| Identification |
|---|
| HMDB Protein ID
| CDBP03442 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein tweety homolog 1 |
| Description
| Not Available |
| Synonyms
|
- hTTY1
|
| Gene Name
| TTYH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| Isoform 3 may be a Ca(2+)-independent and swelling- activated chloride channel, possibly involved in regulation of cell volume |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.4 |
| SNPs
| TTYH1 |
| Gene Sequence
|
>1353 bp
ATGGGGGCGCCCCCGGGCTACCGGCCCTCAGCTTGGGTGCATCTCCTCCACCAGCTGCCC
CGCGCCGACTTCCAGCTCCGCCCGGTGCCCAGCGTTTTCGCGCCCCAAGAGCAGGAATAC
CAGCAGGCCTTGTTGCTGGTGGCGGCCTTGGCGGGCCTGGGCTTGGGCCTGAGCCTCATT
TTCATCGCTGTCTACCTCATCCGCTTCTGCTGCTGCCGGCCCCCCGAGCCCCCCGGGTCC
AAGATCCCCTCGCCCGGGGGAGGCTGCGTCACCTGGAGCTGCATTGTCGCCCTTCTCGCC
GGCTGCACTGGCATTGGCATCGGTTTCTATGGCAACAGTGAGACCAGTGATGGGGTGTCC
CAGCTCAGCTCTGCGCTGCTGCACGCCAACCACACACTCAGCACCATTGACCACCTGGTG
TTGGAGACGGTGGAGAGGCTGGGCGAGGCGGTGAGGACAGAGCTGACCACCCTGGAGGAG
GTGCTCGAGCCGCGCACGGAGCTGGTGGCTGCCGCCCGAGGGGCTCGACGGCAGGCGGAG
GCTGCGGCCCAGCAGCTGCAGGGGCTGGCCTTCTGGCAGGGAGTGCCCCTGAGCCCCCTG
CAGGTGGCTGAAAATGTGTCCTTTGTGGAGGAGTACAGGTGGCTGGCCTACGTCCTCCTG
CTGCTCCTGGAGCTGCTGGTCTGCCTCTTCACCCTCCTGGGCCTGGCGAAGCAGAGCAAG
TGGCTGGTGATCGTGATGACAGTCATGAGTCTCCTGGTTCTCGTCCTGAGCTGGGGCTCC
ATGGGCCTGGAGGCAGCCACGGCCGTGGGCCTCAGTGACTTCTGCTCCAATCCAGACCCT
TATGTTCTGAACCTGACCCAGGAGGAGACAGGGCTCAGCTCAGACATCCTGAGCTATTAT
CTCCTCTGCAACCGGGCCGTCTCCAACCCCTTCCAACAGAGGCTGACTCTGTCCCAGCGA
GCTCTGGCCAACATCCACTCCCAGCTGCTGGGCCTGGAGCGAGAAGCTGTGCCTCAGTTC
CCTTCAGCGCAGAAGCCTCTGCTGTCCTTGGAGGAGACTCTGAATGTGACAGAAGGAAAT
TTCCACCAGTTGGTGGCACTGCTACACTGCCGCAGCCTGCACAAGGACTATGGTGCAGCC
CTGCGGGGCCTGTGCGAAGACGCCCTGGAAGGCCTGCTCTTCCTGCTACTCTTCTCCCTG
CTGTCTGCAGGAGCGCTGGCCACTGCCCTCTGCAGCCTGCCCCGAGCCTGGGCCCTCTTC
CCACCCAGTGACGACTACGATGACACAGACGATGACGACCCTTTCAACCCTCAGGAATCC
AAGCGCTTTGTGCAGTGGCAGTCGTCTATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 450 |
| Molecular Weight
| 49050.0 |
| Theoretical pI
| 4.62 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["44-64", "89-109", "215-235", "241-261", "391-411"]
|
| Protein Sequence
|
>Protein tweety homolog 1
MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLI
FIAVYLIRFCCCRPPEPPGSKIPSPGGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVS
QLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTELVAAARGARRQAE
AAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSK
WLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEETGLSSDILSYY
LLCNRAVSNPFQQRLTLSQRALANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGN
FHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALF
PPSDDYDDTDDDDPFNPQESKRFVQWQSSI
|
| External Links |
|---|
| GenBank ID Protein
| 10257437 |
| UniProtKB/Swiss-Prot ID
| Q9H313 |
| UniProtKB/Swiss-Prot Entry Name
| TTYH1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020659.2 |
| GeneCard ID
| TTYH1 |
| GenAtlas ID
| TTYH1 |
| HGNC ID
| HGNC:13476 |
| References |
|---|
| General References
| Not Available |