| Identification |
|---|
| HMDB Protein ID
| CDBP03486 |
| Secondary Accession Numbers
| Not Available |
| Name
| FAD-dependent oxidoreductase domain-containing protein 2 |
| Description
| Not Available |
| Synonyms
|
- Endoplasmic reticulum flavoprotein associated with degradation
|
| Gene Name
| FOXRED2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Endoplasmic reticulum lumen
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q12.3 |
| SNPs
| FOXRED2 |
| Gene Sequence
|
>2055 bp
ATGGGCCTCTCCGCTGCGGCCCCGTTGTGGGGTCCCCCGGGGCTGCTCCTGGCCATCGCC
CTGCACCCAGCGCTGTCGGTGCCCCCGCGCCGGGACTACTGCGTGCTGGGCGCTGGGCCC
GCGGGCCTGCAGATGGCCTACTTCCTGCAGCGCGCTGGACGCGACTACGCAGTGTTCGAG
CGGGCCCCGCGGCCCGGCAGCTTCTTCACACGCTACCCGCGGCACCGCAAGCTCATCAGC
ATCAACAAGCGGTACACGGGCAAGGCTAACGCCGAGTTCAACCTCCGCCACGACTGGAAC
TCTCTGCTCAGCCACGACCCCCGGCTGCTCTTCAGACACTACTCGCGTGCCTACTTCCCC
GACGCCCGCGACATGGTGCGCTACCTGGGTGACTTCGCGGACACGCTGGGGCTCCGTGTC
CAGTACAACACCACCATCGCCCACGTCACTCTGGACAAGGACCGACAGGCCTGGAATGGC
CACTACTTCATCCTAACTGACCAGAAGGGCCAGGTGCATCAGTGCAGCGTCCTCTTTGTA
GCCACTGGTTTATCAGTCCCCAACCAGGTCGACTTCCCTGGCTCCGAATATGCAGAGGGT
TACGAGTCCGTGTCCGTGGACCCTGAGGACTTTGTAGGCCAGAATGTGCTGATCCTGGGT
CGTGGGAACTCGGCCTTTGAGACAGCAGAGAACATCTTGGGTGTCACAAACTTTATCCAT
ATGCTCAGCCGCTCCCGGGTCCGTCTGTCCTGGGCCACCCACTACGTTGGAGACCTCAGA
GCCATCAACAATGGCCTGCTGGATACCTACCAGCTCAAGTCCCTGGACGGGCTGCTCGAG
TCTGACCTGACGGATCTGGCCATCCTGAAGGACAGCAAAGGCAAGTTCCATGTCACCCCG
AAATTCTTCCTGGAAGAAGCCAACACCAACCAGAGTGCCGACTCCATCACCCTCCCCCAG
GACGACAATGACAACTTTGCCATGCGCGTGCCCTATGACCGGGTAATCCGCTGCCTGGGC
TGGAACTTTGACTTCTCCATTTTCAATAAGTCCCTCAGACTTAACTCGGGAAATGCATTC
GGCAAGAAGTACCCGCTGATTCGAGCTAGCTACGAATCCAAAGGAAGCCGGGGTCTGTTT
ATCCTGGGTACTGCCAGCCACTCGGTGGACTACCGGAAATCTGCTGGGGGCTTCATCCAC
GGATTCCGATACACAGTGCGTGCTGTTCACCGGCTCCTGGAGCACCGCCACCACAGCGTC
ACCTGGCCCGCCACTGAGCTCCCCATCACACAGCTGACCAGCTCCATCGTGCGGCGCGTG
AATGAGGCTTCTGGGCTCTACCAGATGTTCGGTGTGCTGGCCGATGTCATCCTGTTGAAG
GAGAATTCCACGGCCTTTGAGTACCTGGAGGAGTTCCCCATACAGATGCTGGCCCAGCTG
GAGACACTCACAGGGAGGAAGGCAAAGCACGGGCTCTTCGTCATCAACATGGAATATGGC
AGAAATTTCTCTGGCCCCGACAAGGACGTCTTCTTTGATGACCGGTCTGTGGGGCACACA
GAAGATGCCTGGCAGTCTAACTTTCTTCATCCTGTCATCTACTACTATAGATACCTCCCC
ACCGAACAGGAGGTGAGGTTCCGCCCTGCACACTGGCCCCTGCCTCGGCCCACGGCCATC
CATCACATCGTGGAAGACTTCTTAACAGACTGGACTGCCCCGATCGGGCACATCCTACCT
CTGAGGCGCTTCCTGGAGAACTGTTTGGACACCGATTTGCGAAGCTTCTATGCAGAGTCC
TGCTTCCTGTTCGCCCTCGCGCGCCAGAAGTTGCCACCCTTTTGCCAGCAGGGGTACCTG
AGGATGCAGGGACTCGTGAGTACCGAGAGCCTTTGGCAGCACAGAGTGGAGAGCAGGCTC
CTGCGGGACTATGCCCCCACAGGCAGGCGCCTGGAGGACAGCAGCCAGCAGCTTGGCGAC
CAAGAGCCACTAGGTTCCCCCCTGGCTCCAGGGCCTCTGGCTCAGTCCGTCGATAGCAAC
AAAGAGGAGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 684 |
| Molecular Weight
| 77790.4 |
| Theoretical pI
| 7.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>FAD-dependent oxidoreductase domain-containing protein 2
MGLSAAAPLWGPPGLLLAIALHPALSVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFE
RAPRPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSLLSHDPRLLFRHYSRAYFP
DARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWNGHYFILTDQKGQVHQCSVLFV
ATGLSVPNQVDFPGSEYAEGYESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFIH
MLSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLESDLTDLAILKDSKGKFHVTP
KFFLEEANTNQSADSITLPQDDNDNFAMRVPYDRVIRCLGWNFDFSIFNKSLRLNSGNAF
GKKYPLIRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEHRHHSV
TWPATELPITQLTSSIVRRVNEASGLYQMFGVLADVILLKENSTAFEYLEEFPIQMLAQL
ETLTGRKAKHGLFVINMEYGRNFSGPDKDVFFDDRSVGHTEDAWQSNFLHPVIYYYRYLP
TEQEVRFRPAHWPLPRPTAIHHIVEDFLTDWTAPIGHILPLRRFLENCLDTDLRSFYAES
CFLFALTRQKLPPFCQQGYLRMQGLVSTESLWQHRVESRLLRDYAPTGRRLEDSSQQLGD
QEPLGSPLAPGPLAQSVDSNKEEL
|
| External Links |
|---|
| GenBank ID Protein
| 10438323 |
| UniProtKB/Swiss-Prot ID
| Q8IWF2 |
| UniProtKB/Swiss-Prot Entry Name
| FXRD2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK025714 |
| GeneCard ID
| FOXRED2 |
| GenAtlas ID
| FOXRED2 |
| HGNC ID
| HGNC:26264 |
| References |
|---|
| General References
| Not Available |