| Identification |
|---|
| HMDB Protein ID
| CDBP03555 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytohesin-4 |
| Description
| Not Available |
| Synonyms
|
- PH, SEC7 and coiled-coil domain-containing protein 4
|
| Gene Name
| CYTH4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ARF guanyl-nucleotide exchange factor activity |
| Specific Function
| Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| enzyme regulator activity |
| arf guanyl-nucleotide exchange factor activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of ras protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of arf protein signal transduction |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q12.3-q13.1 |
| SNPs
| CYTH4 |
| Gene Sequence
|
>1185 bp
ATGGACCTGTGCCACCCAGAGCCCGCGGAGCTGAGCAGCGGGGAGACGGAAGAGTTACAG
AGGATCAAGTGGCACCGAAAGCAGCTCCTGGAGGACATCCAGAAGCTGAAGGATGAGATT
GCAGATGTGTTTGCCCAAATCGACTGCTTCGAGAGTGCGGAGGAGAGCCGGATGGCCCAG
AAGGAGAAGGAGCTGTGTATTGGGCGCAAGAAGTTCAACATGGACCCCGCCAAGGGTATC
CAGTATTTCATTGAGCACAAGCTGCTGACCCCTGACGTCCAGGACATTGCACGGTTCCTG
TATAAAGGCGAGGGCCTCAACAAGACAGCCATTGGTACCTACCTGGGGGAGAGGGATCCC
ATCAACCTGCAGGTCCTCCAGGCCTTCGTGGACTGCCACGAGTTCGCCAACCTCAACCTC
GTCCAGGCCCTCAGGCAGTTCCTGTGGAGCTTCCGGCTGCCGGGCGAGGCCCAGAAGATA
GACCGGATGATGGAGGCCTTTGCCACTCGATACTGCCTCTGCAACCCAGGCGTCTTCCAG
TCCACAGACACCTGCTACGTGTTGTCCTTCTCCATCATCATGCTCAACACCAGCCTCCAC
AATCCCAACGTCCGGGACAGGCCGCCTTTCGAGCGCTTTGTGTCCATGAACCGCGGCATC
AACAATGGTAGCGACCTGCCCGAGGACCAGCTGCGGAACCTCTTCGACAGCATCAAGAGT
GAGCCATTCTCCATCCCTGAGGACGACGGCAATGACCTCACTCACACCTTCTTCAATCCA
GACCGGGAGGGTTGGCTGCTCAAGCTAGGGGGCCGCGTGAAGACGTGGAAACGGCGCTGG
TTCATCCTGACCGACAACTGCCTCTACTACTTCGAGTTCACCACTGACAAGGAGCCACGG
GGAATTATACCTCTTGAGAACCTCTCGGTGCAGAAGGTGGATGACCCCAAGAAGCCATTC
TGCCTGGAGCTCTACAACCCTAGCTGCCGAGGCCAGAAAATCAAGGCCTGCAAGACCGAT
GGCGACGGCAGGGTGGTGGAGGGCAAGCACGAATCGTACCGCATCTCAGCCACCAGTGCC
GAGGAACGTGACCAGTGGATCGAGTCCATCCGAGCCAGCATCACCCGTGTCCCCTTCTAC
GACCTGGTCTCTACTCGGAAGAAGAAGATTGCCAGCAAGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 394 |
| Molecular Weight
| 45671.6 |
| Theoretical pI
| 6.41 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cytohesin-4
MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ
KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP
INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ
STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS
EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR
GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA
EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
|
| External Links |
|---|
| GenBank ID Protein
| 6531383 |
| UniProtKB/Swiss-Prot ID
| Q9UIA0 |
| UniProtKB/Swiss-Prot Entry Name
| CYH4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF075458 |
| GeneCard ID
| CYTH4 |
| GenAtlas ID
| CYTH4 |
| HGNC ID
| HGNC:9505 |
| References |
|---|
| General References
| Not Available |