| Identification |
|---|
| HMDB Protein ID
| CDBP03488 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein-methionine sulfoxide oxidase MICAL1 |
| Description
| Not Available |
| Synonyms
|
- Molecule interacting with CasL protein 1
- NEDD9-interacting protein with calponin homology and LIM domains
- MICAL-1
|
| Gene Name
| MICAL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.
|
| GO Classification
|
| Biological Process |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of protein phosphorylation |
| actin filament depolymerization |
| signal transduction |
| negative regulation of apoptotic process |
| Cellular Component |
| cytoplasm |
| intermediate filament |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| zinc ion binding |
| monooxygenase activity |
| oxidoreductase activity |
| Molecular Function |
| metal ion binding |
| FAD binding |
| zinc ion binding |
| actin binding |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q21 |
| SNPs
| MICAL1 |
| Gene Sequence
|
>3204 bp
ATGGCTTCACCTACCTCCACCAACCCAGCGCATGCCCACTTTGAGAGCTTCCTGCAGGCC
CAGCTGTGCCAGGACGTGCTGAGCAGCTTCCAGGAGCTGTGTGGGGCCCTGGGGCTGGAA
CCCGGTGGGGGGCTGCCCCAGTACCACAAGATCAAGGACCAGCTCAACTACTGGAGCGCC
AAGTCACTGTGGACCAAGCTGGACAAGCGAGCAGGCCAGCCTGTCTACCAGCAGGGCCGG
GCCTGCACCAGCACCAAGTGCCTGGTGGTGGGTGCTGGACCTTGCGGGCTGCGGGTCGCT
GTGGAGCTGGCGCTGCTGGGGGCCCGAGTGGTGCTGGTGGAAAAGCGCACCAAGTTCTCT
CGCCACAACGTGCTCCACCTCTGGCCCTTCACCATCCACGACCTGCGGGCACTCGGTGCT
AAGAAGTTCTACGGGCGCTTCTGCACCGGCACCCTGGACCACATCAGCATCAGGCAGCTC
CAGCTGCTTCTGCTGAAGGTAGCATTGCTGCTGGGGGTGGAAATTCACTGGGGTGTCACT
TTCACTGGCCTCCAGCCCCCTCCTAGGAAGGGGAGTGGCTGGCGTGCCCAGCTCCAACCC
AACCCCCCTGCCCAGCTGGCCAACTATGAATTTGACGTCCTTATCTCGGCTGCAGGAGGT
AAATTCGTCCCTGAAGGCTTCAAAGTTCGAGAAATGCGAGGCAAACTGGCCATTGGCATC
ACAGCCAACTTTGTGAATGGACGCACCGTGGAGGAGACACAGGTGCCGGAGATCAGTGGT
GTAGCCAGGATCTACAACCAGAGCTTCTTCCAGAGCCTTCTCAAAGCCACAGGCATTGAT
CTGGAGAACATTGTGTACTACAAGGACGACACCCACTACTTTGTGATGACAGCCAAGAAG
CAGTGCCTGCTGCGGCTGGGGGTGCTGCGCCAGGACTGGCCAGACACCAATCGGCTGCTG
GGCAGTGCCAATGTGGTGCCCGAGGCTCTGCAGCGCTTTACCCGGGCAGCTGCTGACTTT
GCCACCCATGGCAAGCTCGGGAAACTAGAGTTTGCCCAGGATGCCCATGGGCAGCCTGAT
GTCTCTGCCTTTGACTTCACGAGCATGATGCGGGCAGAGAGTTCTGCTCGTGTGCAAGAG
AAGCATGGCGCCCGCCTGCTGCTGGGACTGGTGGGGGACTGCCTGGTGGAGCCCTTCTGG
CCCCTGGGCACTGGAGTGGCACGGGGCTTCCTGGCAGCCTTTGATGCAGCCTGGATGGTG
AAGCGGTGGGCAGAGGGCGCTGAGTCCCTAGAGGTGTTGGCTGAGCGTGAGAGCCTGTAC
CAGCTTCTGTCACAGACATCCCCAGAAAACATGCATCGCAATGTGGCCCAGTATGGGCTG
GACCCAGCCACCCGCTACCCCAACCTGAACCTCCGGGCAGTGACCCCCAATCAGGTACGA
GACCTGTATGATGTGCTAGCCAAGGAGCCTGTGCAGAGGAACAACGACAAGACAGATACA
GGGATGCCAGCCACCGGGTCGGCAGGCACCCAGGAGGAGCTGCTACGCTGGTGCCAGGAG
CAGACAGCTGGGTACCCGGGAGTCCACGTCTCCGATTTGTCTTCCTCCTGGGCTGATGGG
CTAGCTCTGTGTGCCCTGGTGTACCGGCTGCAGCCTGGCCTGCTGGAACCCTCAGAGCTG
CAGGGGCTGGGAGCTCTGGAAGCAACTGCTTGGGCACTAAAGGTGGCAGAGAATGAGCTG
GGCATCACACCGGTGGTGTCTGCACAGGCCGTGGTAGCAGGGAGTGACCCACTGGGCCTC
ATTGCCTACCTCAGCCACTTCCACAGTGCCTTCAAGAGCATGGCCCACAGCCCAGGCCCT
GTCAGCCAGGCCTCCCCAGGGACCTCCAGTGCTGTATTATTCCTTAGTAAACTTCAGAGG
ACCCTGCAGCGATCCCGGGCCAAGGAAAATGCAGAGGATGCTGGTGGCAAGAAGCTGCGC
TTGGAGATGGAGGCCGAGACCCCAAGTACTGAGGTGCCACCTGACCCAGAGCCTGGTGTA
CCCCTGACACCCCCATCCCAACACCAGGAGGCCGGTGCTGGGGACCTGTGTGCACTTTGT
GGGGAACACCTCTATGTCCTGGAACGCCTCTGTGTCAACGGCCATTTCTTCCACCGGAGC
TGCTTCCGCTGCCATACCTGTGAGGCCACACTGTGGCCAGGTGGCTATGAGCAGCACCCA
GGAGATGGACATTTCTACTGCCTCCAGCACCTGCCCCAGACAGACCACAAAAAGGAAGGC
AGCGATAGAGGCCCTGAGAGTCCGGAGCTCCCCACACCAAGTGAGAATAGCATGCCACCA
GGCCTCTCAACTCCCACAGCCTCGCAGGAGGGGGCCGGTCCTGTTCCAGATCCCAGCCAG
CCCACCCGTCGGCAGATCCGCCTCTCCAGCCCGGAGCGCCAGCGGTTGTCCTCCCTTAAC
CTTACCCCTGACCCGGAAATGGAGCCTCCACCCAAGCCTCCCCGCAGCTGCTCCGCCTTG
GCCCGCCACGCCCTGGAGAGCAGCTTTGTGGGCTGGGGCCTGCCAGTCCAGAGCCCTCAA
GCTCTTGTGGCCATGGAGAAGGAGGAAAAAGAGAGTCCCTTCTCCAGTGAAGAGGAAGAA
GAAGATGTGCCTTTGGACTCAGATGTGGAACAGGCCCTGCAGACCTTTGCCAAGACCTCA
GGCACCATGAATAACTACCCAACATGGCGTCGGACTCTGCTGCGCCGTGCGAAGGAGGAG
GAGATGAAGAGGTTCTGCAAGGCCCAGACCATCCAACGGCGACTAAATGAGATTGAGGCT
GCCTTGAGGGAGCTAGAGGCCGAGGGCGTGAAGCTGGAGCTGGCCTTGAGGCGCCAGAGC
AGTTCCCCAGAACAGCAAAAGAAACTATGGGTAGGACAGCTGCTACAGCTCGTTGACAAG
AAAAACAGCTTGGTGGCTGAGGAGGCCGAGCTCATGATCACGGTGCAGGAATTGAATCTG
GAGGAGAAACAGTGGCAGCTGGACCAGGAGCTACGAGGCTACATGAACCGGGAAGAAAAC
CTAAAGACAGCTGCTGATCGGCAGGCTGAGGACCAGGTCCTGAGGAAGCTGGTGGATTTG
GTCAACCAGAGAGATGCCCTCATCCGCTTCCAGGAGGAGCGCAGGCTCAGCGAGCTGGCC
TTGGGGACAGGGGCCCAGGGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1067 |
| Molecular Weight
| 108551.41 |
| Theoretical pI
| 6.481 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NEDD9-interacting protein with calponin homology and LIM domains
MASPTSTNPAHAHFESFLQAQLCQDVLSSFQELCGALGLEPGGGLPQYHKIKDQLNYWSA
KSLWTKLDKRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAVELALLGARVVLVEKRTKFS
RHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVT
FTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAAGGKFVPEGFKVREMRGKLAIGI
TANFVNGRTVEETQVPEISGVARIYNQSFFQSLLKATGIDLENIVYYKDDTHYFVMTAKK
QCLLRLGVLRQDWPDTNRLLGSANVVPEALQRFTRAAADFATHGKLGKLEFAQDAHGQPD
VSAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMV
KRWAEGAESLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVR
DLYDVLAKEPVQRNNDKTDTGMPATGSAGTQEELLRWCQEQTAGYPGVHVSDLSSSWADG
LALCALVYRLQPGLLEPSELQGLGALEATAWALKVAENELGITPVVSAQAVVAGSDPLGL
IAYLSHFHSAFKSMAHSPGPVSQASPGTSSAVLFLSKLQRTLQRSRAKENAEDAGGKKLR
LEMEAETPSTEVPPDPEPGVPLTPPSQHQEAGAGDLCALCGEHLYVLERLCVNGHFFHRS
CFRCHTCEATLWPGGYEQHPGDGHFYCLQHLPQTDHKAEGSDRGPESPELPTPSENSMPP
GLSTPTASQEGAGPVPDPSQPTRRQIRLSSPERQRLSSLNLTPDPEMEPPPKPPRSCSAL
ARHALESSFVGWGLPVQSPQALVAMEKEEKESPFSSEEEEEDVPLDSDVEQALQTFAKTS
GTMNNYPTWRRTLLRRAKEEEMKRFCKAQTIQRRLNEIEAALRELEAEGVKLELALRRQS
SSPEQQKKLWVGQLLQLVDKKNSLVAEEAELMITVQELNLEEKQWQLDQELRGYMNREEN
LKTAADRQAEDQVLRKLVDLVNQRDALIRFQEERRLSELALGTGAQG
|
| External Links |
|---|
| GenBank ID Protein
| 19570335 |
| UniProtKB/Swiss-Prot ID
| Q8TDZ2 |
| UniProtKB/Swiss-Prot Entry Name
| MICA1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB048948 |
| GeneCard ID
| MICAL1 |
| GenAtlas ID
| MICAL1 |
| HGNC ID
| HGNC:20619 |
| References |
|---|
| General References
| Not Available |