Showing Protein Gamma-aminobutyric acid receptor subunit rho-2 (CDBP03427)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03427
Secondary Accession Numbers Not Available
Name Gamma-aminobutyric acid receptor subunit rho-2
Description Not Available
Synonyms
  1. GABA(A) receptor subunit rho-2
  2. GABA(C) receptor
Gene Name GABRR2
Protein Type Receptor
Biological Properties
General Function Involved in ion transport
Specific Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
postsynaptic membrane
membrane
Function
ligand-gated ion channel activity
extracellular ligand-gated ion channel activity
receptor activity
transmembrane receptor activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
molecular transducer activity
signal transducer activity
gaba receptor activity
gaba-a receptor activity
transporter activity
ion channel activity
Process
establishment of localization
transport
ion transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
  3. Multi-pass membrane protein
  4. Cell junction
  5. synapse
  6. postsynaptic cell membrane
Pathways
Gene Properties
Chromosome Location Chromosome:6
Locus 6q14-q21|6q13-q16.3
SNPs GABRR2
Gene Sequence 
>1473 bp
ATGGTCAAGCCAGGGGGGATTTGCTCTGCCACAGGCTACTGGAAAGCAGCTTTTTGCCTC
ACAGATGTCCACAAAATGCCTTATTTTACAAGACTCATTTTGTTCTTGTTTTGCTTGATG
GTTCTCGTGGAGAGCAGAAAACCCAAGAGGAAGCGATGGACAGGGCAGGTGGAAATGCCC
AAGCCAAGTCACTTATATAAGAAGAACCTTGATGTGACCAAGATCCGGAAGGGAAAGCCT
CAGCAGCTTCTCAGAGTGGACGAGCACGACTTCAGCATGAGACCCGCCTTCGGAGGCCCT
GCCATCCCGGTGGGCGTGGACGTACAGGTGGAGAGCCTGGACAGCATCTCCGAGGTGGAC
ATGGACTTCACTATGACCCTGTACCTGCGGCATTACTGGAAGGATGAGAGGCTAGCTTTC
TCCAGCGCCAGCAACAAGAGCATGACCTTCGATGGCCGGCTGGTGAAGAAGATCTGGGTC
CCTGATGTCTTCTTTGTTCACTCCAAAAGATCGTTCACTCATGACACCACCACTGACAAC
ATCATGCTGAGGGTGTTCCCAGATGGACACGTGCTGTACAGCATGAGGATTACGGTCACT
GCCATGTGCAACATGGACTTCAGCCACTTTCCCCTGGACTCCCAGACCTGTTCTTTGGAG
CTGGAGAGCTATGCCTATACAGATGAAGATCTAATGCTGTACTGGAAGAATGGGGATGAA
TCCCTAAAAACAGATGAGAAGATCTCCTTGTCTCAGTTTCTGATTCAGAAATTTCACACA
ACTTCCAGGCTGGCCTTCTACAGCAGCACTGGCTGGTACAACCGTCTGTACATTAACTTC
ACGTTGCGTCGCCACATCTTCTTCTTCTTGCTCCAAACATATTTCCCTGCCACTCTGATG
GTCATGCTGTCCTGGGTGTCCTTCTGGATCGACCGCAGAGCTGTGCCTGCCAGAGTTTCA
CTGGGTATCACGACGGTGCTGACCATGACCACCATCATCACGGGCGTGAATGCCTCCATG
CCGCGCGTCTCCTACGTCAAGGCCGTGGACATCTACCTCTGGGTCAGCTTTGTGTTCGTG
TTCCTCTCGGTGCTGGAGTATGCGGCTGTCAACTACCTGACCACCGTGCAGGAGCGCAAG
GAACGGAAGCTGCGGGAGAAGTTCCCGTGCATGTGTGGAATGCTTCATTCAAAAACCATG
ATGCTGGATGGAAGCTACAGTGAGTCTGAGGCCAACAGCCTGGCTGGGTACCCCAGAAGC
CATATCCTGACAGAAGAAGAAAGGCAAGACAAAATAGTGGTCCACCTGGGCCTGAGTGGT
GAAGCCAACGCTGCCAGAAAGAAGGGGCTTCTGAAGGGCCAGACGGGTTTTCGTATCTTC
CAGAATACCCATGCCATTGACAAATACTCTAGGTTGATATTCCCTGCCTCCTACATATTT
TTCAACTTAATTTATTGGTCAGTGTTTTCCTAG
Protein Properties
Number of Residues 490
Molecular Weight 56816.6
Theoretical pI 9.56
Pfam Domain Function
Signals
  • ["1-45"]
Transmembrane Regions
  • ["286-306", "319-339", "351-371", "469-489"]
Protein Sequence 
>Gamma-aminobutyric acid receptor subunit rho-2
MVKPGGICSATGYWKAAFCLTDVHKMPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMP
KPSHLYKKNLDVTKIRKGKPQQLLRVDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVD
MDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDN
IMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDE
SLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLM
VMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFV
FLSVLEYAAVNYLTTVQERKERKLREKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRS
HILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIF
FNLIYWSVFS
GenBank ID Protein 168984218
UniProtKB/Swiss-Prot ID P28476
UniProtKB/Swiss-Prot Entry Name GBRR2_HUMAN
PDB IDs Not Available
GenBank Gene ID AL121833
GeneCard ID GABRR2
GenAtlas ID GABRR2
HGNC ID HGNC:4091
References
General References Not Available