| Identification |
|---|
| HMDB Protein ID
| CDBP03436 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADPH oxidase 3 |
| Description
| Not Available |
| Synonyms
|
- GP91-3
- MOX-2
- Mitogenic oxidase 2
- gp91phox homolog 3
|
| Gene Name
| NOX3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| oxidoreductase activity |
| fad or fadh2 binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| electron carrier activity |
| iron ion binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Tyrosine Metabolism |    |  | | Thyroid hormone synthesis |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q25.3 |
| SNPs
| NOX3 |
| Gene Sequence
|
>1707 bp
ATGATGGGGTGCTGGATTTTGAATGAGGGTCTCTCCACCATATTAGTACTCTCATGGCTG
GGAATAAATTTTTATCTGTTTATTGACACGTTCTACTGGTATGAAGAGGAGGAGTCTTTC
CATTACACACGAGTTATTTTGGGTTCAACACTGGCTTGGGCACGAGCATCCGCACTGTGC
CTGAATTTTAACTGCATGCTAATTCTAATACCTGTCAGTCGAAACCTTATTTCATTCATA
AGAGGAACAAGTATTTGCTGCAGAGGACCGTGGAGGAGGCAATTAGACAAAAACCTCAGA
TTTCACAAACTGGTCGCCTATGGGATAGCTGTTAATGCAACCATCCACATCGTGGCGCAT
TTCTTCAACCTGGAACGCTACCACTGGAGCCAGTCCGAGGAGGCCCAGGGACTTCTGGCC
GCACTTTCCAAGCTGGGCAACACCCCTAACGAGAGCTACCTCAACCCTGTCCGGACCTTC
CCCACAAACACAACCACTGAATTGCTAAGGACAATAGCAGGCGTCACCGGTCTGGTGATC
TCTCTGGCTTTAGTCTTGATCATGACCTCGTCAACTGAGTTCATCAGACAGGCCTCCTAT
GAGTTGTTCTGGTACACACACCATGTTTTCATCGTCTTCTTTCTCAGCCTGGCCATCCAT
GGGACGGGTCGGATTGTTCGAGGCCAAACCCAAGACAGTCTCTCTCTGCACAACATCACC
TTCTGTAGAGACCGCTATGCAGAATGGCAGACAGTGGCCCAATGCCCCGTGCCTCAATTT
TCTGGCAAGGAACCCTCGGCTTGGAAATGGATTTTAGGCCCTGTGGTCTTGTATGCATGT
GAAAGAATAATTAGGTTCTGGCGATTTCAACAAGAAGTTGTCATTACCAAGGTGGTAAGC
CACCCCTCTGGAGTCCTGGAACTTCACATGAAAAAGCGTGGCTTTAAAATGGCGCCAGGG
CAGTACATCTTGGTGCAGTGCCCAGCCATATCTTCGCTGGAGTGGCACCCCTTCACCCTT
ACCTCTGCCCCCCAGGAAGACTTTTTCAGCGTGCACATCCGGGCAGCAGGAGACTGGACA
GCAGCGCTACTGGAGGCCTTTGGGGCAGAGGGACAGGCCCTCCAGGAGCCCTGGAGCCTG
CCAAGGCTGGCAGTGGACGGGCCCTTTGGAACTGCCCTGACAGATGTATTTCACTACCCA
GTGTGTGTGTGCGTTGCCGCGGGGATCGGAGTCACTCCCTTCGCTGCTCTTCTGAAATCT
ATATGGTACAAATGCAGTGAGGCACAGACCCCACTGAAGCTGAGCAAGGTGTATTTCTAC
TGGATTTGCCGGGATGCAAGAGCTTTTGAGTGGTTTGCTGATCTCTTACTCTCCCTGGAA
ACACGGATGAGTGAGCAGGGGAAAACTCACTTTCTGAGTTATCATATATTTCTTACCGGC
TGGGATGAAAATCAGGCTCTTCACATAGCTTTACACTGGGACGAAAATACTGACGTGATT
ACAGGCTTAAAGCAGAAGACCTTCTATGGGAGGCCCAACTGGAACAATGAGTTCAAGCAG
ATTGCCTACAATCACCCCAGCAGCAGTATTGGCGTGTTCTTCTGTGGACCTAAAGCTCTC
TCGAGGACACTTCAAAAGATGTGCCACTTGTATTCATCAGCTGACCCCAGAGGTGTTCAT
TTCTATTACAACAAGGAGAGCTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 568 |
| Molecular Weight
| 64934.3 |
| Theoretical pI
| 8.07 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["14-34", "52-72", "104-124", "168-188", "202-222", "396-416"]
|
| Protein Sequence
|
>NADPH oxidase 3
MMGCWILNEGLSTILVLSWLGINFYLFIDTFYWYEEEESFHYTRVILGSTLAWARASALC
LNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFHKLVAYGIAVNATIHIVAH
FFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTFPTNTTTELLRTIAGVTGLVI
SLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLAIHGTGRIVRGQTQDSLSLHNIT
FCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVVLYACERIIRFWRFQQEVVITKVVS
HPSGVLELHMKKRGFKMAPGQYILVQCPAISSLEWHPFTLTSAPQEDFFSVHIRAAGDWT
AALLEAFGAEGQALQEPWSLPRLAVDGPFGTALTDVFHYPVCVCVAAGIGVTPFAALLKS
IWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQGKTHFLSYHIFLTG
WDENQALHIALHWDENTDVITGLKQKTFYGRPNWNNEFKQIAYNHPSSSIGVFFCGPKAL
SRTLQKMCHLYSSADPRGVHFYYNKESF
|
| External Links |
|---|
| GenBank ID Protein
| 10441613 |
| UniProtKB/Swiss-Prot ID
| Q9HBY0 |
| UniProtKB/Swiss-Prot Entry Name
| NOX3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF190122 |
| GeneCard ID
| NOX3 |
| GenAtlas ID
| NOX3 |
| HGNC ID
| HGNC:7890 |
| References |
|---|
| General References
| Not Available |