| Identification |
|---|
| HMDB Protein ID
| CDBP03564 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dedicator of cytokinesis protein 10 |
| Description
| Not Available |
| Synonyms
|
- Zizimin-3
|
| Gene Name
| DOCK10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanyl-nucleotide exchange factor activity |
| Specific Function
| Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP |
| GO Classification
|
| Function |
| guanyl-nucleotide exchange factor activity |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| enzyme regulator activity |
| protein binding |
| gtpase binding |
| enzyme binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q36.2 |
| SNPs
| DOCK10 |
| Gene Sequence
|
>6561 bp
ATGGCCGGTGAGCGGACCCGCAGGTTCACCCGGAGCCTGTTGAGACCTGGGCAGGCGGCC
GAGCTCCGGCACAGCGCCGCGTCCGCCGCCGCGGTGGCAGTCAGCAGCCGGCAGCAGCAG
CGGCAAGAAAAGCCTAGGCTTCTCGAGCCTTTGGATTATGAGACTGTCATTGAAGAACTT
GAAAAGACCTACCGGAATGATCCTCTTCAAGATCTCTTGTTCTTCCCCAGTGATGACTTT
TCAGCAGCCACAGTTTCCTGGGATATCCGCACGTTGTACTCAACAGTACCTGAAGATGCA
GAGCACAAGGCAGAAAATTTACTGGTTAAGGAGGCTTGTAAATTTTATAGTTCCCAGTGG
CATGTGGTAAACTACAAATATGAACAATATTCTGGAGACATTCGACAGCTACCCCGAGCA
GAATACAAACCAGAGAAGCTTCCTTCACATTCCTTTGAGATTGACCATGAAGATGCTGAT
AAGGATGAAGATACCACTTCCCACTCGTCTTCCAAGGGGGGTGGAGGAGCGGGAGGAACT
GGTGTTTTCAAGTCCGGCTGGCTCTACAAGGGGAATTTTAACAGCACCGTGAACAACACC
GTTACTGTTCGGTCATTCAAAAAGCGCTACTTCCAGCTGACTCAGTTACCAGATAACTCC
TACATTATGAACTTTTACAAAGATGAGAAAATATCCAAAGAACCCAAAGGATGCATCTTT
TTGGATTCCTGTACAGGAGTGGTGCAGAATAACAGACTAAGAAAATATGCCTTTGAATTG
AAAATGAATGATCTGACCTATTTTGTGCTGGCAGCTGAAACAGAGTCAGATATGGATGAA
TGGATCCACACCCTCAACCGCATTCTGCAAATCAGTCCTGAGGGGCCCCTCCAAGGGAGG
AGGAGCACAGAGCTCACTGATCTGGGTCTGGATTCGCTGGATAATTCTGTAACTTGTGAA
TGCACGCCAGAGGAAACAGATTCTTCAGAGAACAACCTACACGCAGACTTTGCAAAGTAC
CTCACAGAAACAGAAGATACTGTAAAAACAACTCGAAACATGGAGAGGCTAAATCTGTTC
TCTCTAGATCCAGACATAGATACCTTGAAACTTCAAAAAAAAGATCTCTTGGAACCTGAG
TCTGTGATCAAACCATTTGAAGAAAAAGCTGCCAAGAGAATCATGATCATCTGTAAAGCC
CTCAACTCAAATCTTCAGGGATGTGTTACGGAGAATGAAAATGATCCGATAACGAATATT
GAGCCTTTTTTTGTGAGTGTGGCACTTTATGACCTCAGAGACAGCAGGAAGATTTCTGCT
GATTTTCATGTGGATCTAAACCATGCTGCTGTCAGACAGATGCTCTTGGGGGCTTCTGTG
GCTTTGGAAAATGGCAACATCGACACCATCACTCCAAGACAATCAGAAGAACCTCACATC
AAGGGACTTCCAGAGGAATGGCTAAAATTTCCAAAGCAGGCTGTATTTTCTGTAAGCAAT
CCACATTCTGAAATTGTTTTGGTGGCCAAAATCGAAAAAGTCTTGATGGGAAACATTGCA
AGTGGTGCCGAACCTTATATTAAGAACCCAGACTCCAACAAGTATGCACAAAAGATACTA
AAATCCAACAGACAATTCTGCAGCAAATTGGGAAAATACCGTATGCCTTTTGCTTGGGCA
GTAAGATCAGTATTTAAGGACAACCAGGGAAATGTGGACAGAGACTCAAGATTTTCACCA
TTGTTTAGACAAGAAAGTAGCAAGATTTCAACTGAGGACCTAGTTAAACTAGTATCAGAT
TATAGAAGGGCCGACAGAATAAGCAAAATGCAGACCATTCCTGGAAGCCTGGATATTGCT
GTTGACAACGTTCCCTTGGAGCATCCAAATTGTGTAACATCGTCCTTTATCCCTGTCAAG
CCTTTCAACATGATGGCTCAAACAGAACCCACAGTGGAGGTGGAAGAATTTGTTTACGAT
TCAACAAAGTATTGTCGGCCTTACAGAGTATATAAAAATCAAATTTATATTTACCCCAAA
CACCTCAAGTATGATAGCCAGAAATGCTTCAACAAGGCACGGAATATAACTGTGTGCATT
GAATTCAAAAATTCAGATGAAGAAAGTGCCAAGCCCCTGAAGTGTATTTATGGAAAACCT
GGAGGGCCCCTCTTCACCTCAGCCGCCTACACAGCAGTTCTGCACCACTCTCAGAATCCG
GATTTCTCAGATGAGGTGAAAATTGAGCTACCAACACAACTCCATGAGAAACACCATATT
TTGTTTTCTTTTTATCACGTCACCTGTGACATCAATGCAAAAGCTAATGCCAAAAAGAAG
GAGGCTCTGGAAACGTCAGTTGGATATGCTTGGCTTCCTCTGATGAAACACGATCAGATA
GCTTCTCAAGAGTACAACATCCCAATAGCAACAAGTCTGCCTCCTAATTATTTAAGCTTT
CAAGATTCTGCAAGTGGAAAGCATGGTGGGAGTGACATTAAATGGGTTGATGGTGGCAAA
CCACTTTTCAAAGTGTCGACATTTGTTGTATCAACAGTAAATACTCAGGATCCACATGTG
AATGCATTTTTCCAAGAGTGCCAAAAAAGAGAGAAAGATATGTCTCAGTCACCTACCTCA
AATTTCATCCGCTCTTGTAAGAACTTATTGAATGTGGAAAAGATTCATGCAATCATGAGT
TTTCTGCCTATAATTTTGAATCAGCTCTTCAAAGTTCTGGTACAGAATGAGGAAGATGAA
ATAACTACAACTGTCACCAGGGTTCTGACCGACATTGTGGCCAAGTGCCATGAGGAGCAG
CTGGATCATTCTGTCCAGTCATATATTAAGTTCGTGTTCAAGACCAGGGCATGCAAGGAG
AGGACTGTACATGAGGAACTGGCTAAAAATGTGACTGGTCTTTTGAAATCAAATGACTCA
ACAACAGTAAAGCATGTCCTAAAGCATTCCTGGTTCTTCTTTGCAATTATCCTAAAATCG
ATGGCACAGCACTTGATTGACACAAATAAAATCCAGCTTCCCCGGCCTCAGAGATTTCCT
GAATCTTACCAAAATGAATTGGACAATCTTGTCATGGTCCTATCCGACCATGTGATTTGG
AAATACAAGGATGCACTTGAAGAAACAAGAAGGGCAAACCACAGCGTTGCCAGATTTCTC
AAGCGCTGCTTTACATTTATGGACCGAGGGTATGTGTTTAAGATGGTCAACAATTACATC
AGCATGTTCTCCTCCGGTGACCTTAAGACCTTGTGCCAGTATAAATTTGATTTTCTTCAA
GAAGTATGTCAACATGAACACTTTATCCCTTTGTGTCTGCCCATAAGATCAGCAAACATT
CCAGATCCTTTGACACCTTCAGAATCGACTCAAGAGTTACATGCATCAGATATGCCTGAA
TATTCAGTCACAAATGAATTTTGTCGCAAACACTTCTTAATCGGAATTCTGCTCCGAGAA
GTTGGCTTTGCCCTGCAGGAAGACCAAGATGTCAGACACTTAGCTTTAGCTGTCCTAAAA
AATCTAATGGCTAAGCATTCATTTGATGATCGATACAGAGAGCCAAGAAAGCAGGCCCAG
ATAGCAAGTTTATACATGCCCCTGTACGGCATGCTCCTGGACAATATGCCAAGGATTTAT
CTGAAGGACCTGTATCCTTTTACTGTCAATACATCTAATCAGGGGTCTAGAGATGATCTA
AGCACCAATGGAGGATTTCAAAGCCAGACAGCTATCAAACATGCAAACTCTGTGGATACA
TCATTTTCTAAAGATGTTTTAAATTCCATAGCAGCATTTTCATCAATAGCTATTTCTACA
GTAAACCATGCTGACTCCAGAGCATCTTTAGCAAGTCTTGACTCCAATCCAAGTACCAAT
GAGAAGAGCAGTGAGAAGACGGACAACTGTGAAAAGATCCCAAGACCCTTGTCTTTGATT
GGCTCAACTCTTCGATTTGACAAGTTAGATCAAGCAGAAACCAGGAGTCTCCTGATGTGT
TTTCTTCACATTATGAAAACGATTTCGTACGAGACTCTGATTGCCTACTGGCAGAGAGCT
CCCAGCCCAGAGGTGTCCGACTTCTTCAGCATCTTGGACGTTTGTCTTCAAAATTTCAGA
TACCTAGGAAAACGCAACATAATAAGAAAAATTGCTGCTGCATTTAAATTTGTGCAGTCC
ACCCAGAACAATGGAACTCTCAAAGGATCCAATCCTTCCTGCCAGACATCAGGTCTCTTG
TCACAATGGATGCACTCCACTTCCAGTCATGAAGGCCATAAGCAGCACAGATCACAAACT
TTACCTATAATTCGAGGCAAAAATGCACTTTCTAACCCCAAACTCTTACAGATGTTAGAC
AATACCATGACCAGCAACTCCAATGAAATAGACATCGTGCATCATGTAGACACTGAGGCC
AATATAGCTACGGAGGTTTGCCTCACTATTCTGGACCTGTTATCCCTCTTCACACAGACT
CATCAGAGACAACTCCAACAATGTGACTGTCAAAATTCATTGATGAAAAGGGTCTTTGAT
ACCTACATGCTCTTTTTCCAAGTCAATCAGTCAGCCACAGCGCTGAAGCATGTGTTTGCC
TCCTTGAGACTGTTTGTATGCAAGTTTCCTTCAGCGTTCTTTCAAGGGCCTGCTGACCTC
TGTGGATCATTCTGTTACGAAGTCCTAAAATGCTGTAACCACAGGTCACGGTCAACTCAG
ACAGAAGCCTCAGCCCTTCTGTACTTTTTCATGAGGAAGAATTTTGAATTTAACAAGCAG
AAGTCAATTGTCCGGTCCCACTTACAACTCATCAAAGCTGTGAGCCAGTTAATAGCCGAT
GCTGGGATTGGAGGCTCTCGGTTTCAACATTCGCTTGCAATTACCAATAATTTCGCCAAT
GGAGATAAGCAAATGAAAAACAGCAATTTCCCAGCAGAGGTGAAGGACCTGACTAAGCGT
ATAAGGACTGTTTTGATGGCCACAGCTCAGATGAAGGAGCACGAGAAGGACCCCGAGATG
CTGGTGGATCTCCAGTACAGCCTGGCAAACTCCTACGCAAGCACTCCTGAACTACGCAGG
ACCTGGCTGGAAAGTATGGCCAAGATTCATGCCAGAAACGGAGATTTATCTGAGGCTGCC
ATGTGTTACATCCATATTGCTGCTCTCATTGCAGAGTATCTGAAAAGAAAGGGTTACTGG
AAAGTGGAAAAGATTTGCACAGCATCCCTGCTCTCGGAGGATACCCACCCCTGTGATAGC
AACTCATTACTAACAACTCCCAGTGGAGGAAGCATGTTCTCTATGGGATGGCCAGCTTTT
TTGAGCATTACACCAAACATTAAGGAAGAAGGAGCGATGAAAGAGGATTCTGGAATGCAA
GATACACCATACAATGAGAATATCCTGGTGGAGCAGCTATACATGTGTGTGGAGTTTCTC
TGGAAGTCTGAGCGATATGAACTCATTGCTGATGTCAACAAGCCCATCATTGCTGTCTTT
GAGAAACAACGAGACTTCAAAAAATTGTCAGATCTCTACTACGACATTCATCGGTCATAT
CTGAAAGTGGCAGAGGTGGTGAATTCGGAGAAGCGGCTGTTTGGTCGCTACTATCGTGTG
GCATTTTATGGGCAGGGCTTTTTTGAAGAAGAAGAAGGTAAAGAGTATATTTATAAAGAG
CCTAAGCTGACAGGTCTGTCCGAGATTTCCCAAAGATTACTCAAGCTCTATGCAGATAAA
TTTGGAGCAGACAATGTGAAGATAATCCAGGATTCCAACAAGGTAAACCCCAAGGATTTG
GACCCCAAATATGCCTACATCCAGGTGACCTATGTGACGCCGTTCTTTGAGGAAAAGGAA
ATCGAAGACCGGAAGACAGATTTCGAAATGCACCACAACATCAACCGCTTTGTCTTCGAG
ACACCCTTCACGCTGTCGGGCAAGAAGCACGGTGGGGTGGCGGAGCAGTGCAAGCGGCGG
ACGATCCTGACAACGAGTCACCTGTTCCCCTACGTGAAGAAGAGAATACAAGTAATTAGC
CAATCGAGCACAGAACTGAATCCAATTGAAGTGGCAATTGACGAGATGTCCAAGAAGGTT
TCTGAGCTTAATCAGCTTTGCACAATGGAAGAAGTGGACATGATCAGACTGCAGCTCAAA
CTGCAAGGAAGTGTCAGCGTGAAGGTTAATGCTGGGCCAATGGCCTATGCACGAGCTTTT
CTTGAAGAAACCAATGCAAAGAAGTACCCTGACAACCAAGTAAAGCTTTTGAAGGAGATC
TTCAGGCAATTTGCAGATGCATGTGGGCAGGCCCTTGACGTGAATGAGCGCCTCATCAAA
GAGGACCAGCTGGAGTACCAGGAAGAACTGAGGTCCCACTACAAGGACATGCTCAGCGAA
CTCTCCACAGTCATGAATGAGCAGATTACGGGCAGGGACGACCTGTCAAAGCGCGGAGTG
GACCAAACCTGCACTCGAGTAATTAGCAAAGCAACTCCGGCCCTACCCACGGTCTCCATC
TCATCTAGTGCTGAAGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 2183 |
| Molecular Weight
| 249310.2 |
| Theoretical pI
| 6.93 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dedicator of cytokinesis protein 10
MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLEPLDYETVIEEL
EKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQW
HVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDEDTTSHSSSKGGGGAGGT
GVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIF
LDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGR
RSTELTDLGLDSLDNSVTCECTPEETDSSENNLHADFAKYLTETEDTVKTTRNMERLNLF
SLDPDIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIICKALNSNLQGCVTENENDPITNI
EPFFVSVALYDLRDSRKISADFHVDLNHAAVRQMLLGASVALENGNIDTITPRQSEEPHI
KGLPEEWLKFPKQAVFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKIL
KSNRQFCSKLGKYRMPFAWAVRYVFKDNQGNVDRDSRFSPLFRQESSKISTEDLVKLVSD
YRRADRISKMQTIPGSLDIAVDNVPLEHPDCVTSSFIPVKPFNMMAQTEPTVEVEEFVYD
STKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKP
GGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKK
EALETSVGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSASHGGSDIKWVDGGKPL
FKVSTFVVSTVNTQDPHVNAFFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAIMSFL
PIILNQLFKVLVQNEEDEITTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTRACKERT
VHEELAKNVTGLLKSNDSTTVKHVLEHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFPES
YQNELDNLVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYISM
FSSGDFQTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPEYS
VTNEFCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYRERKQAQIAS
LYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDTSFS
KDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKVPRPLSLIGST
LRFDKLDQAETRSLLMCFLHIMKTISDETLIAYWQRAPSPEVSDFFSILEVCLQNFRYLG
KRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHSTSSHEGHKQHRSQTLPI
IRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQTHQR
QLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCGS
FCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGI
GGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVD
LQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKVE
KICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTP
YNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKV
AEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGA
DNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPF
TLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSKKVSEL
NQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQ
FADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSTVMNEQITGRDDLSKRGVDQT
CTRVISKATPALPTVSISSSAEV
|
| External Links |
|---|
| GenBank ID Protein
| 154146189 |
| UniProtKB/Swiss-Prot ID
| Q96BY6 |
| UniProtKB/Swiss-Prot Entry Name
| DOC10_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| DOCK10 |
| GenAtlas ID
| DOCK10 |
| HGNC ID
| HGNC:23479 |
| References |
|---|
| General References
| Not Available |