| Identification |
|---|
| HMDB Protein ID
| CDBP03480 |
| Secondary Accession Numbers
| Not Available |
| Name
| tRNA-dihydrouridine synthase 1-like |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| DUS1L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs |
| GO Classification
|
| Function |
| oxidoreductase activity, acting on the ch-ch group of donors |
| binding |
| catalytic activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| oxidoreductase activity |
| fad or fadh2 binding |
| trna dihydrouridine synthase activity |
| Process |
| trna metabolic process |
| trna processing |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| oxidation reduction |
| rna metabolic process |
| ncrna metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q25.3 |
| SNPs
| DUS1L |
| Gene Sequence
|
>1422 bp
ATGCCAAAGCTGCAGGGCTTCGAGTTCTGGAGCCGCACCCTGCGAGGGGCCCGCCACGTC
GTGGCCCCCATGGTGGACCAGAGCGAGCTGGCCTGGAGGCTGCTGAGCCGGCGCCACGGG
GCACAGCTCTGCTACACGCCCATGCTGCATGCCCAGGTCTTTGTCCGCGACGCCAACTAC
CGGAAGGAGAACCTGTACTGCGAGGTGTGCCCCGAGGACCGGCCCCTCATCGTGCAGTTC
TGTGCCAATGACCCGGAGGTGTTTGTTCAGGCGGCTCTCCTGGCTCAGGATTACTGTGAC
GCCATTGACCTGAACTTGGGCTGCCCACAGATGATAGCCAAGAGAGGTCACTATGGCGCC
TTTCTGCAGGACGAGTGGGACCTGCTCCAAAGAATGATTTTGCTGGCCCACGAGAAACTC
TCTGTTCCTGTCACGTGCAAAATCCGTGTCTTCCCGGAGATTGACAAGACCGTGAGGTAC
GCCCAGATGCTGGAGAAGGCCGGCTGCCAGTTGCTGACGGTGCACGGACGCACCAAGGAG
CAGAAGGGGCCCCTGTCGGGTGCAGCGTCCTGGGAGCATATCAAGGCTGTGCGGAAGGCT
GTGGCCATCCCTGTGTTTGCTAACGGGAACATCCAGTGCCTGCAGGACGTGGAGCGCTGC
CTCCGGGACACGGGTGTGCAGGGCGTCATGAGCGCAGAGGGCAACCTGCACAACCCCGCC
CTGTTCGAGGGCCGGAGCCCTGCCGTGTGGGAGCTGGCCGAGGAGTATCTGGACATCGTG
CGGGAGCACCCCTGCCCCCTGTCCTACGTCCGGGCCCACCTCTTCAAGCTGTGGCACCAC
ACGCTGCAGGTGCACCAGGAGCTGCGAGAGGAGCTGGCCAAGGTGAAGACCCTGGAGGGC
ATCGCTGCTGTGAGCCAGGAGCTGAAGCTGCGGTGTCAGGAGGAGATATCCAGGCAGGAG
GGAGCGAAGCCCACCGGCGACTTGCCCTTCCACTGGATCTGCCAGCCCTACATCCGGCCG
GGGCCCAGGGAGGGGAGCAAGGAGAAGGCAGGTGCGCGCAGCAAGCGGGCCCTGGAGGAA
GAGGAGGGTGGCACGGAGGTCCTGTCCAAGAACAAGCAAAAGAAGCAGCTGAGGAACCCC
CACAAGACCTTCGACCCCTCTCTGAAGCCAAAATATGCAAAGTGTGACCAGTGTGGAAAC
CCAAAGGGCAACAGATGTGTGTTCAGCCTGTGCCGCGGCTGCTGCAAGAAGCGAGCCTCC
AAAGAGACTGCAGACTGCCCAGGTCACGGATTGCTTTTTAAAACCAAATTGGAGAAGTCT
CTGGCCTGGAAAGAGGCCCAGCCTGAGCTGCAGGAGCCTCAGCCAGCAGCACCTGGAACA
CCAGGTGGCTTCTCCGAAGTCATGGGCAGTGCCCTGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 473 |
| Molecular Weight
| 53230.0 |
| Theoretical pI
| 8.37 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>tRNA-dihydrouridine synthase 1-like
MPKLQGFEFWSRTLRGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANY
RKENLYCEVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGHYGA
FLQDEWDLLQRMILLAHEKLSVPVTCKIRVFPEIDKTVRYAQMLEKAGCQLLTVHGRTKE
QKGPLSGAASWEHIKAVRKAVAIPVFANGNIQCLQDVERCLRDTGVQGVMSAEGNLHNPA
LFEGRSPAVWELAEEYLDIVREHPCPLSYVRAHLFKLWHHTLQVHQELREELAKVKTLEG
IAAVSQELKLRCQEEISRQEGAKPTGDLPFHWICQPYIRPGPREGSKEKAGARSKRALEE
EEGGTEVLSKNKQKKQLRNPHKTFDPSLKPKYAKCDQCGNPKGNRCVFSLCRGCCKKRAS
KETADCPGHGLLFKTKLEKSLAWKEAQPELQEPQPAAPGTPGGFSEVMGSALA
|
| External Links |
|---|
| GenBank ID Protein
| 40807366 |
| UniProtKB/Swiss-Prot ID
| Q6P1R4 |
| UniProtKB/Swiss-Prot Entry Name
| DUS1L_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_022156.3 |
| GeneCard ID
| DUS1L |
| GenAtlas ID
| DUS1L |
| HGNC ID
| HGNC:30086 |
| References |
|---|
| General References
| Not Available |