| Identification |
|---|
| HMDB Protein ID
| CDBP03477 |
| Secondary Accession Numbers
| Not Available |
| Name
| FAD-linked sulfhydryl oxidase ALR |
| Description
| Not Available |
| Synonyms
|
- Augmenter of liver regeneration
- Hepatopoietin
- hERV1
|
| Gene Name
| GFER |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in thiol oxidase activity |
| Specific Function
| Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs.
Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
|
| GO Classification
|
| Biological Process |
| spermatogenesis |
| cell proliferation |
| cellular protein metabolic process |
| protein targeting to mitochondrion |
| Cellular Component |
| mitochondrion |
| extracellular region |
| mitochondrial intermembrane space |
| Function |
| catalytic activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor |
| thiol oxidase activity |
| oxidoreductase activity |
| Molecular Function |
| thiol oxidase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p13.3-p13.12 |
| SNPs
| GFER |
| Gene Sequence
|
>618 bp
ATGGCGGCGCCCGGCGAGCGGGGCCGCTTCCACGGCGGGAACCTCTTCTTCCTGCCGGGG
GGCGCGCGCTCCGAGATGATGGACGACCTGGCGACCGACGCGCGGGGCCGGGGCGCGGGG
CGGAGAGACGCGGCCGCCTCGGCCTCGACGCCAGCCCAGGCGCCGACCTCCGATTCTCCT
GTCGCCGAGGACGCCTCCCGGAGGCGGCCGTGCCGGGCCTGCGTCGACTTCAAGACGTGG
ATGCGGACGCAGCAGAAGCGGGACACCAAGTTTAGGGAGGACTGCCCGCCGGATCGCGAG
GAACTGGGCCGCCACAGCTGGGCTGTCCTCCACACCCTGGCCGCCTACTACCCCGACCTG
CCCACCCCAGAACAGCAGCAAGACATGGCCCAGTTCATACATTTATTTTCTAAGTTTTAC
CCCTGTGAGGAGTGTGCTGAAGACCTAAGAAAAAGGCTGTGCAGGAACCACCCAGACACC
CGCACCCGGGCATGCTTCACACAGTGGCTGTGCCACCTGCACAATGAAGTGAACCGCAAG
CTGGGCAAGCCTGACTTCGACTGCTCAAAAGTGGATGAGCGCTGGCGCGACGGCTGGAAG
GATGGCTCCTGTGACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 205 |
| Molecular Weight
| 23448.95 |
| Theoretical pI
| 7.621 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>FAD-linked sulfhydryl oxidase ALR
MAAPGERGRFHGGNLFFLPGGARSEMMDDLATDARGRGAGRRDAAASASTPAQAPTSDSP
VAEDASRRRPCRACVDFKTWMRTQQKRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDL
PTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRACFTQWLCHLHNEVNRK
LGKPDFDCSKVDERWRDGWKDGSCD
|
| External Links |
|---|
| GenBank ID Protein
| 54112432 |
| UniProtKB/Swiss-Prot ID
| P55789 |
| UniProtKB/Swiss-Prot Entry Name
| ALR_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_005262.2 |
| GeneCard ID
| GFER |
| GenAtlas ID
| GFER |
| HGNC ID
| HGNC:4236 |
| References |
|---|
| General References
| Not Available |