| Identification |
|---|
| HMDB Protein ID
| CDBP03490 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein-methionine sulfoxide oxidase MICAL3 |
| Description
| Not Available |
| Synonyms
|
- Molecule interacting with CasL protein 3
- MICAL-3
|
| Gene Name
| MICAL3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.
|
| GO Classification
|
| Biological Process |
| actin filament depolymerization |
| exocytosis |
| Cellular Component |
| cytoskeleton |
| cytoplasm |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| zinc ion binding |
| monooxygenase activity |
| oxidoreductase activity |
| Molecular Function |
| actin binding |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen |
| metal ion binding |
| FAD binding |
| zinc ion binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q11.21 |
| SNPs
| MICAL3 |
| Gene Sequence
|
>6009 bp
ATGGAGGAGAGGAAGCATGAGACCATGAACCCAGCTCATGTCCTCTTTGACCGGTTTGTC
CAGGCCACCACCTGCAAGGGAACCCTCAAGGCTTTCCAGGAGCTCTGTGACCACCTGGAA
CTAAAGCCAAAGGACTACCGCTCCTTCTATCACAAGCTCAAGTCCAAGCTTAACTACTGG
AAAGCCAAAGCCCTCTGGGCAAAATTGGACAAACGGGGCAGTCACAAAGACTACAAAAAG
GGAAAAGCGTGCACTAACACCAAGTGTCTCATCATTGGGGCTGGCCCCTGTGGTCTCCGT
ACAGCCATCGACTTATCCTTACTGGGGGCCAAGGTGGTTGTTATTGAGAAACGAGATGCC
TTCTCCCGCAACAACGTCTTGCATCTCTGGCCATTCACCATACATGATCTACGAGGTCTG
GGTGCCAAGAAGTTCTATGGCAAGTTCTGTGCTGGAGCCATCGACCATATCAGTATCCGT
CAGCTCCAACTAATACTTTTGAAAGTAGCCTTGATCCTAGGCATTGAAATCCACGTCAAT
GTGGAATTCCAAGGACTTATACAGCCTCCTGAGGACCAAGAGAATGAACGGATAGGCTGG
CGGGCACTGGTGCACCCCAAGACTCATCCTGTGTCAGAGTATGAATTTGAAGTGATCATC
GGTGGGGATGGTCGGAGGAACACCTTGGAAGGGTTTCGTCGGAAAGAATTCCGTGGCAAA
CTGGCCATCGCCATCACGGCAAATTTTATCAACCGAAATACAACAGCAGAAGCTAAAGTG
GAAGAGATCAGTGGTGTGGCTTTTATATTCAACCAAAAATTTTTCCAGGAACTGAGGGAA
GCCACAGGTATTGACTTGGAGAACATCGTTTACTACAAAGATGACACACACTATTTCGTT
ATGACAGCCAAAAAGCAGAGTTTGCTGGACAAAGGAGTGATACTACATGACTACGCCGAC
ACAGAGCTCCTGCTTTCCCGAGAAAACGTGGACCAGGAGGCTCTGCTCAGCTATGCCAGG
GAGGCGGCAGACTTCTCTACCCAGCAGCAGCTGCCGTCTCTGGATTTTGCCATCAATCAC
TATGGGCAGCCCGATGTGGCCATGTTTGACTTCACTTGTATGTATGCCTCCGAGAACGCC
GCCTTGGTGCGGGAGCAGAACGGACACCAGTTACTAGTGGCTCTGGTCGGGGACAGCCTC
CTAGAGCCTTTCTGGCCAATGGGAACAGGAATAGCCCGGGGCTTTCTAGCTGCTATGGAC
TCTGCCTGGATGGTCCGAAGTTGGTCTCTAGGAACGAGCCCTTTGGAAGTGCTGGCAGAG
AGGGAAAGTATTTACAGGTTGCTGCCTCAGACCACCCCTGAGAATGTGAGTAAGAACTTC
AGCCAGTACAGTATCGACCCTGTCACTCGGTATCCCAATATCAACGTCAACTTCCTCCGG
CCAAGCCAGGTGCGCCATTTATATGATACTGGCGAAACAAAAGATATTCACCTGGAAATG
GAGAGCCTGGTGAATTCCCGAACCACCCCCAAATTGACTCGCAATGAGTCTGTAGCTCGT
TCAAGCAAACTGCTGGGTTGGTGCCAGAGGCAGACAGATGGCTATGCAGGGGTAAACGTG
ACAGATCTCACCATGTCCTGGAAAAGTGGCTTGGCCCTTTGTGCAATTATCCATAGATAC
CGCCCTGACCTGATAGATTTTGATTCTTTGGATGAGCAAAATGTGGAGAAGAATAACCAA
CTGGCCTTTGACATTGCTGAGAAGGAATTGGGCATTTCTCCCATCATGACAGGCAAAGAA
ATGGCCTCCGTGGGGGAGCCTGATAAGCTGTCCATGGTGATGTACCTGACTCAGTTCTAC
GAGATGTTTAAGGACTCCCTCCCCTCTAGCGACACCTTGGACCTAAATGCCGAGGAGAAA
GCAGTCCTGATAGCCAGCACCAGATCCCCTATCTCCTTCCTAAGCAAACTTGGCCAGACC
ATCTCTCGGAAGCGTTCTCCCAAGGATAAAAAGGAAAAGGACTTGGATGGTGCTGGGAAG
AGGAGAAAGACCAGTCAATCAGAGGAGGAGGAAGCTCCTCGGGGCCACAGAGGAGAAAGA
CCGACCCTGGTGAGCACTCTGACAGACAGGAGGATGGACGTTGCCGTTGGGAACCAGAAC
AAAGTGAAGTACATGGCGACCCAGCTGCTGGCCAAATTTGAAGAGAATGCGCCCGCACAG
TCCATCGGCATACGGAGACAGGGCTCCATGAAGAAGGAGTTCCCGCAGAACCTGGGAGGC
AGCGACACATGCTACTTCTGCCAGAAGCGGGTCTACGTGATGGAGAGGCTGAGTGCCGAG
GGCAAGTTCTTCCACCGGAGCTGCTTCAAGTGCGAGTACTGCGCCACCACCCTGCGCCTC
TCGGCCTACGCCTACGACATCGAGGATGGTAAATTCTACTGTAAGCCACACTACTGCTAT
CGACTCTCTGGCTACGCACAAAGGAAGAGACCGGCAGTGGCTCCCCTGTCTGGAAAGGAG
GCCAAAGGACCCCTGCAGGATGGCGCCACCACAGATGCAAACGGACGGGCCAACGCCGTG
GCCAGCTCCACTGAGAGAACCCCAGGTTCAGGCGTGAACGGCCTGGAGGAGCCCAGCATC
GCCAAGCGACTGAGGGGCACCCCAGAGCGGATCGAGCTGGAGAACTACCGCCTGTCCCTG
AGGCAGGCTGAGGCACTGCAGGAGGTACCGGAGGAGACTCAGGCCGAGCACAACCTGAGC
AGCGTGCTGGACACGGGCGCCGAGGAGGACGTCGCCAGCAGTAGTTCCGAGTCTGAGATG
GAGGAGGAGGGAGAGGAGGAGGAGGAGGAGCCTCGCCTGCCCCCATCTGACCTGGGTGGT
GTTCCGTGGAAGGAGGCCGTGCGGATCCATGCCCTTCTGAAAGGGAAAAGTGAAGAGGAG
CTAGAGGCCTCAAAGAGCTTTGGGCCTGGGAATGAAGAGGAGGAGGAGGAGGAGGAAGAA
TATGAAGAGGAGGAGGAGGAGGACTATGACGAGGAGGAGGAAGAGTCCAGTGAAGCCGGG
AACCAGAGGCTCCAGCAGGTCATGCACGCGGCGGATCCTCTGGAGATCCAGGCTGACGTG
CACTGGACTCATATCCGTGAGAGAGAGGAGGAAGAGAGGATGGCGCCGGCCTCTGAGTCC
TCTGCTTCCGGAGCCCCATTGGATGAGAATGACCTAGAGGAAGATGTGGACTCAGAACCA
GCCGAGATAGAAGGGGAGGCAGCAGAGGATGGGGACCCAGGGGACACTGGTGCTGAGCTG
GATGATGATCAGCACTGGTCTGACAGCCCGTCGGATGCTGACAGAGAGCTGCGTTTGCCG
TGCCCAGCTGAGGGGGAAGCAGAGCTGGAGCTGAGGGTGTCGGAAGATGAGGAGAAGCTG
CCCGCCTCACCGAAGCACCAAGAGAGAGGTCCCTCCCAAGCCACCAGCCCCATCCGGTCT
CCCCAGGAATCAGCTCTTCTGTTCATTCCAGTCCACAGCCCCTCAACAGAGGGGCCCCAA
CTCCCACCTGTCCCTGCCGCCACCCAGGAGAAATCACCTGAGGAGCGCCTTTTCCCTGAG
CCTTTGCTCCCCAAAGAGAAGCCCAAAGCTGATGCCCCCTCGGATCTGAAAGCTGTGCAC
TCTCCCATCCGATCACAGCCAGTGACCCTGCCAGAAGCTAGGACTCCTGTCTCACCAGGG
AGCCCGCAGCCCCAGCCACCCGTGGCGGCCTCCACGCCCCCACCCAGCCCACTCCCCATC
TGCTCCCAGCCCCAGCCTTCCACCGAGGCCACTGTCCCATCCCCTACCCAGTCCCCCATA
CGCTTCCAGCCTGCCCCGGCCAAAACATCCACCCCACTGGCCCCTCTCCCTGTCCAAAGC
CAAAGTGACACCAAGGACAGACTGGGCAGCCCCCTTGCTGTGGATGAGGCCCTCAGACGG
AGCGACCTGGTGGAGGAGTTCTGGATGAAGAGTGCGGAGATCCGCCGCAGCCTCGGGCTC
ACACCTGTGGACCGCAGCAAGGGGCCCGAGCCCAGCTTCCCCACGCCTGCCTTCAGGCCA
GTGTCCCTCAAATCCTATTCCGTTGAAAAGTCCCCCCAGGATGAGGGACTCCACCTTCTC
AAGCCTCTGTCCATCCCCAAAAGGCTGGGCCTGCCAAAGCCGGAAGGCGAGCCGTTGTCC
CTGCCAACCCCCCGGTCCCCGTCCGACAGAGAGCTACGCAGCGCCCAGGAGGAGCGCAGG
GAGCTGTCCAGCAGCTCTGGCCTGGGCCTGCACGGGAGCTCCTCCAACATGAAGACACTG
GGCAGCCAGAGCTTCAACACCTCGGACTCCGCCATGCTCACGCCCCCCTCCAGCCCGCCC
CCACCGCCACCCCCGGGCGAGGAGCCCGCCACCTTGCGGAGGAAGCTCAGGGAGGCCGAG
CCCAATGCCTCGGTGGTCCCGCCGCCCTTGCCCGCCACCTGGATGCGGCCCCCCCGGGAG
CCTGCTCAGCCCCCCAGAGAGGAGGTGCGGAAGTCGTTTGTGGAGAGCGTGGAGGAGATT
CCCTTTGCTGATGATGTGGAGGACACCTATGACGACAAGACTGAGGACTCAAGCCTGCAG
GAGAAATTCTTCACGCCCCCGTCCTGCTGGCCGCGCCCCGAGAAGCCTCGCCACCCGCCC
CTGGCCAAGGAGAACGGGAGGCTGCCTGCTCTGGAGGGGACGCTGCAGCCACAGAAGAGG
GGGCTGCCCTTGGTGTCCGCGGAAGCCAAGGAGTTGGCCGAGGAGCGCATGCGAGCCAGG
GAGAAGTCCGTGAAGAGCCAGGCGCTGCGGGACGCCATGGCCAGGCAGCTGAGCAGGATG
CAGCAGATGGAGCTGGCCTCAGGCGCCCCCAGGCCCCGCAAGGCGTCCTCAGCACCCTCC
CAGGGCAAGGAGCGCCGGCCTGACTCCCCCACACGCCCCACTCTCAGGGGCTCCGAGGAG
CCCACCCTGAAGCATGAAGCCACCAGCGAGGAGGTCCTCTCCCCGCCGTCGGACTCAGGG
GGCCCAGATGGCTCTTTCACTTCATCCGAGGGCTCCAGTGGGAAGAGCAAGAAGAGGTCG
TCACTCTTCTCCCCCCGCAGAAACAAGAAGGAGAAGAAGTCCAAAGGCGAGGGCCGGCCC
CCGGAGAAGCCCAGCTCCAACCTCCTAGAAGAAGCCGCCGCCAAACCCAAGTCCCTGTGG
AAGTCCGTCTTCTCCGGGTACAAGAAGGACAAGAAGAAGAAGGCCGACGACAAGTCCTGC
CCCAGCACCCCCTCCAGCGGGGCCACGGTGGACTCTGGAAAGCACAGGGTGCTTCCCGTC
GTAAGGGCAGAGCTGCAGCTCCGGCGCCAGCTGAGCTTCTCCGAGGACTCAGACCTCTCC
AGCGACGATGTCCTTGAGAAGTCCTCACAGAAGTCCCGGCGAGAGCCAAGAACCTACACG
GAGGAGGAACTGAATGCCAAGCTGACCCGGCGTGTGCAAAAGGCAGCTCGGAGACAGGCC
AAGCAGGAGGAGCTTAAGCGGCTGCATCGAGCCCAGATCATCCAGCGGCAGCTGCAGCAG
GTGGAGGAGAGGCAGCGGCGGCTGGAGGAAAGGGGCGTGGCTGTGGAGAAGGCGCTCCGG
GGCGAAGCAGGCATGGGCAAGAAGGACGACCCCAAGCTGATGCAGGAGTGGTTCAAGCTA
GTGCAGGAGAAGAACGCCATGGTGCGCTACGAGTCGGAGCTGATGATCTTTGCCCGGGAG
CTGGAGCTGGAAGACCGGCAGAGTCGACTGCAGCAGGAGCTCCGGGAACGCATGGCAGTG
GAAGATCACCTTAAGACTGAGGAGGAGCTGTCAGAAGAGAAGCAGATTCTCAATGAGATG
CTGGAGGTGGTGGAGCAGAGAGACTCACTGGTGGCGCTGCTGGAGGAGCAGCGGCTCCGG
GAGAGAGAGGAGGACAAGGACCTGGAGGCTGCCATGCTGTCCAAGGGCTTCAGCCTTAAC
TGGTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 2002 |
| Molecular Weight
| 109046.185 |
| Theoretical pI
| 7.85 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein MICAL-3
MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW
KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA
FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN
VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK
LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV
MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH
YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD
SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR
PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV
TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE
MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT
ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN
KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE
GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE
AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL
RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG
VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG
NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEP
AEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL
PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE
PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPI
CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR
SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL
KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL
GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE
PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP
LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM
QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG
GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW
KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS
SDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQ
VEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARE
LELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLR
EREEDKDLEAAMLSKGFSLNWS
|
| External Links |
|---|
| GenBank ID Protein
| 209862789 |
| UniProtKB/Swiss-Prot ID
| Q7RTP6 |
| UniProtKB/Swiss-Prot Entry Name
| MICA3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_015241.2 |
| GeneCard ID
| MICAL3 |
| GenAtlas ID
| MICAL3 |
| HGNC ID
| HGNC:24694 |
| References |
|---|
| General References
| Not Available |