| Identification |
|---|
| HMDB Protein ID
| CDBP03509 |
| Secondary Accession Numbers
| Not Available |
| Name
| Iodotyrosine dehalogenase 1 |
| Description
| Not Available |
| Synonyms
|
- IYD-1
|
| Gene Name
| IYD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
|
| GO Classification
|
| Biological Process |
| cellular nitrogen compound metabolic process |
| thyroid hormone generation |
| Cellular Component |
| plasma membrane |
| integral to membrane |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| oxidoreductase activity |
|
| Cellular Location
|
- Cell membrane
- Single-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q25.1 |
| SNPs
| IYD |
| Gene Sequence
|
>870 bp
ATGTATTTCCTGACTCCCATCTTGGTAGCCATTCTCTGCATTTTGGTTGTGTGGATCTTT
AAAAATGCCGACAGAAGCATGGAGAAAAAGAAGGGGGAGCCTAGAACCAGGGCCGAAGCT
CGCCCCTGGGTGGATGAAGACTTAAAAGACAGCAGTGACCTGCACCAAGCAGAAGAAGAT
GCTGATGAATGGCAAGAATCAGAAGAAAATGTTGAACACATCCCCTTCTCTCATAACCAC
TATCCTGAGAAGGAAATGGTTAAGAGGTCTCAGGAATTTTATGAACTTCTCAATAAGAGA
CGGTCAGTCAGGTTCATAAGTAATGAGCAAGTCCCAATGGAAGTCATTGATAATGTCATC
AGAACGGCAGGAACAGCCCCGAGTGGGGCTCACACAGAGCCCTGGACCTTCGTGGTTGTG
AAGGACCCAGACGTGAAGCACAAGATTCGAAAGATCATTGAGGAGGAAGAGGAGATCAAC
TACATGAAAAGGATGGGACATCGCTGGGTCACAGACCTCAAGAAACTGAGAACCAACTGG
ATTAAAGAGTACTTGGATACTGCCCCTATTTTGATTCTCATTTTCAAACAAGTACATGGT
TTCGCCGCAAATGGCAAGAAAAAAGTCCACTACTACAATGAGATCAGTGTTTCCATCGCT
TGTGGCATCCTGCTAGCTGCCCTGCAGAATGCAGGTCTGGTGACTGTCACTACCACTCCT
CTCAACTGTGGCCCTCGACTGAGGGTGCTCCTGGGCCGCCCCGCACATGAAAAGCTGCTG
ATGCTGCTCCCCGTGGGGTACCCCAGCAAGGAGGCCACGGTGCCTGACCTCAAGCGCAAA
CCTCTGGACCAGATCATGGTGACAGTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 289 |
| Molecular Weight
| 33781.22 |
| Theoretical pI
| 7.187 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Iodotyrosine dehalogenase 1
MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED
ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI
RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW
IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTP
LNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6PHW0 |
| UniProtKB/Swiss-Prot Entry Name
| IYD1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY259176 |
| GeneCard ID
| IYD |
| GenAtlas ID
| IYD |
| HGNC ID
| HGNC:21071 |
| References |
|---|
| General References
| Not Available |