| Identification |
|---|
| HMDB Protein ID
| CDBP03557 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein |
| Description
| Not Available |
| Synonyms
|
- DEP domain-containing protein 2
- P-Rex2
- PtdIns(3,4,5)-dependent Rac exchanger 2
|
| Gene Name
| PREX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular signaling pathway |
| Specific Function
| Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| guanyl-nucleotide exchange factor activity |
| small gtpase regulator activity |
| binding |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| protein binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q13.2 |
| SNPs
| PREX2 |
| Gene Sequence
|
>4821 bp
ATGAGCGAGGACAGCCGCGGAGACAGCCGCGCCGAGAGCGCCAAGGACCTGGAGAAGCAG
CTTCGCCTGCGCGTGTGCGTGCTCAGCGAGCTCCAGAAGACCGAGCGGGACTATGTGGGC
ACGCTGGAGTTCCTGGTGTCGGCATTCTTACACAGAATGAACCAGTGTGCAGCATCAAAA
GTTGACAAAAATGTGACAGAAGAAACAGTGAAGATGTTGTTCTCAAACATTGAAGACATC
CTTGCAGTACATAAAGAATTCTTAAAAGTCGTGGAAGAATGCTTACACCCCGAACCTAAT
GCTCAACAAGAAGTGGGAACCTGCTTTCTTCACTTTAAAGACAAGTTTCGTATCTATGAT
GAATATTGTAGTAACCATGAGAAGGCACAAAAATTACTTCTTGAACTCAACAAAATAAGA
ACAATCCGGACATTTCTTTTGAACTGCATGCTGCTTGGAGGACGGAAGAACACAGATGTT
CCCTTGGAAGGATATTTAGTAACACCAATACAAAGAATATGCAAGTACCCTCTTATTTTG
AAGGAGTTGCTGAAGCGGACTCCACGGAAACACAGTGACTATGCAGCAGTGATGGAAGCC
CTCCAAGCCATGAAAGCTGTCTGTTCCAACATAAACGAGGCCAAGAGACAGATGGAGAAG
TTAGAAGTTTTAGAGGAATGGCAGTCTCACATTGAAGGCTGGGAGGGGTCCAACATCACT
GACACCTGCACTGAAATGCTAATGTGTGGAGTCTTACTGAAAATTTCTTCTGGAAATATT
CAAGAACGGGTGTTTTTTCTTTTCGATAATCTTTTGGTGTACTGCAAAAGAAAACACAGA
CGGTTGAAGAACAGCAAGGCATCTACAGATGGACATCGGTACCTTTTTCGTGGCCGGATC
AACACGGAGGTGATGGAAGTGGAGAATGTGGATGATGGCACCGCTGATTTCCATAGCAGT
GGACACATTGTTGTTAATGGATGGAAGATACATAACACAGCAAAAAATAAATGGTTTGTT
TGTATGGCAAAAACACCTGAAGAGAAGCATGAATGGTTTGAAGCTATTTTGAAAGAAAGA
GAACGGCGGAAAGGTTTAAAATTAGGAATGGAGCAAGATACCTGGGTCATGATCTCTGAA
CAGGGTGAGAAACTTTATAAAATGATGTGCAGACAAGGAAATCTGATCAAAGACCGAAAG
AGAAAACTGACTACGTTCCCTAAATGCTTTCTTGGAAGCGAATTTGTGTCATGGCTGTTG
GAAATTGGAGAGATTCACAGGCCTGAGGAAGGCGTGCACTTGGGACAAGCATTATTAGAA
AATGGAATCATTCACCATGTTACTGATAAACATCAATTCAAACCAGAACAGATGTTATAT
AGATTTCGCTATGATGATGGAACATTTTATCCAAGAAATGAGATGCAGGACGTGATTTCA
AAGGGTGTAAGATTATATTGTCGTCTTCATAGCCTTTTTACTCCAGTGATAAGAGATAAA
GATTACCATTTAAGGACCTACAAATCTGTGGTCATGGCCAACAAACTGATAGACTGGTTA
ATTGCACAGGGAGATTGCCGCACCAGAGAAGAGGCAATGATATTTGGCGTTGGACTCTGT
GACAATGGATTTATGCACCATGTCCTTGAAAAAAGCGAATTCAAAGATGAACCCCTACTT
TTCCGTTTTTTTTCGGATGAGGAAATGGAGGGATCAAATATGAAACATCGACTTATGAAA
CATGACTTAAAAGTTGTGGAAAATGTTATAGCTAAGTCATTATTGATTAAATCCAATGAA
GGCAGCTATGGCTTTGGATTAGAAGACAAAAATAAAGTTCCAATAATAAAGTTGGTAGAA
AAGGGATCTAATGCTGAGATGGCTGGCATGGAAGTCGGGAAAAAGATTTTTGCTATTAAT
GGTGACCTAGTTTTTATGAGACCTTTCAATGAAGTGGATTGCTTCCTGAAATCGTGTTTA
AACAGCAGAAAACCTCTAAGAGTTCTTGTGAGCACAAAGCCAAGAGAGACAGTGAAAATT
CCAGATTCAGCTGATGGACTTGGCTTCCAGATCCGGGGATTTGGCCCTTCTGTTGTGCAT
GCTGTAGGAAGAGGAACTGTGGCTGCAGCAGCTGGTCTTCACCCTGGACAGTGCATTATC
AAGGTGAATGGAATCAATGTCAGCAAAGAGACACATGCCAGTGTCATTGCACACGTTACA
GCCTGCAGGAAGTACAGGCGGCCAACGAAGCAAGATTCCATACAATGGGTTTATAATAGC
ATTGAGAGTGCTCAAGAAGACCTTCAAAAATCTCACTCCAAGCCCCCTGGAGATGAAGCA
GGGGATGCTTTTGACTGTAAAGTAGAAGAGGTTATTGACAAATTCAACACTATGGCCATC
ATTGATGGGAAGAAGGAGCATGTGAGTCTGACAGTGGACAATGTCCACCTGGAATATGGT
GTCGTGTATGAGTACGACAGCACAGCTGGCATCAAGTGCAATGTGGTGGAAAAGATGATT
GAGCCCAAAGGTTTCTTCAGCTTAACTGCCAAGATTCTTGAAGCCCTGGCTAAAAGTGAT
GAGCATTTTGTACAAAACTGTACCAGCCTAAATTCTCTAAATGAAGTGATTCCTACTGAC
CTTCAGAGTAAATTCAGTGCCCTTTGCAGTGAAAGAATTGAACACCTATGTCAGAGAATA
TCCAGTTATAAAAAGTTTTCTCGTGTACTGAAGAATAGGGCCTGGCCTACTTTTAAACAG
GCCAAATCTAAAATCTCCCCACTGCACAGCAGTGATTTCTGCCCTACCAACTGCCATGTC
AATGTGATGGAAGTTTCTTATCCCAAAACATCAACCTCTTTGGGAAGTGCATTTGGTGTT
CAGTTGGATAGCAGGAAGCATAATTCTCATGATAAAGAAAACAAATCTTCGGAGCAAGGG
AAACTGAGCCCTATGGTGTACATTCAGCACACCATCACAACCATGGCGGCCCCTTCAGGT
CTGTCTCTGGGACAGCAGGATGGCCATGGTCTCAGGTATCTGCTAAAAGAAGAAGACTTA
GAAACCCAAGACATCTATCAGAAACTGCTGGGCAAACTTCAGACTGCACTGAAAGAGGTG
GAGATGTGTGTTTGTCAAATAGATGACCTTCTGTCTTCAATAACATATTCTCCTAAATTA
GAACGTAAGACATCAGAGGGCATAATACCAACAGACAGTGACAATGAGAAGGGAGAAAGA
AACAGCAAACGGGTATGTTTTAATGTAGCAGGAGATGAACAGGAAGATTCTGGTCATGAC
ACCATCAGCAACAGAGACTCTTACAGTGACTGCAACAGCAATAGGAATTCCATCGCCTCC
TTCACCAGCATCTGCAGCAGCCAGTGCAGCTCGTATTTCCACAGTGATGAAATGGACTCA
GGTGATGAACTTCCCTTAAGTGTTCGCATATCTCATGATAAACAGGACAAGATACATAGT
TGCCTTGAGCATCTTTTCAGCCAGGTGGATTCAATTACCAATCTCCTAAAAGGGCAGGCT
GTTGTGAGGGCCTTTGACCAAACCAAGTATCTCACTCCAGGCCGAGGATTGCAAGAATTT
CAACAGGAAATGGAACCAAAGCTGAGTTGTCCAAAAAGGCTACGGCTTCATATCAAGCAA
GATCCTTGGAATCTTCCCAGCAGCGTCCGGACTCTTGCTCAGAACATCAGGAAATTTGTT
GAAGAGGTAAAGTGTAGGCTACTCCTGGCTCTTCTTGAATATTCAGATAGTGAGACACAG
CTCCGTAGAGACATGGTTTTCTGCCAGACTCTTGTGGCCACTGTCTGTGCCTTCTCTGAG
CAGCTCATGGCGGCCTTGAACCAGATGTTTGACAACAGCAAGGAAAATGAGATGGAAACT
TGGGAAGCCAGCAGGAGGTGGCTGGACCAGATAGCGAATGCAGGTGTTCTTTTTCACTTT
CAGTCACTTCTGTCACCAAACTTGACAGATGAACAAGCCATGTTAGAAGATACACTGGTT
GCACTATTTGATTTGGAAAAGGTTTCCTTTTACTTTAAACCATCAGAAGAGGAACCTCTG
GTTGCAAATGTTCCTCTTACATATCAAGCAGAAGGAAGTCGGCAAGCTCTGAAAGTTTAC
TTCTACATTGATAGTTATCATTTTGAACAACTTCCTCAACGGCTGAAAAATGGAGGAGGG
TTTAAAATTCATCCTGTTCTTTTTGCACAAGCACTAGAGAGCATGGAAGGATATTATTAC
AGAGACAATGTTTCTGTGGAAGAATTTCAAGCTCAGATAAATGCAGCCTCACTGGAAAAG
GTCAAACAGTACAACCAGAAGCTCAGGGCATTCTACTTGGACAAGTCAAATTCACCACCA
AACTCCACATCCAAAGCTGCCTATGTAGATAAGCTAATGAGGCCTCTCAACGCTTTGGAT
GAACTTTACCGACTGGTAGCCTCGTTTATCAGATCCAAGCGCACAGCTGCCTGTGCAAAC
ACAGCTTGCAGTGCTTCTGGGGTTGGACTGCTGTCAGTTTCCTCGGAGCTGTGCAACAGG
CTGGGCGCCTGCCACATCATCATGTGCAGCAGCGGTGTGCATCGGTGCACCCTGAGCGTG
ACGCTGGAGCAAGCCATCATTCTGGCCAGAAGCCACGGACTGCCACCTCGTTACATCATG
CAGGCTACAGATGTGATGCGGAAGCAGGGAGCAAGAGTTCAGAACACAGCGAAGAATTTG
GGAGTCAGAGACCGGACTCCACAGTCTGCACCAAGGCTGTACAAGCTGTGCGAGCCACCT
CCCCCAGCTGGAGAAGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 1606 |
| Molecular Weight
| 182620.5 |
| Theoretical pI
| 7.46 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK
VDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD
EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL
KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIT
DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI
NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER
ERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLL
EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS
KGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLC
DNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE
GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL
NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII
KVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEA
GDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI
EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRI
SSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGV
QLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDL
ETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTSEGIIPTDSDNEKGER
NSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDS
GDELPLSVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEF
QQEMEPKLSCPKRLRLHIKQDPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQ
LRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHF
QSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVY
FYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEK
VKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACAN
TACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIM
QATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE
|
| External Links |
|---|
| GenBank ID Protein
| 47578115 |
| UniProtKB/Swiss-Prot ID
| Q70Z35 |
| UniProtKB/Swiss-Prot Entry Name
| PREX2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_024870.2 |
| GeneCard ID
| PREX2 |
| GenAtlas ID
| PREX2 |
| HGNC ID
| HGNC:22950 |
| References |
|---|
| General References
| Not Available |