| Identification |
|---|
| HMDB Protein ID
| CDBP03447 |
| Secondary Accession Numbers
| Not Available |
| Name
| Methionine aminopeptidase 1 |
| Description
| Not Available |
| Synonyms
|
- MAP 1
- MetAP 1
- Peptidase M 1
|
| Gene Name
| METAP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in aminopeptidase activity |
| Specific Function
| Removes the amino-terminal methionine from nascent proteins. Required for normal progression through the cell cycle |
| GO Classification
|
| Function |
| peptidase activity, acting on l-amino acid peptides |
| metallopeptidase activity |
| metalloexopeptidase activity |
| exopeptidase activity |
| aminopeptidase activity |
| catalytic activity |
| hydrolase activity |
| peptidase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| cellular process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q23 |
| SNPs
| METAP1 |
| Gene Sequence
|
>1161 bp
ATGGCGGCCGTGGAGACGCGGGTGTGCGAGACAGACGGCTGCAGCAGTGAGGCCAAGCTC
CAGTGTCCCACTTGCATCAAGCTGGGCATCCAGGGCTCGTACTTCTGCTCGCAGGAATGT
TTTAAAGGAAGTTGGGCTACTCACAAGTTACTACATAAGAAAGCAAAAGATGAAAAGGCG
AAGCGAGAAGTGTCTTCCTGGACTGTGGAAGGTGATATTAATACTGACCCATGGGCAGGT
TATCGATATACTGGTAAACTCAGACCACATTATCCACTGATGCCAACAAGGCCAGTGCCA
AGTTATATTCAAAGACCAGATTATGCTGATCATCCCTTAGGAATGTCTGAATCTGAACAG
GCTCTTAAAGGTACTTCTCAGATTAAATTACTCTCATCTGAAGATATAGAAGGGATGCGA
CTTGTATGTAGGCTTGCTAGAGAAGTTTTGGATGTTGCTGCCGGCATGATTAAACCAGGT
GTAACTACTGAAGAAATAGATCACGCTGTACACTTAGCATGTATTGCAAGAAATTGCTAC
CCTTCTCCCCTGAATTATTATAATTTCCCAAAGTCTTGTTGTACCTCAGTGAATGAAGTC
ATTTGCCATGGAATACCAGACAGAAGGCCCTTACAAGAAGGTGACATTGTTAATGTGGAT
ATCACTCTTTATCGCAATGGTTATCATGGGGACCTGAATGAGACATTTTTTGTTGGAGAA
GTGGATGATGGAGCACGGAAACTTGTTCAGACCACATATGAGTGCCTGATGCAAGCCATT
GATGCAGTGAAGCCTGGTGTTCGGTACAGAGAATTGGGAAACATTATCCAGAAGCATGCC
CAAGCAAATGGGTTTTCAGTTGTTCGAAGCTATTGTGGGCATGGAATCCACAAGCTTTTT
CATACAGCTCCCAATGTACCCCACTATGCTAAAAATAAAGCAGTTGGAGTGATGAAGTCG
GGCCATGTATTTACAATTGAGCCAATGATTTGTGAAGGCGGATGGCAGGATGAAACCTGG
CCAGATGGTTGGACTGCGGTGACAAGAGACGGAAAGCGGTCTGCTCAGTTTGAGCACACC
CTCCTGGTCACAGACACTGGCTGTGAAATCCTAACCCGGCGACTTGACAGTGCACGGCCT
CACTTCATGTCTCAATTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 386 |
| Molecular Weight
| 43214.9 |
| Theoretical pI
| 7.18 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Methionine aminopeptidase 1
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
|
| External Links |
|---|
| GenBank ID Protein
| 194385462 |
| UniProtKB/Swiss-Prot ID
| P53582 |
| UniProtKB/Swiss-Prot Entry Name
| AMPM1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK304239 |
| GeneCard ID
| METAP1 |
| GenAtlas ID
| METAP1 |
| HGNC ID
| HGNC:15789 |
| References |
|---|
| General References
| Not Available |