Showing Protein Apoptosis-inducing factor 3 (CDBP03476)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03476
Secondary Accession Numbers Not Available
Name Apoptosis-inducing factor 3
Description Not Available
Synonyms
  1. Apoptosis-inducing factor-like protein
Gene Name AIFM3
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential
GO Classification
Component
cell part
intracellular part
cytoplasm
Function
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
metal cluster binding
iron-sulfur cluster binding
2 iron, 2 sulfur cluster binding
oxidoreductase activity
fad or fadh2 binding
Process
metabolic process
cellular process
oxidation reduction
cellular homeostasis
cell redox homeostasis
Cellular Location
  1. Mitochondrion
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 22q11.21
SNPs AIFM3
Gene Sequence 
>1818 bp
ATGGGCGGCTGCTTCTCCAAACCCAAACCAGTGGAGCTCAAGATCGAGGTGGTGCTGCCT
GAGAAGGAGCGAGGCAAGGAGGAGCTGTCGGCCAGTGGGAAGGGCAGCCCCCGGGCCTAC
CAGGGCAATGGCACGGCCCGCCACTTCCACACGGAGGAGCGCCTGTCCACCCCTCACCCC
TACCCCAGCCCTCAGGATTGCGTGGAGGCTGCTGTCTGCCACGTCAAGGACCTCGAGAAT
GGCCAGATGCGGGAAGTGGAGCTGGGCTGGGGGAAGGTGTTGCTGGTGAAGGACAATGGG
GAGTTCCACGCCCTGGGCCATAAGTGTCCGCACTACGGCGCACCCCTGGTGAAAGGCGTT
CTGTCCCGTGGTCGGGTGCGCTGCCCCTGGCACGGCGCCTGCTTCAACATCAGCACTGGG
GACCTGGAGGACTTCCCTGGCCTGGACAGTCTACACAAGTTCCAGGTGAAGATTGAGAAG
GAGAAGGTGTACGTCCGGGCCAGCAAGCAGGCCCTACAGCTGCAGCGAAGGACCAAGGTG
ATGGCCAAGTGTATCTCTCCAAGTGCTGGGTACAGCAGTAGCACCAATGTGCTCATTGTG
GGTGCAGGTGCAGCTGGCCTGGTGTGTGCAGAGACACTGCGGCAGGAGGGCTTCTCCGAC
CGGATCGTCCTGTGCACGCTAGACCGGCACCTTCCCTACGACCGTCCCAAGCTCAGCAAG
TCCCTGGACACACAGCCTGAGCAGCTGGCCCTGAGGCCCAAGGAGTTTTTCCGAGCCTAT
GGCATCGAGGTGCTCACCGAGGCTCAGGTGGTCACAGTGGACGTGAGAACTAAGAAGGTC
GTGTTCAAGGATGGCTTCAAGCTGGAGTACAGCAAGCTGCTGCTGGCACCAGGGAGCAGC
CCCAAGACTCTGAGCTGCAAAGGCAAAGAAGTGGAGAACGTGTTCACTATCCGGACGCCA
GAGGATGCCAATCGCGTGGTGAGGCTGGCCCGAGGCCGCAACGTGGTCGTCGTGGGAGCC
GGCTTCCTGGGGATGGAGGTGGCCGCTTACCTGACGGAGAAGGCCCACTCTGTGTCTGTG
GTGGAGCTGGAGGAGACGCCCTTCAGGAGGTTCCTGGGGGAGCGCGTGGGTCGTGCCCTC
ATGAAGATGTTTGAGAACAACCGGGTGAAGTTCTACATGCAGACGGAGGTGTCTGAGCTG
CGGGGCCAGGAGGGAAAGCTGAAGGAGGTTGTGCTGAAGAGCAGCAAGGTCGTGCGGGCT
GACGTCTGCGTGGTGGGCATTGGTGCAGTGCCCGCCACAGGCTTCCTGAGGCAAAGCGGC
ATCGGTTTGGATTCCCGAGGCTTCATCCCTGTCAACAAGATGATGCAGACCAATGTCCCA
GGCGTGTTTGCAGCTGGCGATGCTGTCACCTTCCCCCTTGCCTGGAGGAACAACCGCAAA
GTGAACATTCCACATTGGCAGATGGCTCATGCTCAGGGGCGCGTGGCAGCCCAGAACATG
TTGGCGCAGGAGGCGGAGATGAGCACTGTGCCCTACCTCTGGACCGCCATGTTTGGCAAG
AGCCTGCGCTACGCGGGCTACGGAGAAGGCTTCGACGACGTCATCATCCAGGGGGATCTG
GAGGAGCTGAAGTTTGTGGCTTTTTACACTAAAGGCGACGAGGTGATCGCCGTGGCCAGC
ATGAACTACGATCCCATTGTGTCCAAGGTCGCTGAGGTGCTGGCCTCAGGCCGTGCCATC
CGGAAGCGGGAGGTGGAGCTGTTTGTGCTGCACAGCAAGACTGGCGACATGTCCTGGCTT
ACGGGGAAAGGATCCTGA
Protein Properties
Number of Residues 605
Molecular Weight 66790.7
Theoretical pI 9.49
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Apoptosis-inducing factor 3
MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHP
YPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGV
LSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKV
MAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSK
SLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSS
PKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSV
VELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRA
DVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRK
VNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDL
EELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKTGDMSWL
TGKGS
GenBank ID Protein 21389617
UniProtKB/Swiss-Prot ID Q96NN9
UniProtKB/Swiss-Prot Entry Name AIFM3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_144704.2
GeneCard ID AIFM3
GenAtlas ID AIFM3
HGNC ID HGNC:26398
References
General References Not Available