| Identification |
|---|
| HMDB Protein ID
| CDBP03504 |
| Secondary Accession Numbers
| Not Available |
| Name
| All-trans-retinol 13,14-reductase |
| Description
| Not Available |
| Synonyms
|
- All-trans-13,14-dihydroretinol saturase
- RetSat
- PPAR-alpha-regulated and starvation-induced gene protein
|
| Gene Name
| RETSAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).
|
| GO Classification
|
| Biological Process |
| retinol metabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| nuclear outer membrane |
| Function |
| oxidoreductase activity |
| catalytic activity |
| electron carrier activity |
| Molecular Function |
| all-trans-retinol 13,14-reductase activity |
|
| Cellular Location
|
- Peripheral membrane protein
- Endoplasmic reticulum membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Retinol Metabolism |    |  | | Vitamin A Deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2p11.2 |
| SNPs
| RETSAT |
| Gene Sequence
|
>1833 bp
ATGTGGCTTCCGCTGGTGCTGCTCCTGGCTGTGCTGCTGCTGGCCGTCCTCTGCAAAGTT
TACTTGGGACTATTCTCTGGCAGCTCCCCGAATCCTTTCTCCGAAGATGTCAAACGGCCC
CCAGCGCCCCTGGTAACTGACAAGGAGGCCAGGAAGAAGGTTCTCAAACAAGCTTTTTCA
GCCAACCAAGTGCCGGAGAAGCTGGATGTGGTGGTAATTGGCAGTGGCTTTGGGGGCCTG
GCTGCAGCTGCAATTCTAGCTAAAGCTGGCAAGCGAGTCCTGGTGCTGGAACAACATACC
AAGGCAGGGGGCTGCTGTCATACCTTTGGAAAGAATGGCCTTGAATTTGACACAGGAATC
CATTACATTGGGCGTATGGAAGAGGGCAGCATTGGCCGTTTTATCTTGGACCAGATCACT
GAAGGGCAGCTGGACTGGGCTCCCCTGTCCTCTCCTTTTGACATCATGGTACTGGAAGGG
CCCAATGGCCGAAAGGAGTACCCCATGTACAGTGGAGAGAAAGCCTACATTCAGGGCCTC
AAGGAGAAGTTTCCACAGGAGGAAGCTATCATTGACAAGTATATAAAGCTGGTTAAGGTG
GTATCCAGTGGAGCCCCTCATGCCATCCTGTTGAAATTCCTCCCATTGCCCGTGGTTCAG
CTCCTCGACAGGTGTGGGCTGCTGACTCGTTTCTCTCCATTCCTTCAAGCATCCACCCAG
AGCCTGGCTGAGGTCCTGCAGCAGCTGGGGGCCTCCTCTGAGCTCCAGGCAGTACTCAGC
TACATCTTCCCCACTTACGGTGTCACCCCCAACCACAGTGCCTTTTCCATGCACGCCCTG
CTGGTCAACCACTACATGAAAGGAGGCTTTTATCCCCGAGGGGGTTCCAGTGAAATTGCC
TTCCACACCATCCCTGTGATTCAGCGGGCTGGGGGCGCTGTCCTCACAAAGGCCACTGTG
CAGAGTGTGTTGCTGGACTCAGCTGGGAAAGCCTGTGGTGTCAGTGTGAAGAAGGGGCAT
GAGCTGGTGAACATCTATTGCCCCATCGTGGTCTCCAACGCAGGACTGTTCAACACCTAT
GAACACCTACTGCCGGGGAACGCCCGCTGCCTGCCAGGTGTGAAGCAGCAACTGGGGACG
GTGCGGCCCGGCTTAGGCATGACCTCTGTTTTCATCTGCCTGCGAGGCACCAAGGAAGAC
CTGCATCTGCCGTCCACCAACTACTATGTTTACTATGACACGGACATGGACCAGGCGATG
GAGCGCTACGTCTCCATGCCCAGGGAAGAGGCTGCGGAACACATCCCTCTTCTCTTCTTC
GCTTTCCCATCAGCCAAAGATCCGACCTGGGAGGACCGATTCCCAGGCCGGTCCACCATG
ATCATGCTCATACCCACTGCCTACGAGTGGTTTGAGGAGTGGCAGGCGGAGCTGAAGGGA
AAGCGGGGCAGTGACTATGAGACCTTCAAAAACTCCTTTGTGGAAGCCTCTATGTCAGTG
GTCCTGAAACTGTTCCCACAGCTGGAGGGGAAGGTGGAGAGTGTGACTGCAGGATCCCCA
CTCACCAACCAGTTCTATCTGGCTGCTCCCCGAGGTGCCTGCTACGGGGCTGACCATGAC
CTGGGCCGCCTGCACCCTTGTGTGATGGCCTCCTTGAGGGCCCAGAGCCCCATCCCCAAC
CTCTATCTGACAGGCCAGGATATCTTCACCTGTGGACTGGTCGGGGCCCTGCAAGGTGCC
CTGCTGTGCAGCAGCGCCATCCTGAAGCGGAACTTGTACTCAGACCTTAAGAATCTTGAT
TCTAGGATCCGGGCACAGAAGAAAAAGAATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 610 |
| Molecular Weight
| 66818.935 |
| Theoretical pI
| 8.274 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>All-trans-retinol 13,14-reductase
MWLPLVLLLAVLLLAVLCKVYLGLFSGSSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFS
ANQVPEKLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDTGI
HYIGRMEEGSIGRFILDQITEGQLDWAPLSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGL
KEKFPQEEAIIDKYIKLVKVVSSGAPHAILLKFLPLPVVQLLDRCGLLTRFSPFLQASTQ
SLAEVLQQLGASSELQAVLSYIFPTYGVTPNHSAFSMHALLVNHYMKGGFYPRGGSSEIA
FHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKKGHELVNIYCPIVVSNAGLFNTY
EHLLPGNARCLPGVKQQLGTVRPGLGMTSVFICLRGTKEDLHLPSTNYYVYYDTDMDQAM
ERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYEWFEEWQAELKG
KRGSDYETFKNSFVEASMSVVLKLFPQLEGKVESVTAGSPLTNQFYLAAPRGACYGADHD
LGRLHPCVMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKNLD
SRIRAQKKKN
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6NUM9 |
| UniProtKB/Swiss-Prot Entry Name
| RETST_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY358568 |
| GeneCard ID
| RETSAT |
| GenAtlas ID
| RETSAT |
| HGNC ID
| HGNC:25991 |
| References |
|---|
| General References
| Not Available |