| Identification |
|---|
| HMDB Protein ID
| CDBP03434 |
| Secondary Accession Numbers
| Not Available |
| Name
| Golgi-associated PDZ and coiled-coil motif-containing protein |
| Description
| Not Available |
| Synonyms
|
- CFTR-associated ligand
- Fused in glioblastoma
- PDZ protein interacting specifically with TC10
- PIST
|
| Gene Name
| GOPC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
- Cytoplasm
- Golgi apparatus membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Golgi apparatus
- trans-Golgi network membrane
- Cell junction
- Cell junction
- synapse
- synapse
- Cell projection
- postsynaptic cell membrane
- postsynaptic density
- dendrite
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q21 |
| SNPs
| GOPC |
| Gene Sequence
|
>1389 bp
ATGTCGGCGGGCGGTCCATGCCCAGCAGCAGCCGGAGGGGGCCCAGGGGGCGCCTCCTGC
TCCGTGGGGGCCCCTGGCGGGGTATCCATGTTCCGGTGGCTGGAGGTGCTGGAGAAGGAG
TTCGACAAAGCTTTTGTGGATGTGGATCTGCTCCTGGGAGAGATCGATCCAGACCAAGCG
GACATCACTTATGAGGGGCGACAGAAGATGACCAGCCTGAGCTCCTGCTTTGCACAGCTT
TGCCACAAAGCCCAGTCTGTGTCTCAAATCAACCACAAGCTGGAGGCACAGTTGGTGGAT
CTGAAATCTGAACTGACAGAAACCCAAGCAGAGAAAGTTGTTTTGGAGAAAGAAGTACAT
GATCAGCTTTTACAGCTGCACTCTATTCAGCTGCAGCTTCATGCTAAAACTGGTCAAAGT
GCTGACTCTGGTACCATTAAGGCAAAATTGTCTGGCCCCTCTGTGGAGGAGCTGGAAAGA
GAGCTTGAGGCAAACAAAAAAGAAAAAATGAAAGAAGCACAACTTGAAGCTGAAGTGAAA
TTGTTGAGAAAAGAGAATGAAGCCCTTCGTAGACATATAGCTGTTCTCCAGGCTGAAGTA
TATGGGGCGAGACTAGCTGCCAAGTACTTGGATAAGGAACTGGCAGGAAGGGTCCAACAG
ATACAATTGCTAGGACGAGATATGAAGGGACCTGCTCATGATAAGCTTTGGAACCAATTA
GAAGCTGAAATACATTTGCATCGTCACAAAACTGTGATCCGAGCCTGCAGAGGACGTAAT
GACTTGAAACGACCAATGCAAGCACCACCAGGCCATGATCAAGATTCCCTAAAGAAAAGC
CAAGGTGTTGGTCCAATTAGAAAAGTTCTCCTCCTTAAGGAAGATCATGAAGGCCTTGGC
ATTTCAATTACAGGTGGGAAAGAACATGGTGTTCCAATCCTCATCTCTGAGATCCATCCG
GGGCAACCTGCTGATAGATGCGGAGGGCTGCACGTTGGGGATGCTATTTTGGCAGTCAAC
GGAGTTAACCTAAGGGACACAAAGCATAAAGAAGCTGTAACTATTCTTTCTCAGCAGAGA
GGAGAGATTGAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAAC
GTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGA
GGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGGA
TTTAATAAGAAGGCAGTAACTGACACACATGAAAATGGAGACCTGGGCACTGCAAGTGAA
ACTCCGCTAGATGACGGTGCTTCAAAATTAGATGATCTGCACACTCTGTATCATAAAAAA
TCTTATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 462 |
| Molecular Weight
| 50519.6 |
| Theoretical pI
| 5.79 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Golgi-associated PDZ and coiled-coil motif-containing protein
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
|
| External Links |
|---|
| GenBank ID Protein
| 9966877 |
| UniProtKB/Swiss-Prot ID
| Q9HD26 |
| UniProtKB/Swiss-Prot Entry Name
| GOPC_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020399.3 |
| GeneCard ID
| GOPC |
| GenAtlas ID
| GOPC |
| HGNC ID
| HGNC:17643 |
| References |
|---|
| General References
| Not Available |