| Identification |
|---|
| HMDB Protein ID
| CDBP03489 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein-methionine sulfoxide oxidase MICAL2 |
| Description
| Not Available |
| Synonyms
|
- Molecule interacting with CasL protein 2
- MICAL-2
|
| Gene Name
| MICAL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity).
|
| GO Classification
|
| Biological Process |
| actin filament depolymerization |
| Cellular Component |
| cytoskeleton |
| cytoplasm |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| zinc ion binding |
| monooxygenase activity |
| oxidoreductase activity |
| Molecular Function |
| FAD binding |
| zinc ion binding |
| actin binding |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen |
| metal ion binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11p15.3 |
| SNPs
| MICAL2 |
| Gene Sequence
|
>3375 bp
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTC
CAGGCATCCACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGAC
CTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGA
GGGAAGTCGTGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGC
ACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGGGGCCTG
GGAGCCAAGAAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGC
CAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGG
CGGGCAGAATTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATT
GGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTG
GAAGAGATTAGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAA
GAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGAC
ACAGAGATGCTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGG
GAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCG
GCCCTGGTGCGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTG
CTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAA
AGGGAAAGTCTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTT
GAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGA
CTGGGCTCGGTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGC
AAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCT
GAGCTCATCAACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCA
TTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTC
TTCCGGGGCACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCT
GACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGG
AAGGGCTTCACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAAT
CAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT
CAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAACGC
CGTGTCTCAGGGATAGGTAAGCCGGTCCTGTGCTCTTCCTCCGGCCCTCCTGTTCACTCT
TGCTGCCCCAAGCCGGAGGAGGCCACACCCAGCCCATCACCTCCTCTGAAAAGGCAGTTC
CCCTCTGTGGTCGTGACGGGGCACGTGCTCAGAGAGCTCAAGCAAGTGTCTGCTGGCAGT
GAGTGCCTGAGCAGACCTTGGAGAGCCAGAGCCAAGTCTGACCTACAGCTGGGTGGGACA
GAAAATTTCGCTACCCTGCCTTCTACCCGCCCGAGGGCGCAGGCTCTTTCCGGGGTGCTG
TGGCGGCTGCAGCAAGTGGAGGAAAAGATTCTCCAGAAGAGGGCTCAGAACTTGGCCAAC
AGGGAATTTCACACAAAGAACATTAAGGAGAAGGCGGCTCACCTTGCCTCCATGTTTGGA
CACGGGGATTTCCCGCAGAATAAACTACTCTCTAAAGGCCTGTCTCATACTCATCCTCCA
TCTCCTCCCTCTCGCCTTCCGTCTCCTGATCCAGCTGCTTCTTCCTCTCCATCAACTGTT
GACTCTGCTTCTCCTGCCAGAAAGGAAAAGAAGTCACCTTCAGGGTTCCATTTTCATCCC
AGCCATTTGAGAACAGTGCATCCTCAGCTGACGGTAGGGAAAGTGTCCAGCGGAATAGGG
GCTGCAGCTGAAGTCCTGGTCAATCTGTACATGAATGATCACAGACCTAAGGCCCAGGCC
ACCTCTCCAGACCTGGAATCTATGCGAAAGTCATTTCCCCTTAACCTGGGAGGCAGCGAC
ACGTGTTACTTCTGTAAGAAACGTGTGTACGTGATGGAACGGCTGAGCGCCGAGGGCCAC
TTCTTCCACCGGGAGTGTTTCCGCTGCAGCATCTGTGCCACCACCTTGCGCCTGGCCGCC
TACACCTTTGACTGCGATGAAGGCAAATTTTACTGCAAGCCTCACTTCATTCACTGTAAA
ACCAATAGCAAACAACGGAAGAGACGGGCAGAGTTGAAGCAACAAAGAGAGGAGGAGGCA
ACATGGCAAGAGCAGGAAGCCCCTCGGAGAGACACTCCCACCGAAAGTTCTTGCGCAGTG
GCCGCCATTGGCACCCTGGAAGGCAGCCCCCCAGTTCATTTCAGCCTTCCAGTGCTACAC
CCACTTCTTGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1124 |
| Molecular Weight
| 126687.955 |
| Theoretical pI
| 8.641 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein MICAL-2
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTW
KAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDS
FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGK
LAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFV
MTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFD
TAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVR
PHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMA
SAQEPDKLSMVMYLSKFYELFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPR
KRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN
QLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQF
PSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVL
WRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKLLSKGLSHTHPP
SPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIG
AAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGH
FFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEA
TWQEQEAPRRDTPTESSCAVAAIGTLEGSPPVHFSLPVLHPLLG
|
| External Links |
|---|
| GenBank ID Protein
| 7662284 |
| UniProtKB/Swiss-Prot ID
| O94851 |
| UniProtKB/Swiss-Prot Entry Name
| MICA2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_014632.2 |
| GeneCard ID
| MICAL2 |
| GenAtlas ID
| MICAL2 |
| HGNC ID
| HGNC:24693 |
| References |
|---|
| General References
| Not Available |