIHGEKLTEQLKPLHE
RLSSCFRELKEKVEKHYGVITLPPNLTERKQSRTGSIVLPYIMSSTLRRLSITSVTSSVV
STSSNSSDNAPSRPGSDGSILEPLLERRASSGARVEDLSLREENSENRISKFKRKDWSLS
KSQVIAEKAPEPDLMSPTRKAQRPKSLQLMDNRLSPFHGSSPPQSTPLSPPPLTPKATRT
LSSPSLQTDGIAATPVPPPPPPKSKPYEGSQRNSTELAPPLPVRREAKAPPPPPPKARKS
GIPTSEPGSQ
|
| External Links |
|---|
| GenBank ID Protein
| 117553586 |
| UniProtKB/Swiss-Prot ID
| Q9H7D0 |
| UniProtKB/Swiss-Prot Entry Name
| DOCK5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_024940.6 |
| GeneCard ID
| DOCK5 |
| GenAtlas ID
| DOCK5 |
| HGNC ID
| HGNC:23476 |
| References |
|---|
| General References
| Not Available |