| Identification |
|---|
| HMDB Protein ID
| CDBP03532 |
| Secondary Accession Numbers
| Not Available |
| Name
| Brefeldin A-inhibited guanine nucleotide-exchange protein 2 |
| Description
| Not Available |
| Synonyms
|
- Brefeldin A-inhibited GEP 2
|
| Gene Name
| ARFGEF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| binding |
| enzyme regulator activity |
| arf guanyl-nucleotide exchange factor activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
| regulation of ras protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of arf protein signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q13.13 |
| SNPs
| ARFGEF2 |
| Gene Sequence
|
>5358 bp
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCC
GACAAGGAGGTGAAGCGGCCCCAGCACTCCCAGCTGCGCAGGGCCTGCCAGGTGGCGCTC
GATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCC
CCAAGGGTAGTCAGCACATCCCTTGACTGCTTGCAGAAACTCATCGCATACGGGCACATC
ACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATT
AAGGCTCTTCTGACTGCAGTGACTTCCCCACACATTGAAATTCATGAGGGTACTATCCTG
CAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAA
GTGTTGCAGGAGGCCAGAAGACTGGAAAAACCAATCCAGTCAAAACCCCAGTCCCCTGTG
ATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCT
GGAAAAGTAAGCACAGAAAATGGAGACGCACCCAGAGAAAGAGGCTCATCACTGTCAGGG
ACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGAAGCAGCGGAAAAGCATGGTCTGACAGAACCTGAGAGAGTTCTAGGTGAACTG
GAGTGCCAGGAATGTGCTATTCCCCCAGGAGTTGATGAAAACTCACAGACCAACGGGATA
GCCGATGACAGGCAGTCCTTGTCGTCAGCAGATAATCTGGAATCGGATGCACAAGGACAT
CAAGTGGCTGCCAGGTTCTCCCACGTTCTGCAGAAGGATGCCTTCCTTGTGTTCCGCTCC
CTGTGCAAGCTGTCCATGAAACCCCTTGGTGAAGGCCCTCCAGACCCAAAATCCCATGAG
CTGCGTTCCAAGGTGGTTTCCCTGCAGCTGCTCCTCTCTGTGTTGCAAAATGCTGGCCCC
GTATTCAGGACTCACGAGATGTTCATCAATGCAATCAAGCAATATCTCTGTGTGGCCTTG
TCCAAAAACGGCGTCTCTTCAGTGCCTGATGTCTTTGAGCTCTCTCTTGCCATTTTTCTT
ACTCTTCTTTCAAACTTTAAAATGCACTTGAAAATGCAGATAGAGGTCTTTTTCAAAGAG
ATTTTCCTGAACATTTTAGAAACATCAACAAGTTCTTTTGAGCACAGGTGGATGGTCATT
CAGACTCTGACGAGGATCTGTGCAGATGCCCAGTGTGTTGTGGATATTTATGTCAACTAC
GACTGTGATTTAAATGCTGCTAACATTTTTGAGCGCCTTGTAAATGATTTATCCAAAATT
GCTCAGGGAAGAAGTGGACATGAGCTGGGAATGACACCTCTGCAGGAGCTCAGCCTGAGG
AAGAAAGGCCTGGAGTGCCTCGTGTCCATTCTCAAGTGCATGGTGGAGTGGAGCAAAGAC
CTGTATGTGAATCCCAACCACCAGACCAGCCTCGGTCAGGAGAGGCTCACGGATCAGGAA
ATAGGGGATGGGAAAGGCCTTGACATGGCAAGACGGTGTAGTGTGACGTCCATGGAGTCC
ACAGTGTCCTCGGGGACCCAGACAACTGTTCAGGATGACCCTGAGCAATTTGAGGTCATC
AAGCAACAAAAAGAAATCATTGAACACGGCATCGAGCTGTTCAACAAGAAACCCAAGAGG
GGGATCCAGTTTCTCCAGGAGCAGGGCATGCTGGGAACGTCAGTTGAAGACATAGCCCAA
TTCCTGCACCAGGAGGAGCGCCTGGATTCCACCCAAGTAGGCGATTTTCTGGGAGATAGC
GCAAGGTTCAACAAGGAGGTGATGTATGCCTACGTGGACCAACTTGACTTCTGTGAAAAA
GAATTTGTCTCAGCCCTGCGGACATTCCTAGAAGGTTTCCGCCTACCTGGAGAAGCCCAA
AAGATTGACCGATTAATGGAGAAGTTTGCCGCAAGATACATAGAATGCAACCAAGGGCAA
ACTCTGTTTGCTAGTGCTGACACTGCTTATGTCCTAGCGTATTCAATTATTATGCTGACT
ACAGACTTGCACAGTCCTCAGGTAAAAAATAAAATGACGAAAGAGCAGTATATTAAAATG
AATCGGGGTATCAATGATAGTAAAGATCTGCCAGAAGAGTATCTCTCAAGCATCTATGAA
GAGATAGAAGGCAAGAAAATTGCAATGAAAGAAACAAAAGAGCTAACGATTGCAACCAAA
TCTACTAAGCAGAATGTAGCTAGTGAAAAGCAGCGGCGGCTGCTGTACAACTTAGAGATG
GAGCAAATGGCTAAAACAGCCAAAGCTCTGATGGAGGCTGTGAGCCATGCCAAAGCCCCG
TTTACCAGTGCCACTCACCTGGACCATGTCCGGCCAATGTTCAAACTGGTGTGGACGCCA
CTATTGGCAGCCTACAGCATCGGACTCCAGAACTGTGATGACACTGAAGTGGCCTCCTTG
TGTTTGGAAGGCATCCGATGTGCAATCCGAATCGCCTGCATCTTTGGAATGCAGCTGGAA
CGAGATGCCTATGTTCAGGCTCTTGCTCGCTTCTCCCTACTCACAGCCAGCTCCAGCATC
ACAAAAATGAAGCAGAAAAACATCGACACCATTAAGACGCTTATCACAGTGGCTCACACC
GATGGCAACTACCTTGGGAATTCCTGGCATGAGATCTTGAAATGCATCAGCCAGCTGGAG
CTCGCTCAGCTGATAGGAACCGGTGTGAAGACGCGCTACCTGTCTGGATCTGGGCGTGAA
AGAGAAGGGAGCCTGAAGGGCCACACATTGGCAGGAGAAGAGTTCATGGGCCTTGGCCTC
GGTAATTTGGTGAGTGGCGGAGTGAATAAAAGACAGATGGCCAGCTTCCAAGAATCGGTT
GGTGAGACCAGCTCGCAGAGTGTGGTTGTAGCTGTGGACAGGATTTTTACTGGGTCTACC
AGACTGGATGGAAATGCAATAGTTGACTTTGTCCGCTGGCTGTGTGCTGTGTCCATGGAT
GAACTGGCTTCCCCCCACCATCCTCGCATGTTCAGCTTGCAGAAGATTGTGGAGATATCA
TACTACAACATGAATCGGATCCGACTACAGTGGTCTCGAATATGGCATGTGATTGGAGAT
CACTTCAATAAGGTTGGCTGCAACCCTAATGAAGATGTGGCTATCTTTGCTGTTGACTCA
TTAAGGCAACTCTCCATGAAGTTTCTTGAGAAGGGTGAATTAGCCAACTTCCGTTTCCAG
AAAGATTTTCTGAGGCCCTTTGAGCATATTATGAAGAAAAACAGGTCTCCCACCATCCGG
GACATGGCGATCCGCTGCATTGCCCAGATGGTGAACTCCCAGGCGGCCAACATCCGCTCA
GGCTGGAAGAACATCTTTGCCGTGTTCCACCAGGCAGCCTCTGATCATGATGGGAACATT
GTGGAGCTGGCCTTCCAGACCACTTGCCACATTGTCACAACTATTTTCCAGCACCATTTT
CCTGCAGCCATCGATTCCTTTCAGGATGCTGTGAAGTGCTTATCAGAGTTCGCCTGCAAC
GCCGCTTTCCCTGACACGAGCATGGAAGCGATTCGGCTCATCCGCTTCTGTGGCAAATAC
GTCTCTGAGAGGCCTCGGGTGCTACAAGAATACACAAGTGATGACATGAATGTAGCTCCT
GGTGACAGAGTCTGGGTCCGAGGCTGGTTCCCCATCTTATTCGAACTCTCCTGCATCATT
AATAGATGCAAGTTAGATGTACGAACAAGGGGACTCACAGTCATGTTTGAGATCATGAAG
AGCTATGGCCACACCTTTGAAAAGCACTGGTGGCAGGACCTGTTCAGAATCGTGTTTCGG
ATTTTTGACAATATGAAACTCCCTGAGCAACTGTCAGAGAAATCTGAGTGGATGACAACA
ACCTGCAATCACGCACTTTATGCTATTTGTGATGTTTTTACCCAGTTTTATGAAGCTTTG
AATGAAGTTCTTCTTTCTGATGTATTTGCACAATTGCAGTGGTGTGTCAAACAAGATAAT
GAACAGTTGGCGCGATCAGGTACAAATTGCTTAGAAAACTTAGTAATATCCAATGGAGAG
AAATTCAGTCCTGAAGTCTGGGATGAAACCTGCAACTGTATGTTGGATATTTTCAAAACA
ACCATCCCACATGTTTTGCTGACATGGAGACCTGTAGGAATGGAGGAAGATTCATCAGAA
AAGCATTTGGATGTGGATCTGGACCGCCAGTCTTTAAGCAGCATAGATAAAAATCCCTCT
GAGAGGGGACAGAGCCAGCTCTCTAACCCAACAGATGACAGCTGGAAGGGTAGACCATAC
GCAAATCAGAAACTGTTTGCCAGCCTCCTCATCAAGTGTGTGGTCCAGTTGGAATTGATA
CAGACCATTGACAACATTGTGTTCTACCCTGCGACGAGCAAAAAGGAGGATGCAGAGCAC
ATGGTTGCCGCCCAGCAAGACACGCTGGATGCAGATATCCACATAGAGACGGAGGATCAG
GGCATGTATAAGTACATGTCTTCCCAGCACCTCTTCAAGCTGTTGGACTGTTTGCAGGAA
TCCCATTCATTCTCAAAGGCCTTCAACTCCAATTACGAGCAGCGGACTGTCCTGTGGCGA
GCAGGTTTTAAGGGCAAGTCTAAACCCAATCTTCTAAAACAAGAAACCAGCAGCCTGGCC
TGTTGTTTGAGGATCCTGTTTCGAATGTATGTTGATGAGAACCGCAGGGATTCCTGGGAA
GAAATACAGCAGAGACTTTTAACTGTTTGCAGTGAAGCTCTTGCCTATTTCATCACTGTG
AATTCTGAGAGCCATCGGGAGGCCTGGACAAGTCTCTTGTTGTTACTTCTAACTAAAACC
CTCAAAATAAATGATGAAAAGTTCAAAGCACATGCTTCAATGTACTACCCCTACTTGTGT
GAAATTATGCAGTTTGACCTGATCCCTGAGCTCCGAGCAGTTCTGCGGAAGTTCTTCCTA
CGGATAAGTGTTGTGTATAAGATATGGATACCAGAAGAGCCATCACAGGTACCAGCAGCA
CTGTCACCAGTGTGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1785 |
| Molecular Weight
| 202036.5 |
| Theoretical pI
| 6.28 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Brefeldin A-inhibited guanine nucleotide-exchange protein 2
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA
NFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVE
TICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQS
KPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSA
IKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGP
VFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKE
IFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQE
IGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKR
GIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLT
TDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATK
STKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSI
TEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGRE
REGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGD
HFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIR
DMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAP
GDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFR
IFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE
KHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELI
QTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQE
SHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWE
EIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLC
EIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW
|
| External Links |
|---|
| GenBank ID Protein
| 5052123 |
| UniProtKB/Swiss-Prot ID
| Q9Y6D5 |
| UniProtKB/Swiss-Prot Entry Name
| BIG2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF084521 |
| GeneCard ID
| ARFGEF2 |
| GenAtlas ID
| ARFGEF2 |
| HGNC ID
| HGNC:15853 |
| References |
|---|
| General References
| Not Available |