| Identification |
|---|
| HMDB Protein ID
| CDBP03460 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ecto-NOX disulfide-thiol exchanger 1 |
| Description
| Not Available |
| Synonyms
|
- Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase
- Cell proliferation-inducing gene 38 protein
- Constitutive Ecto-NOX
- Hydroquinone [NADH] oxidase
- Protein disulfide-thiol oxidoreductase
- cCNOX
- cNOX
|
| Gene Name
| ENOX1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock |
| GO Classification
|
| Function |
| binding |
| nucleotide binding |
| nucleic acid binding |
|
| Cellular Location
|
- Cell membrane
- Secreted
- extracellular space
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q14.11 |
| SNPs
| ENOX1 |
| Gene Sequence
|
>1932 bp
ATGGTAGATGCAGGTGGAGTTGAGAACATCACCCAGCTTCCCCAGGAGCTTCCTCAGATG
ATGGCTGCAGCAGCCGATGGTTTGGGGAGTATAGCGATAGACACGACCCAGCTCAACATG
TCCGTGACAGATCCCACAGCCTGGGCTACAGCCATGAATAACCTGGGCATGGTTCCCGTA
GGGTTGCCTGGACAGCAGCTCGTGTCTGACTCAATCTGTGTCCCAGGCTTTGATCCAAGC
CTCAACATGATGACTGGAATCACCCCCATTAACCCAATGATACCAGGCCTTGGACTGGTA
CCTCCCCCACCACCAACAGAAGTGGCTGTTGTCAAAGAAATAATCCACTGCAAAAGCTGT
ACTCTTTTTCCTCAAAATCCAAATCTTCCACCTCCTTCCACAAGAGAACGACCTCCTGGG
TGTAAGACCGTGTTTGTCGGAGGATTACCAGAAAATGCTACTGAGGAAATTATTCAAGAA
GTCTTTGAACAGTGCGGTGATATTACAGCAATTCGGAAAAGCAAGAAGAATTTTTGTCAC
ATTCGCTTTGCAGAGGAATTCATGGTTGATAAAGCCATTTACCTTTCTGGTTATAGGATG
CGATTAGGGTCTAGCACCGACAAAAAGGATTCAGGCCGCCTTCATGTGGACTTTGCCCAG
GCCAGGGATGACTTCTATGAGTGGGAATGCAAGCAGAGGATGCGTGCCCGGGAGGAGCGG
CACCGGCGCAAGCTGGAGGAGGACCGGCTCAGGCCCCCATCCCCGCCTGCCATAATGCAC
TACTCGGAGCACGAAGCCGCTCTGCTGGCTGAAAAGCTGAAAGATGATAGCAAGTCTTCA
GAGGCTATCACAGTGCTGCTTTCCTGGATTGAACGAGGGGAAGTGAATCGGCGCTCTGCA
AACCAGTTCTATTCCATGGTGCAGTCGGCCAACAGCCACGTCCGCCGGCTAATGAATGAA
AAAGCCACCCATGAGCAAGAGATGGAGGAAGCCAAGGAGAATTTTAAAAATGCCTTAACT
GGGATTCTCACTCAATTTGAGCAGATTGTGGCCGTTTTCAACGCTTCTACCAGACAAAAA
GCTTGGGACCATTTCTCGAAAGCCCAGCGCAAGAACATAGACATTTGGCGAAAGCATTCT
GAGGAGCTCCGGAATGCTCAAAGTGAGCAGCTCATGGGCATCCGCCGCGAAGAAGAAATG
GAAATGTCTGATGATGAGAACTGTGACAGCCCTACAAAGAAAATGAGAGTCGATGAATCA
GCCCTGGCTGCCCAGGCCTACGCTCTGAAAGAGGAGAATGACAGTCTCCGCTGGCAGCTG
GATGCCTACAGGAATGAGGTGGAGCTGCTGAAACAAGAAAAAGAACAGCTTTTCCGAACA
GAAGAAAACCTCACCAAGGACCAGCAACTGCAGTTTCTGCAGCAAACCATGCAAGGCATG
CAGCAGCAATTGCTAACCATCCAGGAGGAGTTAAACAACAAAAAGTCAGAATTGGAACAA
GCAAAGGAAGAGCAGTCCCATACACAAGCGTTACTAAAAGTCCTGCAGGAACAATTAAAA
GGTACCAAGGAATTGGTCGAGACCAATGGCCACAGCCATGAGGATTCAAATGAAATCAAT
GTGTTGACAGTTGCATTAGTCAACCAAGACCGAGAGAACAATATTGAGAAAAGAAGCCAA
GGCTTAAAATCAGAGAAAGAAGCTCTGCTAATAGGTATCATATCAACGTTTCTTCACGTC
CATCCTTTTGGAGCCAACATAGAATATCTTTGGTCATACATGCAGCAGCTGGACTCCAAG
ATATCTGCAAATGAAATAGAAATGCTTTTGATGAGGCTGCCACGCATGTTCAAACAGGAA
TTCACGGGTGTGGGAGCCACGCTGGAAAAAAGATGGAAGTTGTGTGCCTTTGAAGGAATT
AAAACCACCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 643 |
| Molecular Weight
| 73347.8 |
| Theoretical pI
| 5.25 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ecto-NOX disulfide-thiol exchanger 1
MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV
GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC
TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH
IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER
HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA
NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK
AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES
ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM
QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN
VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK
ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT
|
| External Links |
|---|
| GenBank ID Protein
| 7021942 |
| UniProtKB/Swiss-Prot ID
| Q8TC92 |
| UniProtKB/Swiss-Prot Entry Name
| ENOX1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK000956 |
| GeneCard ID
| ENOX1 |
| GenAtlas ID
| ENOX1 |
| HGNC ID
| HGNC:25474 |
| References |
|---|
| General References
| Not Available |