| Identification |
|---|
| HMDB Protein ID
| CDBP03478 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lysine-specific histone demethylase 1B |
| Description
| Not Available |
| Synonyms
|
- Flavin-containing amine oxidase domain-containing protein 1
- Lysine-specific histone demethylase 2
|
| Gene Name
| KDM1B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p22.3 |
| SNPs
| KDM1B |
| Gene Sequence
|
>2475 bp
ATGGCAACCCCACGGGGGAGGACAAAGAAAAAAGCATCTTTTGATCATTCTCCGGATAGC
CTTCCTTTGAGGAGCTCCGGTAGGCAGGTAGTGGCGAAGAAGAAAGCAACAGAGACAACA
GATGAGGATGAAGATGGTGGGTCAGAGAAGAAGTACAGGAAATGTGAAAAGGCAGGCTGT
ACGGCAACATGTCCTGTGTGCTTTGCGAGTGCTTCTGAAAGATGTGCCAAAAATGGCTAC
ACCTCCCGATGGTATCATCTCTCCTGTGGGGAACATTTCTGTAATGAATGCTTTGACCAT
TACTACAGAAGCCATAAGGATGGATATGACAAATATACTACATGGAAAAAAATATGGACT
AGCAATGGCAAAACTGAACCTAGTCCCAAAGCTTTCATGGCAGACCAGCAACTCCCCTAC
TGGGTTCAGTGTACAAAACCTGAGTGTAGAAAATGGAGGCAGCTTACCAAGGAAATCCAG
CTTACTCCACAGATAGCCAAGACTTATCGATGTGGTATGAAACCAAATACTGCTATTAAG
CCTGAGACCTCAGATCATTGTTCCCTTCCAGAGGATCTAAGAGTATTGGAAGTTTCCAAC
CATTGGTGGTACTCTATGCTCATCCTACCTCCTTTGCTGAAAGACAGCGTGGCAGCGCCC
CTGCTGTCTGCCTACTACCCCGACTGTGTTGGCATGAGCCCCTCCTGCACCAGCACAAAC
CGTGCCGCTGCCATTGGCGATGCCAGCCCTGGGAAGCTGGAGCACTCCAAGGCTGCCCTC
TCCGTGCACGTTCCAGGCATGAACCGATACTTCCAGCCTTTCTACCAGCCCAATGAGTGT
GGCAAAGCCCTCTGTGTGAGGCCGGATGTGATGGAACTGGATGAGCTCTATGAGTTTCCA
GAGTATTCCCGAGACCCCACCATGTACCTGGCTTTGAGAAACCTCATCCTCGCACTGTGG
TATACTAACTGCAAAGAAGCTCTTACTCCTCAGAAATGTATTCCTCACATCATCGTCCGG
GGTCTTGTGCGTATTCGATGCGTTCAGGAAGTGGAGAGAATACTGTATTTTATGACCAGA
AAAGGTCTCATCAACACTGGAGTTCTCAGCGTGGGAGCCGACCAGTATCTTCTCCCTAAG
GACTACCACAATAAATCAGTCATCATTATCGGGGCTGGTCCCGCAGGATTAGCAGCTGCT
AAGCAACTGCATAACTTTGGAATTAAGGTGACTGTCCTGGAAGCCAAAGACAGAATTGGA
GGCCGAGTCTGGGATGATAAATCTTTTAAAGGCGTCACAGTGGGAAGAGGAGCTCAGATT
GTCAATGGGTGTATTAACAACCCAGTAGCATTAATGTGTGAGCAACTTGGCATCAGCATG
CATAAATTTGGAGAAAGATGTGACTTAATTCAGGAAGGTGGAAGAATAACTGACCCCACT
ATTGACAAGCGCATGGATTTTCATTTTAATGCTCTCTTGGATGTTGTCTCTGAGTGGAGA
AAGGATAAGACTCAGCTCCAAGATGTCCCTTTAGGAGAAAAGATAGAAGAGATCTACAAG
GCATTTATTAAGGAATCTGGTATCCAATTCAGTGAGCTGGAGGGACAGGTGCTTCAGTTC
CATCTCAGTAACCTGGAGTACGCCTGTGGCAGCAACCTTCACCAGGTATCTGCTCGCTCC
TGGGACCACAATGAATTCTTTGCCCAGTTTGCTGGTGACCACACTCTGCTAACTCCCGGG
TACTCAGTGATAATTGAAAAACTGGCAGAAGGGCTCGACATTCGACTCAAATCTCCAGTG
CAGTGTATTGATTATTCTGGAGGTGAAGTGCAGGTTACCACTACAGATGGCACAGGGTAT
TCTGCACAAAAGGTATTAGTCACTGTACCACTGGCTTTACTACAGAAAGGTGCCATTCAG
TTTAATCCACCATTATCAGAGAAGAAGATGAAGGCTATCAACAGCTTAGGCGCAGGCATC
ATTGAAAAGATTGCCTTGCAATTTCCATATAGATTTTGGGACAGTAAAGTTCAAGGGGCT
GACTTTTTTGGTCACGTTCCTCCCAGTGCCAGCAAGCGAGGGCTTTTTGCCGTGTTCTAT
GATATGGATCCCCAGAAGAAGCACAGCGTGCTGATGTCTGTGATTGCCGGGGAGGCTGTC
GCGTCCGTGAGGACCCTGGAAGACAAACAGGTGCTGCAGCAGTGCATGGCCACGCTCCGG
GAGCTGTTCAAGGAGCAGGAGGTCCCAGATCCCACAAAGTATTTTGTCACTCGGTGGAGC
ACAGACCCATGGATCCAGATGGCATACAGTTTTGTGAAGACAGGTGGAAGTGGGGAGGCC
TATGATATCATTGCTGAAGACATTCAAGGAACCGTCTTTTTCGCTGGTGAGGCAACAAAC
AGGCATTTCCCACAAACTGTTACAGGGGCATATTTGAGTGGCGTTCGAGAAGCAAGCAAG
ATTGCAGCATTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 823 |
| Molecular Weight
| 92225.7 |
| Theoretical pI
| 7.93 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Lysine-specific histone demethylase 1B
MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTA
TCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSN
GKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPE
TSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRA
AATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEY
SRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKG
LINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGR
VWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTID
KRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHL
SNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPQVQ
CIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGII
EKIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVA
SVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAY
DIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
|
| External Links |
|---|
| GenBank ID Protein
| 297677229 |
| UniProtKB/Swiss-Prot ID
| Q8NB78 |
| UniProtKB/Swiss-Prot Entry Name
| KDM1B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| XM_002816464 |
| GeneCard ID
| KDM1B |
| GenAtlas ID
| KDM1B |
| HGNC ID
| HGNC:21577 |
| References |
|---|
| General References
| Not Available |